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CT images registration to MRI (be it T1w or T2w) can be somehow tricky.
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Here a few tricks:
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Reorientation can help
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The -orient LPS corresponds to the direction where the increasing numbers are pointing at (typically RAS in radiological convention) and take the opposite directions (special AFNI...).
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If you want to exchange to axis, change "target" letters accordingly
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RPI -> RIP
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If you want to revert one dimension, be careful to modify another axis:
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RPI -> RPS becomes LPS to exchange I by S, and good R-L dimension as well
Most of the images in our center are acquired in the right direction, but with an encoding matching inverse Left-Right Encoding to the one that is coming out of the MRI
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