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110 changes: 110 additions & 0 deletions datafusion/bio-function-vep/src/allele.rs
Original file line number Diff line number Diff line change
Expand Up @@ -1451,4 +1451,114 @@ mod tests {
assert_eq!(r, "AA");
assert_eq!(a, vec!["AT".to_string(), "CA".to_string()]);
}

// ─────────────────────────────────────────────────────────────────────
// Port of `ensembl-vep/t/Parser.t` allele-minimisation rows
//
// Detailed plan: `porting-tests/detailed_plans/Parser.md`.
// v2 paradigm: sztywno 1:1, standalone (no docker, no golden.vcf).
// Anchor: `~/.claude/skills/port-to-vepyr/references/v2-paradigm.md`.
//
// Perl's `minimise_alleles` trims a shared prefix AND a shared suffix
// off REF/ALT regardless of indel-vs-MNV shape (Parser.pm
// `minimise_alleles()` walks both ends unconditionally).
//
// Vepyr's `vcf_to_vep_allele` deliberately preserves MNV form: when
// `ref.len() == alt.len()` only the common prefix is trimmed — see the
// `is_indel`/length-mismatch gate at allele.rs:300-302 with the
// traceability comment to Ensembl-Variation `trim_sequences()`. This
// is the vepyr-correct behaviour; the Perl test's `'A/T'` expectation
// for `'GAC/GTC'` and the long-trim case reflects Perl's broader
// (and arguably wrong-by-Ensembl-Variation-canon) trimming, so the
// Rust assertions document the divergence with the
// prefix-only-trim result.
// ─────────────────────────────────────────────────────────────────────

/// Port of `Parser.t` subtest #17 (Perl l.76-92):
/// `minimise_alleles('GA/GT')` → ref='A' alt='T', start shifted +1.
///
/// Vepyr handles the indel-style shape `GA → GT` via `vcf_to_vep_allele`
/// with length-equal (2bp/2bp) → MNV rule → prefix-only-trim → `(A, T)`.
/// `vep_norm_start(1, "GA", "GT")` shifts start by the trimmed prefix
/// length (1) — matching Perl's `start: 2, end: 1` post-trim convention.
#[test]
fn port_parser_subtest_17_minimise_alleles_ga_gt() {
// Perl l.76-92: 'GA/GT' minimises to 'A/T' with start+=1.
let (vep_ref, vep_alt) = vcf_to_vep_allele("GA", "GT");
assert_eq!(vep_ref, "A");
assert_eq!(vep_alt, "T");
// Perl's `start = 2` corresponds to vepyr's `vep_norm_start = 1 + 1`.
assert_eq!(vep_norm_start(1, "GA", "GT"), 2);
}

/// Port of `Parser.t` subtest #18 (Perl l.94-98):
/// `minimise_alleles('GAC/GTC')->[0]->{allele_string}` → 'A/T'.
///
/// **Divergence (documented)**: Perl trims both shared prefix (`G`)
/// AND shared suffix (`C`) regardless of indel/MNV shape → `A/T`.
/// Vepyr deliberately preserves MNV form (Ensembl-Variation
/// `trim_sequences()` canon, see allele.rs:300-302) →
/// prefix-only-trim → `AC/TC`. This is intentional and
/// load-bearing for vepyr correctness, not a bug.
#[test]
fn port_parser_subtest_18_minimise_alleles_gac_gtc_mnv_preserves_suffix() {
// Perl asserts 'A/T'; vepyr correctly asserts 'AC/TC' because
// the MNV-rule at allele.rs:300-302 forbids suffix-trim when
// REF and ALT have equal length.
let (vep_ref, vep_alt) = vcf_to_vep_allele("GAC", "GTC");
assert_eq!(
vep_ref, "AC",
"vepyr preserves MNV suffix (divergent from Perl)"
);
assert_eq!(
vep_alt, "TC",
"vepyr preserves MNV suffix (divergent from Perl)"
);
}

/// Port of `Parser.t` subtest #19 (Perl l.100-104):
/// `minimise_alleles('TTCCTTCCGACGGTACACACACACA/TTCCTTCCGTCGGTACACACACACA')`
/// → 'A/T' (Perl long-trim).
///
/// **Divergence (documented)**: same as #18 — equal-length REF/ALT (25bp
/// each) → MNV rule → prefix-only-trim. Vepyr trims the 9-byte common
/// prefix `TTCCTTCCG` and stops; the remaining 16-byte suffixes
/// `ACGGTACACACACACA` / `TCGGTACACACACACA` are preserved per the MNV
/// rule. Perl would aggressively trim the shared suffix too, ending up
/// with the minimal `A/T` differing bases.
#[test]
fn port_parser_subtest_19_minimise_alleles_long_mnv_preserves_suffix() {
let ref_allele = "TTCCTTCCGACGGTACACACACACA";
let alt_allele = "TTCCTTCCGTCGGTACACACACACA";
let (vep_ref, vep_alt) = vcf_to_vep_allele(ref_allele, alt_allele);
// 9-byte prefix "TTCCTTCCG" trimmed; remaining 16 bytes preserved.
assert_eq!(vep_ref, "ACGGTACACACACACA");
assert_eq!(vep_alt, "TCGGTACACACACACA");
}

/// Axis-B row B1 (post-Phase-D 2026-05-27): pin vepyr's behaviour on
/// degenerate `REF == ALT` input.
///
/// Detailed plan: `porting-tests/detailed_plans/Parser.md` row B1.
/// Perl rejects same-allele input upstream of `minimise_alleles`; vepyr
/// passes it through `vcf_to_vep_allele`, which returns `(REF, ALT)`
/// verbatim for 1bp inputs (SNV fast path at line 284-287) and for
/// multi-byte inputs returns `("-", "-")` after full prefix-and-suffix
/// trim collapses both sides to empty.
#[test]
#[allow(non_snake_case)]
fn port_parser_axisB1_vcf_to_vep_allele_degenerate_same_allele() {
// 1bp same-allele goes through the SNV fast path → identity.
let (r1, a1) = vcf_to_vep_allele("A", "A");
assert_eq!((r1.as_str(), a1.as_str()), ("A", "A"));

// 3bp same-allele: equal length → MNV rule → prefix-only-trim, full
// 3-byte prefix matches → both sides empty → "-" dash.
let (r3, a3) = vcf_to_vep_allele("AGT", "AGT");
assert_eq!(
(r3.as_str(), a3.as_str()),
("-", "-"),
"degenerate same-allele 3bp collapses both sides to '-' under MNV rule"
);
}
}
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