diff --git a/src/anthropic/_streaming.py b/src/anthropic/_streaming.py
index a6d0d20db..d4cce68f1 100644
--- a/src/anthropic/_streaming.py
+++ b/src/anthropic/_streaming.py
@@ -11,6 +11,7 @@
 
 import httpx
 
+from ._exceptions import APIConnectionError
 from ._utils import is_dict, extract_type_var_from_base
 
 if TYPE_CHECKING:
@@ -72,7 +73,23 @@ def __iter__(self) -> Iterator[_T]:
             yield item
 
     def _iter_events(self) -> Iterator[ServerSentEvent]:
-        yield from self._decoder.iter_bytes(self.response.iter_bytes())
+        try:
+            yield from self._decoder.iter_bytes(self.response.iter_bytes())
+        except httpx.TimeoutException:
+            # Mid-stream timeouts are already handled by `_base_client._request` for the
+            # initial request, but the SSE body iteration doesn't go through that path —
+            # re-raise as-is so callers can distinguish a hung stream from a dropped one.
+            # APITimeoutError is an APIConnectionError subclass, so customers catching
+            # the latter will still see it; this clause only exists so the next clause
+            # doesn't double-wrap it (TimeoutException is also a TransportError).
+            raise
+        except httpx.TransportError as exc:
+            # Mid-stream transport drops (RemoteProtocolError, ReadError, ConnectError, …)
+            # leak through as bare httpx exceptions because the SDK's wrapping in
+            # `_base_client._request` only covers the pre-body request. Re-wrap them so
+            # `except anthropic.APIConnectionError:` catches mid-stream drops the same way
+            # it catches connection failures, and the original is preserved as `__cause__`.
+            raise APIConnectionError(message=f"Stream interrupted: {exc}", request=self.response.request) from exc
 
     def __stream__(self) -> Iterator[_T]:
         cast_to = cast(Any, self._cast_to)
@@ -226,8 +243,17 @@ async def __aiter__(self) -> AsyncIterator[_T]:
             yield item
 
     async def _iter_events(self) -> AsyncIterator[ServerSentEvent]:
-        async for sse in self._decoder.aiter_bytes(self.response.aiter_bytes()):
-            yield sse
+        try:
+            async for sse in self._decoder.aiter_bytes(self.response.aiter_bytes()):
+                yield sse
+        except httpx.TimeoutException:
+            # See sync `_iter_events` — let timeouts pass through so the next clause
+            # doesn't double-wrap them (TimeoutException is also a TransportError).
+            raise
+        except httpx.TransportError as exc:
+            # See sync `_iter_events` — wrap mid-stream transport drops so
+            # `except anthropic.APIConnectionError:` catches them.
+            raise APIConnectionError(message=f"Stream interrupted: {exc}", request=self.response.request) from exc
 
     async def __stream__(self) -> AsyncIterator[_T]:
         cast_to = cast(Any, self._cast_to)
diff --git a/tests/test_streaming.py b/tests/test_streaming.py
index ac8cc0299..472068251 100644
--- a/tests/test_streaming.py
+++ b/tests/test_streaming.py
@@ -7,7 +7,7 @@
 
 from anthropic import Anthropic, AsyncAnthropic
 from anthropic._streaming import Stream, AsyncStream, ServerSentEvent
-from anthropic._exceptions import APIStatusError
+from anthropic._exceptions import APIConnectionError, APIStatusError
 
 _T = TypeVar("_T")
 
@@ -219,6 +219,68 @@ def body() -> Iterator[bytes]:
     assert sse.json() == {"content": "известни"}
 
 
+@pytest.mark.asyncio
+@pytest.mark.parametrize("sync", [True, False], ids=["sync", "async"])
+async def test_mid_stream_transport_error_is_wrapped(
+    sync: bool,
+    client: Anthropic,
+    async_client: AsyncAnthropic,
+) -> None:
+    """A transport drop mid-SSE-stream (RemoteProtocolError, ReadError, …) raises
+    APIConnectionError with the original httpx exception as __cause__, so that
+    `except anthropic.APIConnectionError:` catches mid-stream drops the same way
+    it catches initial-connection failures.
+    """
+
+    def body() -> Iterator[bytes]:
+        yield b"event: completion\n"
+        yield b'data: {"foo":1}\n'
+        yield b"\n"
+        raise httpx.RemoteProtocolError("peer closed connection without sending complete message body")
+
+    request = httpx.Request("POST", "http://test")
+    if sync:
+        iterator: Iterator[ServerSentEvent] | AsyncIterator[ServerSentEvent] = Stream(
+            cast_to=object, client=client, response=httpx.Response(200, content=body(), request=request)
+        )._iter_events()
+    else:
+        iterator = AsyncStream(
+            cast_to=object, client=async_client, response=httpx.Response(200, content=to_aiter(body()), request=request)
+        )._iter_events()
+
+    # First event arrives normally — the drop is mid-stream, not at connect.
+    sse = await iter_next(iterator)
+    assert sse.event == "completion"
+
+    with pytest.raises(APIConnectionError) as exc_info:
+        await iter_next(iterator)
+    assert isinstance(exc_info.value.__cause__, httpx.RemoteProtocolError)
+    assert "Stream interrupted" in str(exc_info.value)
+
+
+@pytest.mark.asyncio
+@pytest.mark.parametrize("sync", [True, False], ids=["sync", "async"])
+async def test_mid_stream_timeout_is_not_wrapped(
+    sync: bool,
+    client: Anthropic,
+    async_client: AsyncAnthropic,
+) -> None:
+    """TimeoutException is a TransportError subclass, but the wrapping clause must
+    NOT double-wrap it — APITimeoutError already exists for timeouts and is itself
+    an APIConnectionError subclass. The bare httpx.TimeoutException should pass
+    through so callers can map it to APITimeoutError if they want."""
+
+    def body() -> Iterator[bytes]:
+        yield b"event: completion\n"
+        raise httpx.ReadTimeout("read timeout")
+
+    iterator = make_event_iterator(content=body(), sync=sync, client=client, async_client=async_client)
+
+    with pytest.raises(httpx.ReadTimeout):
+        await iter_next(iterator)
+        await iter_next(iterator)
+
+
 @pytest.mark.parametrize("sync", [True, False], ids=["sync", "async"])
 async def test_error_type(
     sync: bool,