diff --git a/data/testResults/README.md b/data/testResults/README.md
index 1b3495b5..5a9597e0 100644
--- a/data/testResults/README.md
+++ b/data/testResults/README.md
@@ -4,7 +4,7 @@ The file here contains results from the [MACAW](https://github.com/Devlin-Moyer/
 
 The test results shown here were obtained by the GitHub Actions run in:
 
-- **PR #1035** (QC)
+- **PR #1047** (QC)
 - **PR #973** (gene essentiality)
 
 The results will be updated by any subsequent pull request. Summary results are shown as a comment in the corresponding pull request.
diff --git a/data/testResults/macaw_results.csv b/data/testResults/macaw_results.csv
index 5b8d58da..b5d5687b 100644
--- a/data/testResults/macaw_results.csv
+++ b/data/testResults/macaw_results.csv
@@ -12876,3 +12876,5 @@ MAR20188,MAM01098m <=> MAM01098c,MAM01098c;MAM01098m,ok,ok,ok,N/A
 MAR20189,MAM01329c + 2 MAM01824m + 5 MAM02039m --> MAM01328c + 2 MAM01826m + 4 MAM02039i,MAM01328c;MAM01329c,ok,ok,ok,N/A
 MAR20190,MAM01329c + MAM02039c + MAM02553c --> MAM01328c + MAM02552c,MAM01328c;MAM01329c,ok,ok,ok,N/A
 MAR20191,MAM01371m + MAM01974m + MAM02578m --> MAM01285m + MAM01975m + MAM02751m,ok,ok,ok,ok,N/A
+MAR20193,MAM00180c <=> MAM00180e,ok,ok,ok,ok,N/A
+MAR20194,MAM00180e <=> ,ok,ok,ok,ok,N/A
diff --git a/model/Human-GEM.yml b/model/Human-GEM.yml
index 681c03b0..59835f28 100644
--- a/model/Human-GEM.yml
+++ b/model/Human-GEM.yml
@@ -60031,6 +60031,13 @@
       - formula: "C10H16N3O6S2"
       - charge: -1
       - inchis: "InChI=1S/C10H17N3O6S2/c11-5(10(18)19)1-2-7(14)13-6(4-21-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1"
+    - !!omap
+      - id: "MAM00180e"
+      - name: "(S)-dihydroorotate"
+      - compartment: "e"
+      - formula: "C5H5N2O4"
+      - charge: -1
+      - metFrom: "HMRdatabase"
 - reactions:
     - !!omap
       - id: "MAR03905"
@@ -245971,6 +245978,26 @@
       - references: "PMID:11080211;PMID:1356223;PMID:14583610;PMID:16213501;PMID:7595668;PMID:8838581;PMID:9053810"
       - subsystem: "Alanine, aspartate and glutamate metabolism"
       - confidence_score: 0
+    - !!omap
+      - id: "MAR20193"
+      - name: "(S)-dihydroorotate transport, cytosol to extracellular"
+      - metabolites: !!omap
+          - MAM00180c: -1
+          - MAM00180e: 1
+      - lower_bound: -1000
+      - upper_bound: 1000
+      - references: "PMID:30643150"
+      - subsystem: "Transport reactions"
+      - confidence_score: 0
+    - !!omap
+      - id: "MAR20194"
+      - name: "Exchange of (S)-dihydroorotate"
+      - metabolites: !!omap
+          - MAM00180e: -1
+      - lower_bound: -1000
+      - upper_bound: 1000
+      - subsystem: "Exchange/demand reactions"
+      - confidence_score: 0
 - genes:
     - !!omap
       - id: "ENSG00000000419"
diff --git a/model/metabolites.tsv b/model/metabolites.tsv
index 928d9f09..56d65ace 100644
--- a/model/metabolites.tsv
+++ b/model/metabolites.tsv
@@ -8459,3 +8459,4 @@ MAM00077e	MAM00077			HMDB0000795	CHEBI:51340	123929	LMPR0104010022	CE2416			MNXM
 MAM20084m	MAM20084	4fe4s			CHEBI:33722	6398953					MNXM732007		
 MAM20085m	MAM20085	2fe2s			CHEBI:33737	5460691					MNXM1107419		
 MAM20086m	MAM20086		C17267		CHEBI:52857	44176418					MNXM2032		
+MAM00180e	MAM00180	dhor__S	C00337		CHEBI:17025				HC00285	dhor_S	MNXM252		
diff --git a/model/reactions.tsv b/model/reactions.tsv
index e5b1099e..dc345447 100644
--- a/model/reactions.tsv
+++ b/model/reactions.tsv
@@ -12876,3 +12876,5 @@ MAR20188											0
 MAR20189											0			
 MAR20190											0			
 MAR20191	R00253	GLNS	R00253C	r0077		GLNS	MNXR100024	HMR_3890	RCR10506		0		RHEA:16169	HMR_3890
+MAR20193											0			
+MAR20194											0