diff --git a/.github/workflows/build-binary.yml b/.github/workflows/build-binary.yml
index 8a257da1d..ff97480e9 100644
--- a/.github/workflows/build-binary.yml
+++ b/.github/workflows/build-binary.yml
@@ -21,9 +21,9 @@ jobs:
       - name: Install dependencies
         run: |
           python -m pip install --upgrade pip
-          pip install setuptools wheel twine
-          pip install --no-deps -r requirements.txt
-          pip install -r requirements.txt --no-cache-dir
+          pip install uv
+          uv pip sync --system --no-build pylock.toml
+          uv pip install --system -e .
 
       - name: Build Binary (Linux)
         if: runner.os == 'Linux'
diff --git a/.github/workflows/build-version.yml b/.github/workflows/build-version.yml
index f23872f85..f1cd1cbe2 100644
--- a/.github/workflows/build-version.yml
+++ b/.github/workflows/build-version.yml
@@ -19,9 +19,9 @@ jobs:
       - name: Install dependencies
         run: |
           python -m pip install --upgrade pip
-          pip install setuptools wheel twine
-          pip install --no-deps -r requirements.txt
-          pip install -r requirements.txt --no-cache-dir
+          pip install uv
+          uv pip sync --system --no-build pylock.toml
+          uv pip install --system -e .
       - name: Update CDISC standards cache
         env:
           CDISC_LIBRARY_API_KEY: ${{ secrets.CDISC_LIBRARY_API_KEY }}
@@ -73,9 +73,9 @@ jobs:
 #       - name: Install dependencies
 #         run: |
 #           python -m pip install --upgrade pip
-#           pip install setuptools wheel twine
-#           pip install --no-deps -r requirements.txt
-#           pip install -r requirements.txt --no-cache-dir
+#           pip install uv
+#           uv pip sync --system pylock.toml
+#           uv pip install --system -e .
 #       - name: Update CDISC standards cache
 #         env:
 #           CDISC_LIBRARY_API_KEY: ${{ secrets.CDISC_LIBRARY_API_KEY }}
@@ -117,9 +117,9 @@ jobs:
 #       - name: Install dependencies
 #         run: |
 #           python -m pip install --upgrade pip
-#           pip install setuptools wheel twine
-#           pip install --no-deps -r requirements.txt
-#           pip install -r requirements.txt --no-cache-dir
+#           pip install uv
+#           uv pip sync --system pylock.toml
+#           uv pip install --system -e .
 #       - name: Update CDISC standards cache
 #         env:
 #           CDISC_LIBRARY_API_KEY: ${{ secrets.CDISC_LIBRARY_API_KEY }}
diff --git a/.github/workflows/lint-format.yml b/.github/workflows/lint-format.yml
index 4c7f70fe0..f455d0b78 100644
--- a/.github/workflows/lint-format.yml
+++ b/.github/workflows/lint-format.yml
@@ -49,7 +49,7 @@ jobs:
           python-version: "3.12"
       - name: Install linters
         run: |
-          pip install black flake8 -c requirements-dev.txt
+          pip install black flake8
       - name: Run flake8
         run: |
           flake8 ${{needs.get_changed_files.outputs.py}} --count --select=E9,F63,F7,F82 --show-source --statistics
diff --git a/.github/workflows/prerelease-update-cache.yml b/.github/workflows/prerelease-update-cache.yml
index ba225f5d1..4012e0c7a 100644
--- a/.github/workflows/prerelease-update-cache.yml
+++ b/.github/workflows/prerelease-update-cache.yml
@@ -23,7 +23,10 @@ jobs:
           python-version: "3.12"
 
       - name: Install requirements
-        run: pip install -r requirements.txt
+        run: |
+          pip install uv
+          uv pip sync --system --no-build pylock.toml
+          pip install -e .
 
       - name: Run Update Cache Script
         run: python core.py update-cache
diff --git a/.github/workflows/release.yml b/.github/workflows/release.yml
index f3b8258e2..aaa027692 100644
--- a/.github/workflows/release.yml
+++ b/.github/workflows/release.yml
@@ -102,8 +102,9 @@ jobs:
       - name: Install dependencies
         run: |
           python -m pip install --upgrade pip
-          pip install build setuptools wheel twine
-          pip install -r requirements.txt
+          pip install uv build twine
+          uv pip sync --system --no-build pylock.toml
+          uv pip install --system -e .
       - name: Build package
         run: |
           python -m build
diff --git a/.github/workflows/test-release.yml b/.github/workflows/test-release.yml
index bd3a60802..2441c2fcb 100644
--- a/.github/workflows/test-release.yml
+++ b/.github/workflows/test-release.yml
@@ -81,8 +81,10 @@ jobs:
       - name: Install dependencies
         run: |
           python -m pip install --upgrade pip
-          pip install build setuptools wheel twine
-          pip install -r requirements.txt
+          pip install uv build twine
+          uv pip sync --system --no-build pylock.toml
+          uv pip install --system -e .
+
 
       - name: Build package
         run: |
diff --git a/.github/workflows/test-suite.yml b/.github/workflows/test-suite.yml
index 0e33d67bd..2d32d1577 100644
--- a/.github/workflows/test-suite.yml
+++ b/.github/workflows/test-suite.yml
@@ -28,7 +28,9 @@ jobs:
           python-version: "3.12"
       - name: Install dependencies
         run: |
-          pip install -r requirements.txt
+          pip install uv
+          uv pip sync --system --no-build pylock.toml
+          uv pip install --system -e .
       - name: Update rules cache
         env:
           CDISC_LIBRARY_API_KEY: ${{ secrets.CDISC_LIBRARY_API_KEY }}
diff --git a/.github/workflows/test-unit.yml b/.github/workflows/test-unit.yml
index 38a9e55ae..507a6d70e 100644
--- a/.github/workflows/test-unit.yml
+++ b/.github/workflows/test-unit.yml
@@ -16,8 +16,9 @@ jobs:
           python-version: "3.12"
       - name: Install requirements
         run: |
-          pip install -r requirements-dev.txt
-          pip install -e .
+          pip install uv
+          uv pip sync --system --no-build pylock.dev.toml
+          uv pip install --system -e .
       - name: Running Tests
         env:
           CDISC_LIBRARY_API_KEY: fakekey12341234
diff --git a/.github/workflows/validate-published-rules.yml b/.github/workflows/validate-published-rules.yml
index 1c68f210c..814c57820 100644
--- a/.github/workflows/validate-published-rules.yml
+++ b/.github/workflows/validate-published-rules.yml
@@ -80,9 +80,9 @@ jobs:
       - name: Install engine dependencies
         run: |
           python -m venv venv
-          ./venv/bin/pip install --upgrade pip
-          ./venv/bin/pip install -r engine/requirements.txt
-
+          venv/bin/pip install uv
+          venv/bin/uv pip sync --no-build pylock.dev.toml
+          venv/bin/uv pip install -e .
       # -----------------------------------------------------------------------
       # 5. Run validation for every Published rule
       # -----------------------------------------------------------------------
diff --git a/cdisc_rules_engine/dataset_builders/contents_define_vlm_dataset_builder.py b/cdisc_rules_engine/dataset_builders/contents_define_vlm_dataset_builder.py
index fb2374b9c..328a90e48 100644
--- a/cdisc_rules_engine/dataset_builders/contents_define_vlm_dataset_builder.py
+++ b/cdisc_rules_engine/dataset_builders/contents_define_vlm_dataset_builder.py
@@ -66,7 +66,7 @@ def build(self):
         data_contents_with_vlm["variable_value_length"] = data_contents_with_vlm.data[
             ["variable_value", "define_vlm_data_type"]
         ].apply(
-            lambda row: self.calculate_variable_value_length(
+            lambda row: ValuesDatasetBuilder.calculate_variable_value_length(
                 row["variable_value"], row["define_vlm_data_type"]
             ),
             axis=1,
diff --git a/cdisc_rules_engine/operations/codelist_extensible.py b/cdisc_rules_engine/operations/codelist_extensible.py
index 62cd7b56f..f5e24cf41 100644
--- a/cdisc_rules_engine/operations/codelist_extensible.py
+++ b/cdisc_rules_engine/operations/codelist_extensible.py
@@ -32,6 +32,10 @@ def _handle_multiple_versions(self) -> pd.Series:
                 "codelist_code": "string",
             }
         )
+        cast_cols = {self.params.ct_version: str}
+        if self.params.codelist_code in self.evaluation_dataset.columns:
+            cast_cols[self.params.codelist_code] = str
+        self.evaluation_dataset = self.evaluation_dataset.astype(cast_cols)
         if self.params.codelist_code in self.evaluation_dataset.columns:
             is_extensible = self.evaluation_dataset.merge(
                 ct_df.data,
diff --git a/cdisc_rules_engine/operations/codelist_terms.py b/cdisc_rules_engine/operations/codelist_terms.py
index 90a0a6d18..e2fbba0b6 100644
--- a/cdisc_rules_engine/operations/codelist_terms.py
+++ b/cdisc_rules_engine/operations/codelist_terms.py
@@ -60,10 +60,14 @@ def _handle_multiple_versions(self) -> pd.Series:
         ct_df = self.evaluation_dataset.__class__.from_dict(ct_data)
         ct_df = ct_df.astype(
             {
-                "version": "string",
-                "codelist_code": "string",
+                "version": str,
+                "codelist_code": str,
             }
         )
+        cast_cols = {self.params.ct_version: "string"}
+        if self.params.codelist_code in self.evaluation_dataset.columns:
+            cast_cols[self.params.codelist_code] = "string"
+        self.evaluation_dataset = self.evaluation_dataset.astype(cast_cols)
         if self.params.codelist_code in self.evaluation_dataset.columns:
             result = self.evaluation_dataset.merge(
                 ct_df.data,
diff --git a/cdisc_rules_engine/services/data_readers/csv_reader.py b/cdisc_rules_engine/services/data_readers/csv_reader.py
index ae8aa90d0..901e6d695 100644
--- a/cdisc_rules_engine/services/data_readers/csv_reader.py
+++ b/cdisc_rules_engine/services/data_readers/csv_reader.py
@@ -1,6 +1,6 @@
 import tempfile
 
-from dask.dataframe import dd
+import dask.dataframe as dd
 
 from cdisc_rules_engine.exceptions.custom_exceptions import InvalidCSVFile
 from cdisc_rules_engine.interfaces import DataReaderInterface
diff --git a/cdisc_rules_engine/services/data_services/usdm_data_service.py b/cdisc_rules_engine/services/data_services/usdm_data_service.py
index 34ebe2285..e7950eed7 100644
--- a/cdisc_rules_engine/services/data_services/usdm_data_service.py
+++ b/cdisc_rules_engine/services/data_services/usdm_data_service.py
@@ -399,8 +399,8 @@ def __read_node_metadata(
         }
 
     @staticmethod
-    def __get_full_path(node: DatumInContext):
-        return f"{node.full_path}".replace(".[", "[")
+    def __get_full_path(node: DatumInContext) -> str:
+        return str(node.full_path).replace(".[", "[")
 
     def __get_datasets_content_index(self) -> List[dict]:
         """
diff --git a/cdisc_rules_engine/services/datasetxpt_metadata_reader.py b/cdisc_rules_engine/services/datasetxpt_metadata_reader.py
index f20506c91..b96dc4540 100644
--- a/cdisc_rules_engine/services/datasetxpt_metadata_reader.py
+++ b/cdisc_rules_engine/services/datasetxpt_metadata_reader.py
@@ -61,7 +61,7 @@ def read(self) -> dict:
             "variable_labels": list(metadata.column_labels),
             "variable_names": list(metadata.column_names),
             "variable_formats": [
-                "" if data_type == "NULL" else data_type
+                "" if (data_type == "NULL" or data_type is None) else data_type
                 for data_type in metadata.original_variable_types.values()
             ],
             "variable_name_to_label_map": metadata.column_names_to_labels,
diff --git a/core.py b/core.py
index 98f0a5a70..ea660b867 100644
--- a/core.py
+++ b/core.py
@@ -357,7 +357,6 @@ def load_custom_dotenv_from_data_options(_ctx, _param, value):
     "-s",
     "--standard",
     required=True,
-    default=None,
     help="CDISC standard to validate against",
     envvar="PRODUCT",
 )
@@ -365,7 +364,6 @@ def load_custom_dotenv_from_data_options(_ctx, _param, value):
     "-v",
     "--version",
     required=True,
-    default=None,
     help="Standard version to validate against",
     envvar="VERSION",
 )
diff --git a/docs/contributing.md b/docs/contributing.md
index d53a3315e..f087b60b9 100644
--- a/docs/contributing.md
+++ b/docs/contributing.md
@@ -34,7 +34,7 @@ This project enforces consistent formatting and linting via pre-commit hooks.
 - [`flake8`](https://flake8.pycqa.org/) — Python linter
 - [`prettier`](https://prettier.io/) — JSON, YAML, and Markdown formatter
 
-Both `black` and `flake8` are included in `requirements-dev.txt`. After installing dependencies, install the pre-commit hooks:
+Both `black` and `flake8` are included in the `dev` dependency group in `pyproject.toml`. After installing dependencies, install the pre-commit hooks:
 
 ```bash
 pre-commit install
diff --git a/docs/development.md b/docs/development.md
index bb4c27427..fb920f0d8 100644
--- a/docs/development.md
+++ b/docs/development.md
@@ -46,10 +46,21 @@ source venv/bin/activate
 # Activate (Windows)
 .\venv\Scripts\Activate
 
-# Install dependencies
-python -m pip install -r requirements-dev.txt
+# Install uv (if not already installed)
+pip install uv
+
+# Install pinned dependencies from the primary & dev lockfiles
+uv pip sync pylock.dev.toml
+
+# Install the package itself in editable mode
+pip install -e.
 ```
 
+> **Note:** `pylock.toml` and `pylock.dev.toml` are standard lockfiles (PEP 751) and can be used
+> with any compatible tool. If you prefer not to use uv, you can install core dependencies via
+> standard pip (`pip install .`), though dev dependencies will need to be installed separately
+> and exact version pinning is only guaranteed when using a tool that supports `pylock.toml`.
+
 ---
 
 ## Running Tests
diff --git a/docs/quick-start.md b/docs/quick-start.md
index 0b810ae20..0fcd6cc50 100644
--- a/docs/quick-start.md
+++ b/docs/quick-start.md
@@ -125,9 +125,15 @@ python -m venv venv
 ### 3. Install Dependencies
 
 ```bash
-python -m pip install -r requirements-dev.txt
+pip install uv
+uv pip sync pylock.toml
 ```
 
+> **Note:** `pylock.toml` is a standard format (PEP 751) and can be used with any compatible tool.
+> If you prefer not to use uv, you can install directly from `pyproject.toml` using standard pip
+> (`pip install .`) or any other PEP 517-compatible tool such as pip-tools or Poetry. Note that
+> exact version pinning is only guaranteed when using a tool that supports `pylock.toml`.
+
 ### 4. Populate the Cache
 
 ```bash
diff --git a/pylock.dev.toml b/pylock.dev.toml
new file mode 100644
index 000000000..7cbaea02c
--- /dev/null
+++ b/pylock.dev.toml
@@ -0,0 +1,518 @@
+# This file was autogenerated by uv via the following command:
+#    uv pip compile pyproject.toml --group dev -o pylock.dev.toml
+lock-version = "1.0"
+created-by = "uv"
+requires-python = ">=3.12.10"
+
+[[packages]]
+name = "altgraph"
+version = "0.17.5"
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diff --git a/pyproject.toml b/pyproject.toml
index bb4d69066..7418ff68c 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -4,12 +4,49 @@ build-backend = "setuptools.build_meta"
 
 [project]
 name = "cdisc-rules-engine"
-dynamic = ["version", "dependencies"]
+dynamic = ["version"]
 description = "Open source offering of the cdisc rules engine"
 readme = "docs/PYPI.md"
 requires-python = ">=3.12, <3.13"
 license = { text = "MIT" }
 authors = [{ name = "cdisc-org", email = "info@cdisc.org" }]
+dependencies = [
+    "business_rules_enhanced >=1.4.8",
+    "cachetools >=6.1.0",
+    "cdisc-library-client >=0.1.6",
+    "click >=8.1.7",
+    "dask[dataframe,array] >=2024.6.0",
+    "fastparquet >=2024.2.0",
+    "importlib-metadata >=8.5.0",
+    "jsonata-python >=0.6.0",
+    "jsonpath-ng >=1.6.1",
+    "jsonschema >=4.18.5",
+    "lxml >=5.2.1",
+    "numpy >=1.26.0",
+    "odmlib >=0.1.4",
+    "openpyxl >=3.1.5",
+    "pandas >=2.1.4, <3.0.0",
+    "psutil >=6.1.1",
+    "pyinstaller >=6.11.0",
+    "pympler >=1.1",
+    "pyreadstat >=1.2.7",
+    "python-dotenv >=1.0.0",
+    "pyyaml >=6.0.2",
+    "redis >=4.5.0",
+    "requests >=2.32.3",
+    "setuptools >=75.6.0",
+    "titlecase >=2.4.1",
+]
+
+[dependency-groups]
+dev = [
+    "black >=24.10.0",
+    "flake8 >=6.1.0",
+    "pre-commit >=2.20.0",
+    "pytest >=7.4.0, <8.0.0",
+    "pytest-asyncio >=0.21.0",
+    "pytest-cov >=6.0.0",
+]
 
 [project.urls]
 "Homepage" = "https://github.com/cdisc-org/cdisc-rules-engine"
@@ -26,5 +63,4 @@ include-package-data = true
 py-modules = ["version"]
 
 [tool.setuptools.dynamic]
-version = { attr = "version.__version__" }
-dependencies = {file = ["requirements.txt"]}
\ No newline at end of file
+version = { attr = "version.__version__" }
\ No newline at end of file
diff --git a/requirements-dev.txt b/requirements-dev.txt
deleted file mode 100644
index ac709f651..000000000
--- a/requirements-dev.txt
+++ /dev/null
@@ -1,7 +0,0 @@
--r requirements.txt
-black==24.10.0
-flake8==6.1.0
-pre-commit==2.20.0
-pytest==7.4.0
-pytest-asyncio==0.21.0
-pytest-cov==6.0.0
\ No newline at end of file
diff --git a/requirements.txt b/requirements.txt
deleted file mode 100644
index 4481051f6..000000000
--- a/requirements.txt
+++ /dev/null
@@ -1,26 +0,0 @@
-business_rules_enhanced==1.4.8
-cachetools==6.1.0
-cdisc-library-client==0.1.6
-click==8.1.7
-dask[dataframe]==2024.6.0
-dask[array]==2024.6.0
-fastparquet==2024.2.0
-importlib-metadata==8.5.0
-jsonata-python==0.6.0
-jsonpath-ng==1.6.1
-jsonschema==4.18.5
-lxml==5.2.1
-numpy~=1.26.0
-odmlib==0.1.4
-openpyxl==3.1.5
-pandas==2.1.4
-psutil==6.1.1
-pyinstaller==6.11.0
-Pympler==1.1
-pyreadstat==1.2.7
-python-dotenv==1.0.0
-pyyaml==6.0.2
-redis==4.5.0
-requests~=2.32.3
-setuptools~=75.6.0
-titlecase==2.4.1
\ No newline at end of file
diff --git a/tests/unit/test_dataset_builders/test_dataset_metadata_define_dataset_builder.py b/tests/unit/test_dataset_builders/test_dataset_metadata_define_dataset_builder.py
index aff6c25e8..dad459b54 100644
--- a/tests/unit/test_dataset_builders/test_dataset_metadata_define_dataset_builder.py
+++ b/tests/unit/test_dataset_builders/test_dataset_metadata_define_dataset_builder.py
@@ -11,7 +11,6 @@
 )
 from cdisc_rules_engine.models.dataset.pandas_dataset import PandasDataset
 
-
 define_metadata = [
     {
         "define_dataset_name": "TS",
@@ -143,15 +142,24 @@ def test_dataset_metadata_define_dataset_builder(dataset_path):
 
         result = builder.build()
 
-    expected_df = pd.DataFrame(
-        [
-            expected_results["ts.xpt"],
-            expected_results["dm.xpt"],
-            expected_results["ae.xpt"],
-        ]
-    ).astype(object)
+    expected_df = (
+        pd.DataFrame(
+            [
+                expected_results["ts.xpt"],
+                expected_results["dm.xpt"],
+                expected_results["ae.xpt"],
+            ]
+        )
+        .astype(object)
+        .sort_values("dataset_location")
+        .reset_index(drop=True)
+    )
 
-    result_df = result.data[expected_df.columns].reset_index(drop=True)
+    result_df = (
+        result.data[expected_df.columns]
+        .sort_values("dataset_location")
+        .reset_index(drop=True)
+    )
 
     # Check that columns are the same
     assert list(result_df.columns) == list(expected_df.columns), "Columns do not match"