diff --git a/.github/actions/environment/action.yml b/.github/actions/environment/action.yml
index 3820c61c4a..2a08e3d095 100644
--- a/.github/actions/environment/action.yml
+++ b/.github/actions/environment/action.yml
@@ -24,6 +24,14 @@ runs:
       shell: bash
       run: sudo chmod 666 /var/run/docker.sock
 
+    - name: Install Linux ARM 32-bit dependencies
+      if: ${{ matrix.rid == 'linux-arm' }}
+      shell: bash
+      run: |
+        sudo dpkg --add-architecture armhf
+        sudo apt-get update
+        sudo apt-get install -y gcc-arm-linux-gnueabihf libc6:armhf
+
     # zstd is needed for cross OS actions/cache but missing from windows-11-arm
     # https://github.com/actions/partner-runner-images/issues/99
     - name: Install zstd on Windows ARM64
diff --git a/.github/workflows/build.yml b/.github/workflows/build.yml
index bcb5af4243..731ec91d3b 100644
--- a/.github/workflows/build.yml
+++ b/.github/workflows/build.yml
@@ -281,6 +281,47 @@ jobs:
             msbuild.binlog
           if-no-files-found: ignore
 
+  # Unsupported Native AOT runtimes should have SentryNative auto-disabled
+  # to avoid native library loading errors on startup.
+  unsupported-aot:
+    needs: build
+    name: Unsupported AOT (${{ matrix.rid }})
+    runs-on: ${{ matrix.os }}
+
+    strategy:
+      fail-fast: false
+      matrix:
+        include:
+          - os: ubuntu-24.04-arm
+            rid: linux-arm
+          - os: windows-latest
+            rid: win-x86
+
+    steps:
+      - name: Checkout
+        uses: actions/checkout@v4
+        with:
+          submodules: recursive
+
+      - name: Setup Environment
+        uses: ./.github/actions/environment
+
+      - name: Build Native Dependencies
+        uses: ./.github/actions/buildnative
+
+      - name: Fetch NuGet Packages
+        uses: actions/download-artifact@v4
+        with:
+          name: ${{ github.sha }}
+          path: src
+
+      - name: Test AOT
+        uses: getsentry/github-workflows/sentry-cli/integration-test/@v2
+        env:
+          RuntimeIdentifier: ${{ matrix.rid }}
+        with:
+          path: integration-test/aot.Tests.ps1
+
   trim-analysis:
     needs: build-sentry-native
     name: Trim analysis
diff --git a/CHANGELOG.md b/CHANGELOG.md
index e04f22bc4f..3758187a1f 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -2,6 +2,10 @@
 
 ## Unreleased
 
+### Fixes
+
+- Native AOT: don't load SentryNative on unsupported platforms ([#4347](https://github.com/getsentry/sentry-dotnet/pull/4347))
+
 ### Dependencies
 
 - Bump CLI from v2.47.0 to v2.47.1 ([#4348](https://github.com/getsentry/sentry-dotnet/pull/4348))
diff --git a/integration-test/aot.Tests.ps1 b/integration-test/aot.Tests.ps1
index 24dbc8e800..14849c332f 100644
--- a/integration-test/aot.Tests.ps1
+++ b/integration-test/aot.Tests.ps1
@@ -50,11 +50,22 @@ Console.WriteLine("Hello, Sentry!");
     }
 
     It 'Aot' {
-        dotnet publish -c Release | Write-Host
+        $rid = $env:RuntimeIdentifier
+        if ($rid)
+        {
+            dotnet publish -c Release -r $rid | Write-Host
+        }
+        else
+        {
+            dotnet publish -c Release | Write-Host
+        }
         $LASTEXITCODE | Should -Be 0
 
         $tfm = (Get-ChildItem -Path "bin/Release" -Directory | Select-Object -First 1).Name
-        $rid = (Get-ChildItem -Path "bin/Release/$tfm" -Directory | Select-Object -First 1).Name
+        if (-not $rid)
+        {
+            $rid = (Get-ChildItem -Path "bin/Release/$tfm" -Directory | Select-Object -First 1).Name
+        }
         & "bin/Release/$tfm/$rid/publish/hello-sentry" | Write-Host
         $LASTEXITCODE | Should -Be 0
     }
diff --git a/src/Sentry/Platforms/Native/SentryNative.cs b/src/Sentry/Platforms/Native/SentryNative.cs
index ed0c5cbbbc..c624d69e78 100644
--- a/src/Sentry/Platforms/Native/SentryNative.cs
+++ b/src/Sentry/Platforms/Native/SentryNative.cs
@@ -17,7 +17,7 @@ internal static class SentryNative
     // This way, `SentryNative.IsEnabled` should be treated as a compile-time constant for trimmed apps.
     [FeatureSwitchDefinition(SentryNativeIsEnabledSwitchName)]
 #endif
-    private static bool IsEnabled => !AppContext.TryGetSwitch(SentryNativeIsEnabledSwitchName, out var isEnabled) || isEnabled;
+    private static bool IsEnabled => AppContext.TryGetSwitch(SentryNativeIsEnabledSwitchName, out var isEnabled) && isEnabled;
 
     internal static bool IsAvailable => IsEnabled && IsAvailableCore;
 
diff --git a/src/Sentry/Platforms/Native/buildTransitive/Sentry.Native.targets b/src/Sentry/Platforms/Native/buildTransitive/Sentry.Native.targets
index c9ee5a0d85..f2292d9a2c 100644
--- a/src/Sentry/Platforms/Native/buildTransitive/Sentry.Native.targets
+++ b/src/Sentry/Platforms/Native/buildTransitive/Sentry.Native.targets
@@ -8,16 +8,6 @@
   Note:Target framework conditions should be kept synchronized with src/Sentry/buildTransitive/Sentry.Native.targets -->
 <Project>
 
-  <ItemGroup>
-    <!-- When user sets <SentryNative>false</SentryNative> or <SentryNative>disable</SentryNative> in their project -->
-    <!-- SentryNative.IsEnabled should result in compile-time constant for trimmed applications -->
-    <!-- Effectively disabling native library -->
-    <RuntimeHostConfigurationOption Include="Sentry.Native.IsEnabled"
-                                    Condition="'$(SentryNative)' == 'false' or '$(SentryNative)' == 'disable'"
-                                    Value="false"
-                                    Trim="true" />
-  </ItemGroup>
-
   <!-- Helpful properties copied from Sentry.props -->
   <PropertyGroup Condition="'$(TargetFramework)' != ''">
     <_SentryTargetFrameworkVersion>$([MSBuild]::GetTargetFrameworkVersion($(TargetFramework)))</_SentryTargetFrameworkVersion>
@@ -26,12 +16,29 @@
   </PropertyGroup>
 
   <PropertyGroup>
+    <!-- Windows -->
+    <FrameworkSupportsNative Condition="'$(RuntimeIdentifier)' == 'win-x64' or '$(RuntimeIdentifier)' == 'win-arm64'">true</FrameworkSupportsNative>
+    <!-- Linux -->
+    <FrameworkSupportsNative Condition="'$(RuntimeIdentifier)' == 'linux-x64' or '$(RuntimeIdentifier)' == 'linux-arm64' or '$(RuntimeIdentifier)' == 'linux-musl-x64'">true</FrameworkSupportsNative>
+    <!-- macOS -->
+    <FrameworkSupportsNative Condition="'$(RuntimeIdentifier)' == 'osx-x64' or '$(RuntimeIdentifier)' == 'osx-arm64'">true</FrameworkSupportsNative>
     <!-- net8.0 or greater -->
-    <FrameworkSupportsNative Condition="'$(_SentryIsNet8OrGreater)' == 'true' and ('$(OutputType)' == 'Exe' or '$(OutputType)' == 'WinExe')">true</FrameworkSupportsNative>
-    <!-- Make it opt-out -->
+    <FrameworkSupportsNative Condition="'$(_SentryIsNet8OrGreater)' != 'true' or !('$(OutputType)' == 'Exe' or '$(OutputType)' == 'WinExe')">false</FrameworkSupportsNative>
+    <!-- Make it opt-in/out -->
+    <FrameworkSupportsNative Condition="'$(SentryNative)' == 'true' or '$(SentryNative)' == 'enable'">true</FrameworkSupportsNative>
     <FrameworkSupportsNative Condition="'$(SentryNative)' == 'false' or '$(SentryNative)' == 'disable'">false</FrameworkSupportsNative>
   </PropertyGroup>
 
+  <ItemGroup>
+    <!-- When user sets <SentryNative>false</SentryNative> or <SentryNative>disable</SentryNative> in their project -->
+    <!-- SentryNative.IsEnabled should result in compile-time constant for trimmed applications -->
+    <!-- Effectively disabling native library -->
+    <RuntimeHostConfigurationOption Include="Sentry.Native.IsEnabled"
+                                    Condition="'$(FrameworkSupportsNative)' == 'true'"
+                                    Value="true"
+                                    Trim="true" />
+  </ItemGroup>
+
   <ItemGroup Condition="'$(FrameworkSupportsNative)' == 'true' and ('$(RuntimeIdentifier)' == 'win-x64' or '$(RuntimeIdentifier)' == 'win-arm64')">
     <DirectPInvoke Include="sentry-native" />
     <NativeLibrary Include="$(MSBuildThisFileDirectory)..\sentry-native\$(RuntimeIdentifier)\sentry-native.lib" />