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Feature groupwise normalization#217

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lucas-diedrich wants to merge 4 commits into
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feature/groupwise-normalization-1
Open

Feature groupwise normalization#217
lucas-diedrich wants to merge 4 commits into
mainfrom
feature/groupwise-normalization-1

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Batches with very different summed intensities/missingness patterns might need to be normalized separately (e.g. in this DDA/TMT experiment)

Function; Analysis script

This PR adds the option to normalize separately per batch. Default behavior remains unchanged.

Claude: Implement the group_column logic in @src/alphapepttools/pp/norm.py. The logic should follow the logic in the @src/alphapepttools/pp/impute.py module.
  ⎿  Read src/alphapepttools/pp/norm.py (223 lines)
  ⎿  Read src/alphapepttools/pp/impute.py (572 lines)
@lucas-diedrich lucas-diedrich self-assigned this May 7, 2026
@lucas-diedrich lucas-diedrich added the enhancement New feature or request label May 7, 2026
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