grok proteome-interactome

Author: MarkBruns

book/chapter_6.html

@@ -2017,7 +2017,8 @@ <h3 id="day-84---august-23-2025--nutrition-theological-exploration-of-eating-and
 <li>Synthesize all findings to construct a comprehensive response that first affirms and elaborates on the sacredness of daily life, fasting, and stewardship, then directly addresses the biblical arguments for the Eucharistic ritual and communal gathering, and finally integrates insights from other traditions to provide a rich, multi-faceted exploration of the topic.</li>
 </ul>
 <h3 id="day-85---august-24-2025--intellectual-wellbeing-learning-from-challenges"><a class="header" href="#day-85---august-24-2025--intellectual-wellbeing-learning-from-challenges"><a href="https://docs.google.com/document/d/1aJyc8siQRGIw2u_gg4MBJjIelMqIzAvtb5IXUTmJ0yM/edit?usp=sharing">Day 85 - August 24, 2025</a> | <a href="https://g.co/gemini/share/431a89bc801b">Intellectual Wellbeing: Learning from Challenges</a></a></h3>
-<p>Ever since I started working more seriously on investigating the process of <a href="https://markbruns.github.io/PKE/2.Areas/FoundationModelTopics.html#table-2-curated-portfolio-of-100-foundational-model-concepts">developing new foundation models</a> ... including things like measurement systems engineering for new sensor/instrumentation, I have realized that I probably need to spend <em><strong>even more time</strong></em> <strong>Relevant Pondering</strong> ... in reflecting MORE deeply, more exactly, more precisely challenges faced ... that means pushing in to things that have become almost painfully frustrating to contemplate, because contemplation of those things feels like DEFEAT, but <em>greater pain</em> is going to characterize is most RELEVANT.</p>
+<p>Ever since I started working more seriously on investigating the process of <a href="https://markbruns.github.io/PKE/2.Areas/FoundationModelTopics.html#table-2-curated-portfolio-of-100-foundational-model-concepts">developing new foundation models</a>, such as <a href="https://grok.com/share/c2hhcmQtMg%3D%3D_49f5c6d8-a49f-4ed8-92b7-9395d24395b4">a foundational Proteome-Interactome model</a> ... including necessary processes to improve/assure the quality of training data like measurement systems engineering for new sensor/instrumentation, I have realized that I probably need to spend <em><strong>even more time</strong></em> <strong>Relevant Pondering</strong> ... in reflecting MORE deeply, more exactly, more precisely ON the challenges faced, especially on those <em>uncomfortable unknown</em> areas <em>which NOBODY has a good answer for</em> [because <strong>every</strong>body's still guessing, but doesn't want to talk about or publicize that they don't know yet...].</p>
+<p>Relevant Pondering means pushing in to things that have become almost painfully frustrating to contemplate, because contemplation of those things feels like DEFEAT, but <em>greater pain</em> is going to characterize is most RELEVANT.</p>
 <p><strong>Relevant Pondering</strong> is about reflecting upon things that are not easy, usually even painful, but aren't going away ... thus really matter ... returning to PONDER ideas or problems that one thought were important, but at some point seemed to be <em>impenetrable</em> ... these are the puzzles that one just can't quite put together -- so the problem or test remains unsolveda nd unresolved, thus worthy of more pondering -- but only because the point of it is actually RELEVANT and potentially very consequential, because these <em>favorite</em> problems started off being in the category of something that was at first interesting and one could see that the payoff made the problem PROBABLY worthy of pondering, and then, upon further investigation PROVED to be worthy of effort ... EXCEPT that it was HARD ... and thus the kind of thing that someone had not already resolved.</p>
 <p>Toward this end, Gemini was prompted to:</p>
 <ul>

book/print.html

@@ -21414,7 +21414,8 @@ <h3 id="day-84---august-23-2025--nutrition-theological-exploration-of-eating-and
 <li>Synthesize all findings to construct a comprehensive response that first affirms and elaborates on the sacredness of daily life, fasting, and stewardship, then directly addresses the biblical arguments for the Eucharistic ritual and communal gathering, and finally integrates insights from other traditions to provide a rich, multi-faceted exploration of the topic.</li>
 </ul>
 <h3 id="day-85---august-24-2025--intellectual-wellbeing-learning-from-challenges"><a class="header" href="#day-85---august-24-2025--intellectual-wellbeing-learning-from-challenges"><a href="https://docs.google.com/document/d/1aJyc8siQRGIw2u_gg4MBJjIelMqIzAvtb5IXUTmJ0yM/edit?usp=sharing">Day 85 - August 24, 2025</a> | <a href="https://g.co/gemini/share/431a89bc801b">Intellectual Wellbeing: Learning from Challenges</a></a></h3>
-<p>Ever since I started working more seriously on investigating the process of <a href="https://markbruns.github.io/PKE/2.Areas/FoundationModelTopics.html#table-2-curated-portfolio-of-100-foundational-model-concepts">developing new foundation models</a> ... including things like measurement systems engineering for new sensor/instrumentation, I have realized that I probably need to spend <em><strong>even more time</strong></em> <strong>Relevant Pondering</strong> ... in reflecting MORE deeply, more exactly, more precisely challenges faced ... that means pushing in to things that have become almost painfully frustrating to contemplate, because contemplation of those things feels like DEFEAT, but <em>greater pain</em> is going to characterize is most RELEVANT.</p>
+<p>Ever since I started working more seriously on investigating the process of <a href="https://markbruns.github.io/PKE/2.Areas/FoundationModelTopics.html#table-2-curated-portfolio-of-100-foundational-model-concepts">developing new foundation models</a>, such as <a href="https://grok.com/share/c2hhcmQtMg%3D%3D_49f5c6d8-a49f-4ed8-92b7-9395d24395b4">a foundational Proteome-Interactome model</a> ... including necessary processes to improve/assure the quality of training data like measurement systems engineering for new sensor/instrumentation, I have realized that I probably need to spend <em><strong>even more time</strong></em> <strong>Relevant Pondering</strong> ... in reflecting MORE deeply, more exactly, more precisely ON the challenges faced, especially on those <em>uncomfortable unknown</em> areas <em>which NOBODY has a good answer for</em> [because <strong>every</strong>body's still guessing, but doesn't want to talk about or publicize that they don't know yet...].</p>
+<p>Relevant Pondering means pushing in to things that have become almost painfully frustrating to contemplate, because contemplation of those things feels like DEFEAT, but <em>greater pain</em> is going to characterize is most RELEVANT.</p>
 <p><strong>Relevant Pondering</strong> is about reflecting upon things that are not easy, usually even painful, but aren't going away ... thus really matter ... returning to PONDER ideas or problems that one thought were important, but at some point seemed to be <em>impenetrable</em> ... these are the puzzles that one just can't quite put together -- so the problem or test remains unsolveda nd unresolved, thus worthy of more pondering -- but only because the point of it is actually RELEVANT and potentially very consequential, because these <em>favorite</em> problems started off being in the category of something that was at first interesting and one could see that the payoff made the problem PROBABLY worthy of pondering, and then, upon further investigation PROVED to be worthy of effort ... EXCEPT that it was HARD ... and thus the kind of thing that someone had not already resolved.</p>
 <p>Toward this end, Gemini was prompted to:</p>
 <ul>

book/searchindex.js

@@ -1920,7 +1920,9 @@ Today's topic is about getting more out of eating than just swallowing food ...
 
 ### [Day 85 - August 24, 2025](https://docs.google.com/document/d/1aJyc8siQRGIw2u_gg4MBJjIelMqIzAvtb5IXUTmJ0yM/edit?usp=sharing) | [Intellectual Wellbeing: Learning from Challenges](https://g.co/gemini/share/431a89bc801b)
 
-Ever since I started working more seriously on investigating the process of [developing new foundation models](https://markbruns.github.io/PKE/2.Areas/FoundationModelTopics.html#table-2-curated-portfolio-of-100-foundational-model-concepts) ... including things like measurement systems engineering for new sensor/instrumentation, I have realized that I probably need to spend ***even more time*** **Relevant Pondering** ... in reflecting MORE deeply, more exactly, more precisely challenges faced ... that means pushing in to things that have become almost painfully frustrating to contemplate, because contemplation of those things feels like DEFEAT, but *greater pain* is going to characterize is most RELEVANT.  
+Ever since I started working more seriously on investigating the process of [developing new foundation models](https://markbruns.github.io/PKE/2.Areas/FoundationModelTopics.html#table-2-curated-portfolio-of-100-foundational-model-concepts), such as [a foundational Proteome-Interactome model](https://grok.com/share/c2hhcmQtMg%3D%3D_49f5c6d8-a49f-4ed8-92b7-9395d24395b4) ... including necessary processes to improve/assure the quality of training data like measurement systems engineering for new sensor/instrumentation, I have realized that I probably need to spend ***even more time*** **Relevant Pondering** ... in reflecting MORE deeply, more exactly, more precisely ON the challenges faced, especially on those *uncomfortable unknown* areas *which NOBODY has a good answer for* [because **every**body's still guessing, but doesn't want to talk about or publicize that they don't know yet...].
+
+Relevant Pondering means pushing in to things that have become almost painfully frustrating to contemplate, because contemplation of those things feels like DEFEAT, but *greater pain* is going to characterize is most RELEVANT.  
 
 **Relevant Pondering** is about reflecting upon things that are not easy, usually even painful, but aren't going away ... thus really matter ... returning to PONDER ideas or problems that one thought were important, but at some point seemed to be *impenetrable* ... these are the puzzles that one just can't quite put together -- so the problem or test remains unsolveda nd unresolved, thus worthy of more pondering -- but only because the point of it is actually RELEVANT and potentially very consequential, because these *favorite* problems started off being in the category of something that was at first interesting and one could see that the payoff made the problem PROBABLY worthy of pondering, and then, upon further investigation PROVED to be worthy of effort ... EXCEPT that it was HARD ... and thus the kind of thing that someone had not already resolved.