Skip to content

Commit ef28a76

Browse files
authored
Update joss/paper.md
changed the dash to commas for more grammar appropriate use
1 parent 59098e5 commit ef28a76

1 file changed

Lines changed: 1 addition & 1 deletion

File tree

joss/paper.md

Lines changed: 1 addition & 1 deletion
Original file line numberDiff line numberDiff line change
@@ -58,7 +58,7 @@ bibliography: paper.bib
5858

5959
# Summary
6060

61-
Identifying genomes in metagenomics samples can be complicated by taxonomic profiling tools that lack uncertainty quantification and rely on incomplete reference databases. YACHT (**Y**es/No **A**nswers to **C**ommunity membership via **H**ypothesis **T**esting) introduces a $k$-mer sketching based statistical framework that incorporates average nucleotide identity (ANI) and coverage—the portion of k-mers observed for a microbe’s genome detected in a sample—to detect genetic similarity between reference and sample genomes using binomial hypothesis testing on exclusive $k$-mers to confidently determine genome presence/absence [@koslicki2024yacht]. This paper describes the software implementation of this methodology as a command-line tool that detects low-abundant species while controlling the false-negative rate, making it applicable to functional profiling, metatranscriptomics, and clinical microbiome analysis despite incomplete genomes and variable coverage. YACHT is developed with C++ and Python and depends on `sourmash` [@irber2024sourmash] for $k$-mer extraction and management.
61+
Identifying genomes in metagenomics samples can be complicated by taxonomic profiling tools that lack uncertainty quantification and rely on incomplete reference databases. YACHT (**Y**es/No **A**nswers to **C**ommunity membership via **H**ypothesis **T**esting) introduces a $k$-mer sketching based statistical framework that incorporates average nucleotide identity (ANI) and coverage, the portion of k-mers observed for a microbe’s genome detected in a sample, to detect genetic similarity between reference and sample genomes using binomial hypothesis testing on exclusive $k$-mers to confidently determine genome presence/absence [@koslicki2024yacht]. This paper describes the software implementation of this methodology as a command-line tool that detects low-abundant species while controlling the false-negative rate, making it applicable to functional profiling, metatranscriptomics, and clinical microbiome analysis despite incomplete genomes and variable coverage. YACHT is developed with C++ and Python and depends on `sourmash` [@irber2024sourmash] for $k$-mer extraction and management.
6262

6363
# Statement of need
6464

0 commit comments

Comments
 (0)