diff --git a/src/handlers/response-interceptor.ts b/src/handlers/response-interceptor.ts
index cacadfb0..a12070d9 100644
--- a/src/handlers/response-interceptor.ts
+++ b/src/handlers/response-interceptor.ts
@@ -13,6 +13,23 @@ type Interceptor<TReq = http.IncomingMessage, TRes = http.ServerResponse> = (
   res: TRes,
 ) => Promise<Buffer | string>;
 
+/**
+ * Disallow headers when response contains trailer
+ * source: https://developer.mozilla.org/docs/Web/HTTP/Headers/Trailer
+ */
+const TrailerDisallowHeaders: string[] = [
+  'content-length',
+  'host',
+  'content-type',
+  'authorization',
+  'cache-control',
+  'max-forwards',
+  'te',
+  'set-cookie',
+  'content-encoding',
+  'content-range',
+];
+
 /**
  * Intercept responses from upstream.
  * Automatically decompress (deflate, gzip, brotli).
@@ -49,8 +66,14 @@ export function responseInterceptor<
 
       // set correct content-length (with double byte character support)
       debug('set content-length: %s', Buffer.byteLength(interceptedBuffer, 'utf8'));
-      res.setHeader('content-length', Buffer.byteLength(interceptedBuffer, 'utf8'));
-
+      // some headers are disallowed when response headers contains trailer
+      if (proxyRes.headers.trailer === undefined) {
+        res.setHeader('content-length', Buffer.byteLength(interceptedBuffer, 'utf8'));
+      } else {
+        TrailerDisallowHeaders.forEach((value) => {
+          res.removeHeader(value);
+        });
+      }
       debug('write intercepted response');
       res.write(interceptedBuffer);
       res.end();
diff --git a/test/e2e/response-interceptor.spec.ts b/test/e2e/response-interceptor.spec.ts
index dc11b6d4..4f675912 100644
--- a/test/e2e/response-interceptor.spec.ts
+++ b/test/e2e/response-interceptor.spec.ts
@@ -31,6 +31,15 @@ describe('responseInterceptor()', () => {
         'content-type': 'image/png',
       });
 
+      await targetServer
+        .forGet('/response-headers')
+        .withExactQuery('?Trailer=X-Stream-Error&Host=localhost')
+        .thenReply(200, '', {
+          'transfer-encoding': 'chunked',
+          trailer: 'X-Stream-Error',
+          host: 'localhost',
+        });
+
       agent = request(
         createApp(
           createProxyMiddleware({
@@ -65,6 +74,13 @@ describe('responseInterceptor()', () => {
       const response = await agent.get(`/json`).expect(200);
       expect(response.body.favorite).toEqual('叉燒包');
     });
+
+    it('should not contains disallow headers to trailer in response headers', async () => {
+      const response = await agent
+        .get('/response-headers?Trailer=X-Stream-Error&Host=localhost')
+        .expect(200);
+      expect(response.header['host']).toBeUndefined();
+    });
   });
 
   describe('intercept responses with original headers', () => {