diff --git a/src/coreclr/clrfeatures.cmake b/src/coreclr/clrfeatures.cmake
index 7b87cefead0c25..55d3a3c070ca3b 100644
--- a/src/coreclr/clrfeatures.cmake
+++ b/src/coreclr/clrfeatures.cmake
@@ -46,14 +46,21 @@ if(NOT DEFINED FEATURE_DBGIPC)
   endif()
 endif(NOT DEFINED FEATURE_DBGIPC)
 
-# ICorProfiler is supported by default
-set(FEATURE_CORPROFILER 1)
+if(NOT DEFINED FEATURE_CORPROFILER)
+  # ICorProfiler isn't supported on non-desktop targets or WASM scenarios
+  if(NOT CLR_CMAKE_TARGET_ARCH_WASM
+    # AND NOT CLR_CMAKE_TARGET_ANDROID
+    # AND NOT CLR_CMAKE_TARGET_MACCATALYST
+    # AND NOT CLR_CMAKE_TARGET_IOS
+    AND NOT CLR_CMAKE_TARGET_TVOS)
+    set(FEATURE_CORPROFILER 1)
+  endif()
+endif()
 
 if(CLR_CMAKE_TARGET_ARCH_WASM)
   # FEATURE_INTERPRETER is already enabled by default
   set(FEATURE_PORTABLE_ENTRYPOINTS 1)
   set(FEATURE_PORTABLE_HELPERS 1)
-  set(FEATURE_CORPROFILER 0)
 endif(CLR_CMAKE_TARGET_ARCH_WASM)
 
 if(CLR_CMAKE_TARGET_BROWSER)