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<iframe width="100%" height="450" src="https://www.youtube.com/embed/nA3yXuSqypc" title="OpenScope Predictive Processing Weekly Meeting" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen></iframe>
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## Meeting Notes
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**Progress on Data Release Paper and Review:** Jerome provided an update on the data release paper, including the return of the review from Physiological Review, upcoming meetings with co-authors, and plans to integrate reviewer feedback, with contributions from Christof and Carter regarding new datasets and data uploads.
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Review Feedback and Upcoming Meetings: Jerome announced that the review piece for the data release paper has returned from Physiological Review, and a meeting with all current co-authors is scheduled for June 22nd to discuss the feedback and next steps.
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Integration of Reviewer Suggestions: Jerome noted that reviewers suggested shortening the experimental proposal, and some content from the review may be incorporated into the data release paper, pending further discussion.
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New Dataset Presentation: Jerome mentioned that Christof will present a potential EEG dataset in humans, which is planned for collection and will be discussed in future meetings.
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Data Upload Status: Jerome and Carter discussed the ongoing upload of the latest SLAP2 data, with Carter working on packaging scripts and awaiting infrastructural fixes before final validation and release.
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**Receptive Field Analysis Using Zebra Stimulus:** Marcel presented a detailed update on the analysis pipeline for receptive fields using the zebra stimulus, explaining the methodology, optimization steps, and comparison with Gabor patches, with active discussion and questions from Jerome, Lucas, Severine, Farzaneh, and Alexander.
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Analysis Pipeline Overview: Marcel described the pipeline for analyzing receptive fields, which involves breaking down the zebra stimulus into a library of Gabor wavelets with varying positions, orientations, sizes, and frequencies, and computing correlations between stimulus activation maps and neuronal firing rates.
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Optimization of Filters and Time Windows: Marcel explained the process of optimizing not only the filters (including phase and frequency) but also the time window for correlation, considering both duration and delay to capture neuronal response dynamics.
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Results Across Probes and Areas: Marcel showed results for different probes targeting visual areas, highlighting differences in receptive field sizes and delays, and discussed the impact of histology and area targeting, with input from Severine regarding CCF annotation and area identification.
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Comparison Between Zebra and Gabor Stimuli: Marcel compared receptive field results obtained from zebra and Gabor stimuli, demonstrating both overlap and differences in neuronal responses, and discussed the advantages of the zebra stimulus in terms of diversity and information extraction.
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Discussion on Data Selection and Thresholding: Marcel and Farzaneh discussed session selection criteria, the impact of untuned neurons on measurements, and the importance of applying correlation thresholds to ensure meaningful averaging and interpretation of receptive field data.
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**Figure Planning and Manuscript Strategy:** Jerome, Lucas, Marcel, and Alexander discussed strategies for figure selection and manuscript scope, focusing on presenting reliable responses to both zebra and Gabor stimuli, population versus example data, and the potential for supplemental materials and analysis scripts.
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Scope of Receptive Field Figures: The group debated whether to include only V1 data for clarity and to avoid clutter, with Jerome suggesting a V1-focused figure and supplemental material for broader neuropixels data, and Alexander recommending showing both zebra and Gabor results.
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Population Versus Example Data: Lucas and Alexander discussed the value of presenting both averaged population data and example units, considering correlation thresholds and session selection to highlight differences and richness in receptive field responses.
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Supplemental Materials and Analysis Scripts: Marcel proposed providing analysis scripts and notebooks for specific interests as supplemental material, while Jerome emphasized the importance of concise figures in the main paper to engage readers.
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**Technical and Data Curation Updates:** Carter, Jerome, and Karim discussed the status of SLAP2 data uploads, infrastructural challenges, and the availability of sensory motor session data, with Alexander providing insights on sensory motor conditions and two-photon imaging.
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SLAP2 Data Upload Status: Carter reported that the NWB packaging script for SLAP2 is complete but pending infrastructural fixes at Code Ocean before testing and validation can proceed.
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Sensory Motor Session Data Availability: Karim inquired about the curation and availability of sensory motor condition datasets, with Jerome confirming that boost and sensory motor sessions are uploaded and Alexander noting interesting responses in two-photon and neuropixels data.
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**Upcoming Presentations and SNR Figure Planning:** Jerome and Farzaneh coordinated upcoming presentations, including EEG in humans and SNR analysis, with Davis confirming availability and Farzaneh clarifying the requirements for SNR figures and data formats.
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EEG and SNR Presentation Scheduling: Jerome scheduled a presentation on EEG in humans for next week and confirmed with Farzaneh and Davis that SNR analysis will be ready in two weeks, focusing on individual traces and distributions.
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Clarification of SNR Figure Requirements: Farzaneh clarified that the SNR figure should include individual examples and distributions to highlight signal quality across modalities, with Jerome confirming the approach.
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