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Review TMT tutorial notebook#227

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vbrennsteiner wants to merge 21 commits into
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Review TMT tutorial notebook#227
vbrennsteiner wants to merge 21 commits into
docs/tmt-datafrom
docs/tmt-data_review

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@vbrennsteiner

@vbrennsteiner vbrennsteiner commented Jun 3, 2026

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NOTE: in order to run grouped normalization, PR #217 was merged into this branch. Consequently, 217 should be merged into main before tmt-data.

NOTE: The change of bar/box/violin plot axis indices to 0-indexing was already merged to main and this PR, hence the diff in plots.py

NOTE: Ye olde Pandas warning for groupby without explicit observed=False appeared for CV calculation and grouped CVs, fixed it in the respective metrics by adding observed=False

Purpose of this PR

  • Set all figures to harmonized alphapepttools plots
  • Minor changes in introduction
  • Numerically equivalent silhouette score implementation via sklearn to avoid in-line scib-metrics dependency

lucas-diedrich and others added 21 commits May 7, 2026 17:04
Claude: Implement the group_column logic in @src/alphapepttools/pp/norm.py. The logic should follow the logic in the @src/alphapepttools/pp/impute.py module.
  ⎿  Read src/alphapepttools/pp/norm.py (223 lines)
  ⎿  Read src/alphapepttools/pp/impute.py (572 lines)
@vbrennsteiner vbrennsteiner self-assigned this Jun 3, 2026
@vbrennsteiner vbrennsteiner added documentation Improvements or additions to documentation enhancement New feature or request dependencies labels Jun 3, 2026
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