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feat: add (S)-dihydroorotate transport and exchange reactions #1047

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42999a2
feat: add (S)-dihydroorotate transport and exchange reactions (#357)
edkerk Jul 11, 2026
815120f
chore: add QC test results [skip ci]
edkerk Jul 11, 2026
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2 changes: 1 addition & 1 deletion data/testResults/README.md
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Expand Up @@ -4,7 +4,7 @@ The file here contains results from the [MACAW](https://github.com/Devlin-Moyer/

The test results shown here were obtained by the GitHub Actions run in:

- **PR #1035** (QC)
- **PR #1047** (QC)
- **PR #973** (gene essentiality)

The results will be updated by any subsequent pull request. Summary results are shown as a comment in the corresponding pull request.
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2 changes: 2 additions & 0 deletions data/testResults/macaw_results.csv
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Expand Up @@ -12876,3 +12876,5 @@ MAR20188,MAM01098m <=> MAM01098c,MAM01098c;MAM01098m,ok,ok,ok,N/A
MAR20189,MAM01329c + 2 MAM01824m + 5 MAM02039m --> MAM01328c + 2 MAM01826m + 4 MAM02039i,MAM01328c;MAM01329c,ok,ok,ok,N/A
MAR20190,MAM01329c + MAM02039c + MAM02553c --> MAM01328c + MAM02552c,MAM01328c;MAM01329c,ok,ok,ok,N/A
MAR20191,MAM01371m + MAM01974m + MAM02578m --> MAM01285m + MAM01975m + MAM02751m,ok,ok,ok,ok,N/A
MAR20193,MAM00180c <=> MAM00180e,ok,ok,ok,ok,N/A
MAR20194,MAM00180e <=> ,ok,ok,ok,ok,N/A
27 changes: 27 additions & 0 deletions model/Human-GEM.yml
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Expand Up @@ -60031,6 +60031,13 @@
- formula: "C10H16N3O6S2"
- charge: -1
- inchis: "InChI=1S/C10H17N3O6S2/c11-5(10(18)19)1-2-7(14)13-6(4-21-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1"
- !!omap
- id: "MAM00180e"
- name: "(S)-dihydroorotate"
- compartment: "e"
- formula: "C5H5N2O4"
- charge: -1
- metFrom: "HMRdatabase"
- reactions:
- !!omap
- id: "MAR03905"
Expand Down Expand Up @@ -245971,6 +245978,26 @@
- references: "PMID:11080211;PMID:1356223;PMID:14583610;PMID:16213501;PMID:7595668;PMID:8838581;PMID:9053810"
- subsystem: "Alanine, aspartate and glutamate metabolism"
- confidence_score: 0
- !!omap
- id: "MAR20193"
- name: "(S)-dihydroorotate transport, cytosol to extracellular"
- metabolites: !!omap
- MAM00180c: -1
- MAM00180e: 1
- lower_bound: -1000
- upper_bound: 1000
- references: "PMID:30643150"
- subsystem: "Transport reactions"
- confidence_score: 0
- !!omap
- id: "MAR20194"
- name: "Exchange of (S)-dihydroorotate"
- metabolites: !!omap
- MAM00180e: -1
- lower_bound: -1000
- upper_bound: 1000
- subsystem: "Exchange/demand reactions"
- confidence_score: 0
- genes:
- !!omap
- id: "ENSG00000000419"
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1 change: 1 addition & 0 deletions model/metabolites.tsv
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Expand Up @@ -8459,3 +8459,4 @@ MAM00077e MAM00077 HMDB0000795 CHEBI:51340 123929 LMPR0104010022 CE2416 MNXM
MAM20084m MAM20084 4fe4s CHEBI:33722 6398953 MNXM732007
MAM20085m MAM20085 2fe2s CHEBI:33737 5460691 MNXM1107419
MAM20086m MAM20086 C17267 CHEBI:52857 44176418 MNXM2032
MAM00180e MAM00180 dhor__S C00337 CHEBI:17025 HC00285 dhor_S MNXM252
2 changes: 2 additions & 0 deletions model/reactions.tsv
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Expand Up @@ -12876,3 +12876,5 @@ MAR20188 0
MAR20189 0
MAR20190 0
MAR20191 R00253 GLNS R00253C r0077 GLNS MNXR100024 HMR_3890 RCR10506 0 RHEA:16169 HMR_3890
MAR20193 0
MAR20194 0