diff --git a/.gitignore b/.gitignore
index 2914690d..a57732fa 100644
--- a/.gitignore
+++ b/.gitignore
@@ -11,3 +11,6 @@
 # rspec failure tracking
 .rspec_status
 Gemfile.*.lock
+
+# MacOS
+.DS_Store
diff --git a/lib/openapi_first.rb b/lib/openapi_first.rb
index 161b9f96..b8922e29 100644
--- a/lib/openapi_first.rb
+++ b/lib/openapi_first.rb
@@ -55,8 +55,11 @@ def self.find_error_response(name)
 
   # Load and dereference an OpenAPI spec file or return the Definition if it's already loaded
   # @param filepath_or_definition [String, Definition] The path to the file or a Definition object
+  # @param only [Proc, nil] An optional proc to filter paths. It is called with the path string and should return
+  # true/false
+  # @param path_prefix [String, nil] An optional path prefix, that is not documented, that all requests begin with.
   # @return [Definition]
-  def self.load(filepath_or_definition, only: nil, &)
+  def self.load(filepath_or_definition, only: nil, path_prefix: nil, &)
     return filepath_or_definition if filepath_or_definition.is_a?(Definition)
     return self[filepath_or_definition] if filepath_or_definition.is_a?(Symbol)
 
@@ -64,16 +67,16 @@ def self.load(filepath_or_definition, only: nil, &)
     raise FileNotFoundError, "File not found: #{filepath}" unless File.exist?(filepath)
 
     contents = FileLoader.load(filepath)
-    parse(contents, only:, filepath:, &)
+    parse(contents, only:, filepath:, path_prefix:, &)
   end
 
   # Parse a dereferenced Hash
   # @return [Definition]
   # TODO: This needs to work with unresolved contents as well
-  def self.parse(contents, only: nil, filepath: nil, &)
+  def self.parse(contents, only: nil, filepath: nil, path_prefix: nil, &)
     contents = ::JSON.parse(::JSON.generate(contents)) # Deeply stringify keys, because of YAML. See https://github.com/ahx/openapi_first/issues/367
     contents['paths'].filter!(&->(key, _) { only.call(key) }) if only
-    Definition.new(contents, filepath, &)
+    Definition.new(contents, filepath, path_prefix, &)
   end
 end
 
diff --git a/lib/openapi_first/definition.rb b/lib/openapi_first/definition.rb
index dada7c64..623eab5f 100644
--- a/lib/openapi_first/definition.rb
+++ b/lib/openapi_first/definition.rb
@@ -11,6 +11,8 @@ class Definition
 
     # @return [String,nil]
     attr_reader :filepath
+    # @return [String,nil]
+    attr_reader :path_prefix
     # @return [Configuration]
     attr_reader :config
     # @return [Enumerable[String]]
@@ -20,8 +22,10 @@ class Definition
 
     # @param contents [Hash] The OpenAPI document.
     # @param filepath [String] The file path of the OpenAPI document.
-    def initialize(contents, filepath = nil)
+    # @param path_prefix [String,nil] An optional path prefix, that is not documented, that all requests begin with.
+    def initialize(contents, filepath = nil, path_prefix = nil)
       @filepath = filepath
+      @path_prefix = path_prefix
       @config = OpenapiFirst.configuration.child
       yield @config if block_given?
       @config.freeze
@@ -79,23 +83,22 @@ def validate_request(request, raise_error: false)
     end
 
     # Validates the response against the API description.
-    # @param rack_request [Rack::Request] The Rack request object.
-    # @param rack_response [Rack::Response] The Rack response object.
-    # @param raise_error [Boolean] Whethir to raise an error if validation fails.
+    # @param request [Rack::Request] The Rack request object.
+    # @param response [Rack::Response] The Rack response object.
+    # @param raise_error [Boolean] Whether to raise an error if validation fails.
     # @return [ValidatedResponse] The validated response object.
-    def validate_response(rack_request, rack_response, raise_error: false)
-      route = @router.match(rack_request.request_method, resolve_path(rack_request),
-                            content_type: rack_request.content_type)
+    def validate_response(request, response, raise_error: false)
+      route = @router.match(request.request_method, resolve_path(request), content_type: request.content_type)
       return if route.error # Skip response validation for unknown requests
 
-      response_match = route.match_response(status: rack_response.status, content_type: rack_response.content_type)
+      response_match = route.match_response(status: response.status, content_type: response.content_type)
       error = response_match.error
       validated = if error
-                    ValidatedResponse.new(rack_response, error:)
+                    ValidatedResponse.new(response, error:)
                   else
-                    response_match.response.validate(rack_response)
+                    response_match.response.validate(response)
                   end
-      @config.after_response_validation&.each { |hook| hook.call(validated, rack_request, self) }
+      @config.after_response_validation&.each { |hook| hook.call(validated, request, self) }
       raise validated.error.exception(validated) if raise_error && validated.invalid?
 
       validated
@@ -104,6 +107,7 @@ def validate_response(rack_request, rack_response, raise_error: false)
     private
 
     def resolve_path(rack_request)
+      return rack_request.path.delete_prefix(path_prefix) if path_prefix && rack_request.path.start_with?(path_prefix)
       return rack_request.path unless @config.path
 
       @config.path.call(rack_request)
diff --git a/spec/definition_spec.rb b/spec/definition_spec.rb
index 41e6dbef..9198f2d6 100644
--- a/spec/definition_spec.rb
+++ b/spec/definition_spec.rb
@@ -266,7 +266,7 @@ def build_request(path, method: 'GET')
       end
     end
 
-    context 'with an alternate path used for schema matching' do
+    context 'with an alternate path for schema matching, from global config' do
       let(:definition) do
         OpenapiFirst.parse(definition_contents) do |config|
           config.path = ->(req) { req.path.delete_prefix('/prefix') }
@@ -280,6 +280,21 @@ def build_request(path, method: 'GET')
         expect(validated.parsed_path_parameters).to eq({ 'id' => 42 })
       end
     end
+
+    context 'with an alternate path for schema matching, from path_prefix' do
+      let(:definition) do
+        OpenapiFirst.parse(definition_contents, path_prefix: '/static_prefix') do |config|
+          config.path = ->(req) { req.path.delete_prefix('/config_prefix') }
+        end
+      end
+
+      it 'returns a valid request, and path_prefix takes precedence over config' do
+        request = build_request('/static_prefix/stuff/42')
+        validated = definition.validate_request(request)
+        expect(validated).to be_valid
+        expect(validated.parsed_path_parameters).to eq({ 'id' => 42 })
+      end
+    end
   end
 
   describe '#validate_response' do
@@ -368,7 +383,7 @@ def build_request(path, method: 'GET')
       end
     end
 
-    context 'with an alternate path used for schema matching' do
+    context 'with an alternate path used for schema matching, from global config' do
       let(:definition) do
         OpenapiFirst.parse(definition_contents) do |config|
           config.path = ->(req) { req.path.delete_prefix('/prefix') }
@@ -378,6 +393,24 @@ def build_request(path, method: 'GET')
       let(:response) { Rack::Response.new(JSON.generate({ 'id' => 42 }), 200, { 'Content-Type' => 'application/json' }) }
 
       it 'returns a valid response' do
+        request = build_request('/prefix/stuff')
+        validated = definition.validate_response(request, response)
+        expect(validated).to be_valid
+        expect(validated.parsed_body).to eq({ 'id' => 42 })
+      end
+    end
+
+    context 'with an alternate path for schema matching, from path_prefix' do
+      let(:definition) do
+        OpenapiFirst.parse(definition_contents, path_prefix: '/static_prefix') do |config|
+          config.path = ->(req) { req.path.delete_prefix('/config_prefix') }
+        end
+      end
+
+      let(:response) { Rack::Response.new(JSON.generate({ 'id' => 42 }), 200, { 'Content-Type' => 'application/json' }) }
+
+      it 'returns a valid response, and path_prefix takes precedence over config' do
+        request = build_request('/static_prefix/stuff')
         validated = definition.validate_response(request, response)
         expect(validated).to be_valid
         expect(validated.parsed_body).to eq({ 'id' => 42 })
diff --git a/spec/openapi_first_spec.rb b/spec/openapi_first_spec.rb
index 545ecb19..ff56eda8 100644
--- a/spec/openapi_first_spec.rb
+++ b/spec/openapi_first_spec.rb
@@ -5,8 +5,6 @@
 require 'rack/test'
 require 'openapi_first'
 
-# frozen_string_literal: true
-
 RSpec.describe OpenapiFirst do
   it 'has a version number' do
     expect(OpenapiFirst::VERSION).not_to be nil
@@ -31,6 +29,13 @@
       expect(paths).not_to include('/pets/{petId}')
     end
 
+    it 'supports :path_prefix' do
+      hash = YAML.safe_load_file('./spec/data/petstore.yaml')
+      path_prefix = '/api/v1'
+      definition = OpenapiFirst.parse(hash, path_prefix:)
+      expect(definition.path_prefix).to eq(path_prefix)
+    end
+
     it 'loads a Hash' do
       definition = OpenapiFirst.parse(YAML.safe_load_file('./spec/data/petstore.yaml'))
       expect(definition.paths).to include('/pets')
@@ -126,5 +131,17 @@
         expect(definition.paths).to eq expected
       end
     end
+
+    describe 'path_prefix option' do
+      specify 'without a path prefix' do
+        definition = OpenapiFirst.load(spec_path, path_prefix: nil)
+        expect(definition.path_prefix).to be_nil
+      end
+
+      specify 'with a path prefix' do
+        definition = OpenapiFirst.load(spec_path, path_prefix: '/api/v1')
+        expect(definition.path_prefix).to eq('/api/v1')
+      end
+    end
   end
 end