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Expand file tree Collapse file tree Original file line number Diff line number Diff line change @@ -100,6 +100,21 @@ by editing [targets.yaml](/config/targets.yaml) or via the command line:
100100snakemake --config CONTEXT_FASTA="path/to/fasta"
101101` ` `
102102
103+ > [!IMPORTANT]
104+ > The GISAID EpiCoV database is proprietary and not openly accessible. For details, refer
105+ > to the [GISAID Terms of Use](https://gisaid.org/terms-of-use/).
106+ > VIPERA uses [GISAIDR](https://github.com/Wytamma/GISAIDR) to automate access to GISAID data.
107+ > However, this access can be unstable or occasionally fail due to changes in the platform.
108+ > Possible workarounds are documented in the GISAIDR repository (e.g. issues
109+ > [#55](https://github.com/Wytamma/GISAIDR/issues/55) and [#58](https://github.com/Wytamma/GISAIDR/issues/58)).
110+ > If programmatic access fails, a suitable context dataset must be manually provided by setting the
111+ > `CONTEXT_FASTA` parameter to the path of a FASTA file.
112+ > As a last resort, some of the analyses can be allowed to run even if context-dependent rules
113+ > fail by passing the `--keep-going` flag to Snakemake.
114+ > To replicate [our work](https://doi.org/10.1093/ve/veae018), the automatic context dataset is available via
115+ > DOI: [10.55876/gis8.250718er](https://doi.org/10.55876/gis8.250718er) (EPI_SET_250718er).
116+ > Read more about EPI_SETs [here](https://gisaid.org/episet/).
117+
103118# # Mapping reference sequence
104119
105120Setting `MAPPING_REFERENCES_FASTA` to `null` (default) will enable the automatic download of the
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