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Copy file name to clipboardExpand all lines: content/about/_index.md
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## Impact
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Cytomining tools have been adopted across academia and industry for large-scale drug discovery and functional genomics.
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`pycytominer` underpins some of the largest publicly available image-based profiling datasets, including the [JUMP Cell Painting dataset](https://jump-cellpainting.broadinstitute.org/) (over 136,000 chemical and genetic perturbations profiled across 12 partner sites) the [LINCS Drug Repurposing](https://github.com/broadinstitute/lincs-cell-painting) Cell Painting dataset, and the [EU-OPENSCREEN](https://www.eu-openscreen.eu/) Bioactive Compound Set profiled across multiple imaging sites.
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`Pycytominer` underpins some of the largest publicly available image-based profiling datasets, including the [JUMP Cell Painting dataset](https://jump-cellpainting.broadinstitute.org/) (over 136,000 chemical and genetic perturbations profiled across 12 partner sites) the [LINCS Drug Repurposing](https://github.com/broadinstitute/lincs-cell-painting) Cell Painting dataset, and the [EU-OPENSCREEN](https://www.eu-openscreen.eu/) Bioactive Compound Set profiled across multiple imaging sites.
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It has also processed many of the 31+ datasets in the [Cell Painting Gallery](https://broadinstitute.github.io/cellpainting-gallery/).
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The foundational [Caicedo et al. 2017](https://doi.org/10.1038/nmeth.4397) review has accumulated over 670 citations, and individual tool papers have together been cited more than 150 times since 2024.
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In 2016, members of this community co-founded the [CytoData Society](https://www.cytodata.org/) to unite researchers across academia and industry around image-based profiling.
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The following year, the team contributed the landmark [Caicedo et al. 2017](https://doi.org/10.1038/nmeth.4397) review in _Nature Methods_ that established the field's foundational analysis standards.
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Since 2021, the [Way Lab](https://www.waysciencelab.com/) has driven a major expansion of the ecosystem — migrating from R to Python with `pycytominer` and building a modern infrastructure stack including `CytoTable` and `coSMicQC`.
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Since 2021, the [Way Lab](https://www.waysciencelab.com/) has driven a major expansion of the ecosystem — migrating from R to Python with `Pycytominer` and building a modern infrastructure stack including `CytoTable` and `coSMicQC`.
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Today, Cytomining tools are used by research groups worldwide for drug discovery, functional genomics, and cell biology.
**Problem:** Population-level hit calling averages away biologically meaningful cell-to-cell variation, making heterogeneous responses and rare subpopulations invisible to standard metrics.
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`buscar` scores perturbations directly on single-cell distributions using Earth Mover's Distance, preserving heterogeneity throughout hit calling.
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**Problem:** Population-level hit calling averages away biologically meaningful cell-to-cell variation, making heterogeneous responses and rare subpopulations invisible to standard metrics.
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**Key capabilities:**
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- Define on-target and off-target morphology signatures from reference profiles
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- Score perturbation efficacy via Earth Mover's Distance
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- Assess specificity with off-target scoring to reduce false positives
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- Preserve single-cell heterogeneity throughout hit calling
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- Integrates directly with `pycytominer`, `coSMicQC`, and `CytoTable` workflows
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- Integrates directly with `Pycytominer`, `coSMicQC`, and `CytoTable` workflows
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**[View on GitHub →](https://github.com/WayScience/buscar)**
**Problem:** Raw bioimaging archives have no standard catalog — finding, versioning, and joining images to downstream data requires bespoke scripts per lab.
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`iceberg-bioimage` scans any image store into a versioned Apache Iceberg catalog that directly exports Cytomining-compatible Parquet warehouses.
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**Problem:** Raw bioimaging archives have no standard catalog — finding, versioning, and joining images to downstream data requires bespoke scripts per lab.
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**Key capabilities:**
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- Scan image stores into canonical `ScanResult` objects
**Problem:** Images and feature tables live in separate systems — linking a numeric outlier back to its source cell requires error-prone manual joins across formats.
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`OME-arrow` embeds images as first-class columns in Apache Arrow tables, so features, metadata, and pixel data travel together and can be queried or exported as tensors.
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**Problem:** Images and feature tables live in separate systems — linking a numeric outlier back to its source cell requires error-prone manual joins across formats.
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**Key capabilities:**
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- Store images, metadata, and derived features together in a single table
Copy file name to clipboardExpand all lines: content/experimental/zedprofiler.md
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---
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**Problem:** Classical profiling tools extract only 2D features, leaving organoid, cleared-tissue, and z-stack experiments without a CPU-efficient extractor.
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`zedprofiler` extracts morphological features directly from 3D volumetric images, including anisotropic voxel spacing correction — no GPU required.
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**Problem:** Classical profiling tools extract only 2D features, leaving organoid, cleared-tissue, and z-stack experiments without a CPU-efficient extractor.
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**Key capabilities:**
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- Extract features from 3D volumetric (z-stack) single-cell images
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