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                    <h1>Action potential alterations and cell-type specific activity through ictal recruitment in humans</h1>
                    <h3><u>E.M. Merricks</u>, E.H. Smith, G.M. McKhann, II, R.R. Goodman, S.A. Sheth, B. Greger, P.A. House, A.J. Trevelyan, C.A. Schevon</h3>
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                    <h2>Affiliations &amp; Contact</h2>
                    <b>EMM, CAS</b>: Dept. Neurology, Columbia University Medical Center; <b>EHS</b>: Dept. Neurosurgery, University of Utah; <b>GMM</b>: Dept. Neurological Surgery, Columbia University Medical Center; <b>RRG</b>: Dept. Neurosurgery, Icahn School of Medicine at Mount Sinai; <b>SAS</b>: Baylor College of Medicine; <b>BG</b>: School of Engineering, Arizona State University; <b>PAH</b>: Intermountain Healthcare, UT; <b>AJT</b>: Institute of Neuroscience, Newcastle University, UK<hr />
                    <b>Contact:</b><br />
                    <i>em3217@cumc.columbia.edu</i> (<b>EMM</b>)&nbsp;/&nbsp;<i>cas2044@cumc.columbia.edu</i> (<b>CAS</b>)
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                    <h2>References</h2>
                    <ol>
                        <li>Bower, M.R., <i>et al.</i> (2012) <i>Epilepsia</i>. 53 (5), 807&mdash;816.</li>
						<li>Goldensohn, E.S. &amp; Purpura, D.P. (1963) <i>Science</i>. 139 (3557), 840&mdash;2.</li>
                        <li>Merricks, E.M., <i>et al.</i> (2015) <i>Brain</i>. 138 (10), 2891&mdash;2906.</li>
                        <li>Miri, M.L., <i>et al.</i> (2018) <i>eLife</i>. 7, e40750.</li>
                        <li>Misra, A., <i>et al.</i> (2014) <i>J Neural Eng</i>. 11 (2), 026013.</li>
						<li>Schevon, C.A., <i>et al.</i> (2012) <i>Nat Commun</i>. 3 (1), 1060.</li>
                        <li>Traub, R.D. &amp; Wong, R.K. (1982) <i>Science</i>. 216 (4547), 745&mdash;747.</li>
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                    <h2>Conclusions</h2>
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                        <li>Waveform alterations found during seizures are enough to cause traditional cluster cutting to fail.  Single units can be traced through the ictal transition using a combination of template matching and waveform similarity metrics</li>
                        <li>The distinction between tissue that has been recruited to the seizure versus penumbra is maintained at the level of single neurons. Waveshape changes are a suitable proxy for ictal recruitment and are in keeping with the paroxysmal depolarizing shift (Traub &amp; Wong, 1982)</li>
                        <li>Interneuronal firing was maintained throughout all recruited seizures (<i>n</i> = 7; 4 patients), suggesting that a process such as altered GABAergic conductance or K<sup>+</sup> concentration is responsible for inhibitory failure that permits ictal recruitment</li>
                        <li>Transient out-of-phase firing in interneurons with respect to low frequency rhythms suggests effects from the approaching seizure</li>
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