diff --git a/pixi.toml b/pixi.toml
index 4a84418b..fbb98bb3 100644
--- a/pixi.toml
+++ b/pixi.toml
@@ -13,7 +13,7 @@ loguru = "*"
 lomap2 = "*"
 networkx = "*"
 nglview = "*"
-openff-interchange-base = "*"
+openff-interchange-base = ">=0.5.0"
 openff-toolkit-base = "*"
 parmed = "*"
 pyarrow = "*"
diff --git a/recipes/biosimspace/recipe.yaml b/recipes/biosimspace/recipe.yaml
index 11ae465d..95ea83ca 100644
--- a/recipes/biosimspace/recipe.yaml
+++ b/recipes/biosimspace/recipe.yaml
@@ -27,7 +27,14 @@ requirements:
     - lomap2
     - networkx
     - nglview
-    - openff-interchange-base
+    - if: match(python, ">=3.11")
+      then:
+        - openff-interchange-base >=0.5.0
+      else:
+        - openff-interchange-base
+    - if: match(python, "<3.11")
+      then:
+        - setuptools <82
     - openff-toolkit-base
     - parmed
     - pyarrow
@@ -61,6 +68,9 @@ tests:
     requirements:
       run:
         - pytest
+        - if: match(python, "<3.11")
+          then:
+            - setuptools <82
         - if: linux and x86_64
           then:
             - ambertools
diff --git a/tests/Align/test_align.py b/tests/Align/test_align.py
index 16592d53..23edc071 100644
--- a/tests/Align/test_align.py
+++ b/tests/Align/test_align.py
@@ -829,6 +829,7 @@ def test_ion_merge(system):
         ),
     ],
 )
+@pytest.mark.skipif(has_openff is False, reason="Requires OpenFF to be installed.")
 def test_ring_opening_and_size_change(ligands, mapping):
     # These perturbations involve ring formation (acyclic atoms in mol0 become
     # ring members in mol1) combined with ring size changes in the existing
@@ -946,14 +947,6 @@ def test_ring_breaking_intrascale():
     assert len(omm_nopatch.changed_exceptions()) == len(ref_exceptions)
 
 
-@pytest.mark.skipif(
-    not has_antechamber or not has_tleap,
-    reason="Requires antechamber and tLEaP to be installed.",
-)
-@pytest.mark.skipif(
-    not has_openff,
-    reason="Requires OpenFF to be installed.",
-)
 def test_ring_breaking_intrascale_m338():
     """
     Test that ring-breaking merges produce correct intrascale matrices for a
@@ -1008,12 +1001,8 @@ def test_ring_breaking_intrascale_m338():
         38: 36,
     }
 
-    mol0 = BSS.Parameters.openff_unconstrained_2_2_1(
-        BSS.IO.readMolecules(f"{url}/int1.sdf")[0]
-    ).getMolecule()
-    mol1 = BSS.Parameters.openff_unconstrained_2_2_1(
-        BSS.IO.readMolecules(f"{url}/m338.sdf")[0]
-    ).getMolecule()
+    mol0 = BSS.IO.readMolecules([f"{url}/int1.prm7", f"{url}/int1.rst7"])[0]
+    mol1 = BSS.IO.readMolecules([f"{url}/m338.prm7", f"{url}/m338.rst7"])[0]
 
     mol0_aligned = BSS.Align.rmsdAlign(mol0, mol1, mapping)
     merged = BSS.Align.merge(
@@ -1210,7 +1199,10 @@ def test_ring_breaking_cross_bond_cleanup():
         for p in sire_mol.property(f"dihedral{suffix}").potentials():
             j = mol_info.atom_idx(p.atom1()).value()
             k = mol_info.atom_idx(p.atom2()).value()
-            assert (min(j, k), max(j, k)) not in changing, (
+            assert (
+                min(j, k),
+                max(j, k),
+            ) not in changing, (
                 f"dihedral{suffix} central bond ({j},{k}) spans absent bond"
             )