diff --git a/.github/configs/nvidia-master.yaml b/.github/configs/nvidia-master.yaml
index 403cb42b3..e63a79eaf 100644
--- a/.github/configs/nvidia-master.yaml
+++ b/.github/configs/nvidia-master.yaml
@@ -2964,7 +2964,7 @@ dsv4-fp8-h200-sglang-mtp:
   # field, so dp-attn=true is used as the existing vLLM script switch for DP4
   # layouts on 4 allocated GPUs.
 dsv4-fp4-b300-vllm:
-  image: vllm/vllm-openai:v0.20.0-cu130
+  image: vllm/vllm-openai:v0.21.0
   model: deepseek-ai/DeepSeek-V4-Pro
   model-prefix: dsv4
   runner: b300
diff --git a/perf-changelog.yaml b/perf-changelog.yaml
index db3b465b1..e8db0c360 100644
--- a/perf-changelog.yaml
+++ b/perf-changelog.yaml
@@ -2802,3 +2802,9 @@
   description:
     - "Update vLLM image from v0.20.0-cu130 (14d old) to v0.21.0"
   pr-link: https://github.com/SemiAnalysisAI/InferenceX/pull/1457
+
+- config-keys:
+    - dsv4-fp4-b300-vllm
+  description:
+    - "Update vLLM image from v0.20.0-cu130 (18d old) to v0.21.0"
+  pr-link: https://github.com/SemiAnalysisAI/InferenceX/pull/1456