diff --git a/sdks/typescript/client/src/components/AppFrame.tsx b/sdks/typescript/client/src/components/AppFrame.tsx
index 2b02183e..aa570b4c 100644
--- a/sdks/typescript/client/src/components/AppFrame.tsx
+++ b/sdks/typescript/client/src/components/AppFrame.tsx
@@ -10,7 +10,7 @@ import {
   type McpUiAppCapabilities,
 } from '@modelcontextprotocol/ext-apps/app-bridge';
 
-import { setupSandboxProxyIframe } from '../utils/app-host-utils';
+import { setupSandboxProxyIframe, type SandboxCancelRef } from '../utils/app-host-utils';
 
 /**
  * Build sandbox URL with CSP query parameter for HTTP header-based CSP enforcement.
@@ -165,6 +165,11 @@ export const AppFrame = (props: AppFrameProps) => {
     setError(null);
 
     let mounted = true;
+    // cancelRef is populated synchronously inside setupSandboxProxyIframe's Promise
+    // constructor, before any async yield. This guarantees it is set by the time
+    // React Strict Mode fires the effect cleanup — allowing the orphaned timeout
+    // to be cleared even when cleanup runs before the awaited result resolves.
+    const cancelRef: SandboxCancelRef = {};
 
     const setup = async () => {
       try {
@@ -176,7 +181,7 @@ export const AppFrame = (props: AppFrameProps) => {
           currentAppBridgeRef.current = null;
         }
 
-        const { iframe, onReady } = await setupSandboxProxyIframe(sandboxUrl);
+        const { iframe, onReady } = await setupSandboxProxyIframe(sandboxUrl, cancelRef);
 
         if (!mounted) return;
 
@@ -237,6 +242,7 @@ export const AppFrame = (props: AppFrameProps) => {
 
     return () => {
       mounted = false;
+      cancelRef.cancel?.();
     };
   }, [sandbox.url, sandbox.csp, appBridge]);
 
diff --git a/sdks/typescript/client/src/components/__tests__/AppFrame.test.tsx b/sdks/typescript/client/src/components/__tests__/AppFrame.test.tsx
index a2bc1837..d1f508cf 100644
--- a/sdks/typescript/client/src/components/__tests__/AppFrame.test.tsx
+++ b/sdks/typescript/client/src/components/__tests__/AppFrame.test.tsx
@@ -119,7 +119,10 @@ describe('<AppFrame />', () => {
     render(<AppFrame {...getPropsWithBridge()} />);
 
     await waitFor(() => {
-      expect(appHostUtils.setupSandboxProxyIframe).toHaveBeenCalledWith(defaultProps.sandbox.url);
+      expect(appHostUtils.setupSandboxProxyIframe).toHaveBeenCalledWith(
+        defaultProps.sandbox.url,
+        expect.any(Object),
+      );
     });
   });
 
@@ -279,6 +282,39 @@ describe('<AppFrame />', () => {
   });
 
   describe('lifecycle', () => {
+    it('should cancel sandbox timeout when effect cleanup fires before await resolves (StrictMode)', async () => {
+      // Simulate the cancelRef being populated synchronously (as the real impl does).
+      // Capture the cancelRef passed to setupSandboxProxyIframe and verify cancel() is
+      // called before the mock ever resolves — this is the Strict Mode timing scenario.
+      let capturedCancelRef: { cancel?: () => void } | undefined;
+      const cancelSpy = vi.fn();
+
+      vi.mocked(appHostUtils.setupSandboxProxyIframe).mockImplementation(
+        async (_url, cancelRef) => {
+          capturedCancelRef = cancelRef;
+          // Synchronously populate the cancelRef, mirroring the real implementation
+          if (cancelRef) {
+            cancelRef.cancel = cancelSpy;
+          }
+          // Return a promise that never resolves, simulating a slow sandbox
+          return new Promise(() => {});
+        },
+      );
+
+      const { unmount } = render(<AppFrame {...getPropsWithBridge()} />);
+
+      // Flush microtasks so the mock implementation runs
+      await act(async () => {});
+
+      expect(capturedCancelRef).toBeDefined();
+
+      // Unmount (simulates Strict Mode cleanup between effect invocations)
+      unmount();
+
+      // cancel() must have been called to clear the orphaned timeout
+      expect(cancelSpy).toHaveBeenCalledTimes(1);
+    });
+
     it('should preserve iframe across re-renders', async () => {
       const { rerender } = render(<AppFrame {...getPropsWithBridge()} />);
 
@@ -329,7 +365,10 @@ describe('<AppFrame />', () => {
       // Should call setupSandboxProxyIframe again with new URL
       await waitFor(() => {
         expect(appHostUtils.setupSandboxProxyIframe).toHaveBeenCalledTimes(2);
-        expect(appHostUtils.setupSandboxProxyIframe).toHaveBeenLastCalledWith(newSandboxUrl);
+        expect(appHostUtils.setupSandboxProxyIframe).toHaveBeenLastCalledWith(
+          newSandboxUrl,
+          expect.any(Object),
+        );
       });
     });
 
diff --git a/sdks/typescript/client/src/utils/app-host-utils.test.ts b/sdks/typescript/client/src/utils/app-host-utils.test.ts
new file mode 100644
index 00000000..b67ddafe
--- /dev/null
+++ b/sdks/typescript/client/src/utils/app-host-utils.test.ts
@@ -0,0 +1,65 @@
+import { describe, it, expect, vi, beforeEach, afterEach } from 'vitest';
+
+import { SANDBOX_PROXY_READY_METHOD } from '@modelcontextprotocol/ext-apps/app-bridge';
+
+import { setupSandboxProxyIframe, type SandboxCancelRef } from './app-host-utils';
+
+describe('setupSandboxProxyIframe', () => {
+  beforeEach(() => {
+    vi.useFakeTimers();
+  });
+
+  afterEach(() => {
+    vi.useRealTimers();
+  });
+
+  it('rejects onReady when sandbox never becomes ready (timeout)', async () => {
+    const cancelRef: SandboxCancelRef = {};
+    const { onReady } = await setupSandboxProxyIframe(
+      new URL('https://example.com/proxy'),
+      cancelRef,
+    );
+
+    const assertion = expect(onReady).rejects.toThrow(
+      /Timed out waiting for sandbox proxy iframe to be ready/,
+    );
+    await vi.advanceTimersByTimeAsync(10_000);
+    await assertion;
+  });
+
+  it('resolves onReady when cancel is called before the sandbox handshake completes', async () => {
+    const cancelRef: SandboxCancelRef = {};
+    const { onReady } = await setupSandboxProxyIframe(
+      new URL('https://example.com/proxy'),
+      cancelRef,
+    );
+
+    expect(cancelRef.cancel).toBeTypeOf('function');
+    cancelRef.cancel!();
+
+    await expect(onReady).resolves.toBeUndefined();
+
+    await vi.advanceTimersByTimeAsync(10_000);
+  });
+
+  it('resolves onReady when the sandbox posts the ready message', async () => {
+    const { iframe, onReady } = await setupSandboxProxyIframe(new URL('https://example.com/proxy'));
+
+    // jsdom does not attach contentWindow to programmatic iframes; the handler matches
+    // event.source === iframe.contentWindow, so expose a stable mock window reference.
+    const sandboxWindow = {} as Window;
+    Object.defineProperty(iframe, 'contentWindow', {
+      get: () => sandboxWindow,
+      configurable: true,
+    });
+
+    window.dispatchEvent(
+      new MessageEvent('message', {
+        source: sandboxWindow,
+        data: { method: SANDBOX_PROXY_READY_METHOD },
+      }),
+    );
+
+    await expect(onReady).resolves.toBeUndefined();
+  });
+});
diff --git a/sdks/typescript/client/src/utils/app-host-utils.ts b/sdks/typescript/client/src/utils/app-host-utils.ts
index 764de1aa..3110ada0 100644
--- a/sdks/typescript/client/src/utils/app-host-utils.ts
+++ b/sdks/typescript/client/src/utils/app-host-utils.ts
@@ -7,7 +7,19 @@ import { type Client } from '@modelcontextprotocol/sdk/client/index.js';
 import { type Tool } from '@modelcontextprotocol/sdk/types.js';
 const DEFAULT_SANDBOX_TIMEOUT_MS = 10000;
 
-export async function setupSandboxProxyIframe(sandboxProxyUrl: URL): Promise<{
+/**
+ * Assigned synchronously inside the onReady executor so callers can invoke
+ * `cancel()` while still awaiting `setupSandboxProxyIframe` or `onReady`.
+ * Cancelling clears timers and listeners and resolves `onReady`.
+ */
+export interface SandboxCancelRef {
+  cancel?: () => void;
+}
+
+export async function setupSandboxProxyIframe(
+  sandboxProxyUrl: URL,
+  cancelRef?: SandboxCancelRef,
+): Promise<{
   iframe: HTMLIFrameElement;
   onReady: Promise<void>;
 }> {
@@ -34,6 +46,17 @@ export async function setupSandboxProxyIframe(sandboxProxyUrl: URL): Promise<{
       }
     }, DEFAULT_SANDBOX_TIMEOUT_MS);
 
+    if (cancelRef) {
+      cancelRef.cancel = () => {
+        if (!settled) {
+          settled = true;
+          clearTimeout(timeoutId);
+          cleanup();
+          resolve();
+        }
+      };
+    }
+
     const messageListener = (event: MessageEvent) => {
       if (event.source === iframe.contentWindow) {
         if (event.data && event.data.method === SANDBOX_PROXY_READY_METHOD) {