diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 2c29581d2b1..4d80337c5ce 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -577,37 +577,11 @@ jobs:
       - uses: dtolnay/rust-toolchain@stable
         with:
           components: rust-src
-      - name: Install python3 standalone debug build with nox
-        run: |
-          PBS_RELEASE="20241219"
-          PBS_PYTHON_VERSION="3.13.1"
-          PBS_ARCHIVE="cpython-${PBS_PYTHON_VERSION}+${PBS_RELEASE}-x86_64-unknown-linux-gnu-debug-full.tar.zst"
-          wget "https://github.com/indygreg/python-build-standalone/releases/download/${PBS_RELEASE}/${PBS_ARCHIVE}"
-          tar -I zstd -xf "${PBS_ARCHIVE}"
-          ls -l $(pwd)/python/install/bin
-          ls -l $(pwd)/python/install/lib
-          echo PATH=$(pwd)/python/install/bin:$PATH >> $GITHUB_ENV
-          echo LD_LIBRARY_PATH=$(pwd)/python/install/lib:$LD_LIBRARY_PATH >> $GITHUB_ENV
-          echo PYTHONHOME=$(pwd)/python/install >> $GITHUB_ENV
-          echo PYO3_PYTHON=$(pwd)/python/install/bin/python3 >> $GITHUB_ENV
-      - run: python3 -m sysconfig
-      - run: python3 -m pip install --upgrade pip && pip install nox[uv]
-      - run: |
-          PYO3_CONFIG_FILE=$(mktemp)
-          cat > $PYO3_CONFIG_FILE << EOF
-          implementation=CPython
-          version=3.13
-          shared=true
-          abi3=false
-          lib_name=python3.13d
-          lib_dir=${{ github.workspace }}/python/install/lib
-          executable=${{ github.workspace }}/python/install/bin/python3
-          pointer_width=64
-          build_flags=Py_DEBUG,Py_REF_DEBUG
-          suppress_build_script_link_lines=false
-          EOF
-          echo PYO3_CONFIG_FILE=$PYO3_CONFIG_FILE >> $GITHUB_ENV
-      - run: python3 -m nox -s test
+      - uses: astral-sh/setup-uv@v6
+        with:
+          python-version: "3.13+debug"
+      - run: uvx python -m sysconfig
+      - run: uvx nox -s test
 
   test-version-limits:
     needs: [fmt]
diff --git a/build.rs b/build.rs
index 25e3f54e331..a7dd8f87988 100644
--- a/build.rs
+++ b/build.rs
@@ -2,7 +2,7 @@ use std::env;
 
 use pyo3_build_config::pyo3_build_script_impl::{cargo_env_var, errors::Result};
 use pyo3_build_config::{
-    add_python_framework_link_args, bail, print_feature_cfgs, InterpreterConfig,
+    add_libpython_rpath_link_args, bail, print_feature_cfgs, InterpreterConfig,
 };
 
 fn ensure_auto_initialize_ok(interpreter_config: &InterpreterConfig) -> Result<()> {
@@ -44,7 +44,7 @@ fn configure_pyo3() -> Result<()> {
     print_feature_cfgs();
 
     // Make `cargo test` etc work on macOS with Xcode bundled Python
-    add_python_framework_link_args();
+    add_libpython_rpath_link_args();
 
     Ok(())
 }
diff --git a/pyo3-build-config/src/lib.rs b/pyo3-build-config/src/lib.rs
index 156ecd309f6..91223eb8183 100644
--- a/pyo3-build-config/src/lib.rs
+++ b/pyo3-build-config/src/lib.rs
@@ -23,6 +23,8 @@ pub use impl_::{
     CrossCompileConfig, InterpreterConfig, PythonImplementation, PythonVersion, Triple,
 };
 
+#[cfg(feature = "resolve-config")]
+use target_lexicon::Architecture;
 use target_lexicon::OperatingSystem;
 
 /// Adds all the [`#[cfg]` flags](index.html) to the current compilation.
@@ -92,9 +94,17 @@ fn _add_extension_module_link_args(triple: &Triple, mut writer: impl std::io::Wr
 #[cfg(feature = "resolve-config")]
 pub fn add_libpython_rpath_link_args() {
     let target = impl_::target_triple_from_env();
+    let is_linking_libpython = impl_::is_linking_libpython_for_target(&target);
+    let is_wasm = matches!(
+        target.architecture,
+        Architecture::Wasm32 | Architecture::Wasm64
+    );
+    let is_emscripten = target.operating_system == target_lexicon::OperatingSystem::Emscripten;
     _add_libpython_rpath_link_args(
         get(),
-        impl_::is_linking_libpython_for_target(&target),
+        // webassembly targets generally don't support rpath, emscripten is the only exception currently aware of:
+        // https://github.com/emscripten-core/emscripten/issues/22126
+        is_linking_libpython && (!is_wasm || is_emscripten),
         std::io::stdout(),
     )
 }
@@ -102,10 +112,10 @@ pub fn add_libpython_rpath_link_args() {
 #[cfg(feature = "resolve-config")]
 fn _add_libpython_rpath_link_args(
     interpreter_config: &InterpreterConfig,
-    is_linking_libpython: bool,
+    should_emit_rpath: bool,
     mut writer: impl std::io::Write,
 ) {
-    if is_linking_libpython {
+    if should_emit_rpath {
         if let Some(lib_dir) = interpreter_config.lib_dir.as_ref() {
             writeln!(writer, "cargo:rustc-link-arg=-Wl,-rpath,{lib_dir}").unwrap();
         }