diff --git a/CommonLib/Config/GREYConfigKey.h b/CommonLib/Config/GREYConfigKey.h
index d2bede599..982e96be2 100644
--- a/CommonLib/Config/GREYConfigKey.h
+++ b/CommonLib/Config/GREYConfigKey.h
@@ -185,4 +185,13 @@ GREY_EXTERN GREYConfigKey const kGREYConfigKeyAutoUntrackMDCActivityIndicators;
  */
 GREY_EXTERN GREYConfigKey const kGREYConfigKeyAutoHideScrollViewIndicators;
 
+/**
+ * Configuration that holds a list of regular expressions for bundle identifiers
+ * that should not be configured for EarlGrey (e.g. system apps). EarlGrey will
+ * skip injecting eDO arguments and resetting the host port for these apps.
+ *
+ * Accepted values: @c NSArray of valid regular expressions as @c NSString.
+ */
+GREY_EXTERN GREYConfigKey const kGREYConfigKeyBundleIDsExcludedFromSetup;
+
 NS_ASSUME_NONNULL_END
diff --git a/CommonLib/Config/GREYConfigKey.m b/CommonLib/Config/GREYConfigKey.m
index d229210ba..e1dac7970 100644
--- a/CommonLib/Config/GREYConfigKey.m
+++ b/CommonLib/Config/GREYConfigKey.m
@@ -40,3 +40,5 @@
     @"kGREYConfigKeyAutoUntrackMDCActivityIndicators";
 GREYConfigKey const kGREYConfigKeyAutoHideScrollViewIndicators =
     @"GREYConfigKeyAutoHideScrollViewIndicators";
+GREYConfigKey const kGREYConfigKeyBundleIDsExcludedFromSetup =
+    @"GREYConfigKeyBundleIDsExcludedFromSetup";
diff --git a/TestLib/AppleInternals/GREYXCTestAppleInternals.h b/TestLib/AppleInternals/GREYXCTestAppleInternals.h
index 1673d0f8d..b0dbca328 100644
--- a/TestLib/AppleInternals/GREYXCTestAppleInternals.h
+++ b/TestLib/AppleInternals/GREYXCTestAppleInternals.h
@@ -59,3 +59,20 @@
 + (nullable id)sharedClient;
 
 @end
+
+/**
+ * XCTest class representing the active test run's configuration.
+ */
+@interface XCTestConfiguration : NSObject <NSSecureCoding, NSCopying>
+
+/**
+ * Returns the singleton active test configuration instance.
+ */
++ (nonnull instancetype)activeTestConfiguration;
+
+/**
+ * The bundle identifier of the primary application under test.
+ */
+@property(copy, nullable) NSString *targetApplicationBundleID;
+
+@end
diff --git a/TestLib/Config/GREYTestConfiguration.m b/TestLib/Config/GREYTestConfiguration.m
index 2396b06d0..3d1dab68f 100644
--- a/TestLib/Config/GREYTestConfiguration.m
+++ b/TestLib/Config/GREYTestConfiguration.m
@@ -69,6 +69,10 @@ - (instancetype)init {
     [self setDefaultValue:@(kGREYAppLaunchTimeout) forConfigKey:kGREYConfigKeyAppLaunchTimeout];
     [self setDefaultValue:@NO forConfigKey:kGREYConfigKeyAutoUntrackMDCActivityIndicators];
     [self setDefaultValue:@NO forConfigKey:kGREYConfigKeyAutoHideScrollViewIndicators];
+    [self setDefaultValue:@[
+      @"^com\\.apple\\..*",
+    ]
+             forConfigKey:kGREYConfigKeyBundleIDsExcludedFromSetup];
   }
   return self;
 }
diff --git a/TestLib/EarlGreyImpl/XCUIApplication+GREYTest.m b/TestLib/EarlGreyImpl/XCUIApplication+GREYTest.m
index 4c527a65d..e09b369b4 100644
--- a/TestLib/EarlGreyImpl/XCUIApplication+GREYTest.m
+++ b/TestLib/EarlGreyImpl/XCUIApplication+GREYTest.m
@@ -27,6 +27,7 @@
 #import "GREYLogger.h"
 #import "GREYSetup.h"
 #import "GREYSwizzler.h"
+#import "GREYXCTestAppleInternals.h"
 #import "GREYTestConfiguration.h"
 #import "XCUIApplication+GREYEnvironment.h"
 
@@ -52,6 +53,55 @@ + (NSString *)greyTestRigName {
 - (void)grey_launch {
   [self modifyKeyboardSettings];
 
+  static NSString *gPrimaryAppBundleID;
+  static dispatch_once_t onceToken;
+  dispatch_once(&onceToken, ^{
+    @try {
+      gPrimaryAppBundleID = XCTestConfiguration.activeTestConfiguration.targetApplicationBundleID;
+    } @catch (NSException *exception) {
+      GREYLog(@"Failed to read targetApplicationBundleID from XCTestConfiguration: %@", exception);
+    }
+  });
+
+  // It is the primary app under test if the bundleID matches the static target,
+  // or if it is nil/empty (representing the default init rig target).
+  NSString *currentBundleID = self.bundleID;
+  BOOL isPrimaryApp = (gPrimaryAppBundleID.length == 0) || (currentBundleID.length == 0) ||
+                      [gPrimaryAppBundleID isEqualToString:currentBundleID];
+
+  NSArray<NSString *> *excludedRegexes =
+      GREY_CONFIG_ARRAY(kGREYConfigKeyBundleIDsExcludedFromSetup);
+  BOOL isExcluded = NO;
+  if (currentBundleID.length > 0) {
+    NSError *error;
+    for (NSString *regexStr in excludedRegexes) {
+      NSRegularExpression *regex = [NSRegularExpression regularExpressionWithPattern:regexStr
+                                                                             options:0
+                                                                               error:&error];
+      GREYFatalAssertWithMessage(!error, @"Invalid regex:\"%@\". See error: %@", regexStr, error);
+      NSRange firstMatch =
+          [regex rangeOfFirstMatchInString:currentBundleID
+                                   options:0
+                                     range:NSMakeRange(0, [currentBundleID length])];
+      if (firstMatch.location != NSNotFound) {
+        isExcluded = YES;
+        break;
+      }
+    }
+  }
+
+  if (isExcluded) {
+    GREYLog(@"Launching excluded application: %@. Skipping EarlGrey setup.", currentBundleID);
+    INVOKE_ORIGINAL_IMP(void, @selector(grey_launch));
+    return;
+  }
+
+  if (!isPrimaryApp) {
+    GREYLog(@"WARNING: Launching application: %@. Ensure it links EarlGrey "
+            @"AppFramework.",
+            currentBundleID);
+  }
+
   // Setup the Launch Environments.
   [self grey_configureApplicationForLaunch];
   // Setup the Launch Arguments for eDO.
@@ -80,8 +130,8 @@ - (void)grey_launch {
   NSTimer *validTimer = AddTimerForLaunchTimeout();
   INVOKE_ORIGINAL_IMP(void, @selector(grey_launch));
   [validTimer invalidate];
-  // When the identifier is @c nil or empty, it is the TestRig application being launched.
-  if (self.identifier.length == 0) {
+
+  if (isPrimaryApp) {
     objc_setAssociatedObject([XCUIApplication class], @selector(greyTestRigName), self.label,
                              OBJC_ASSOCIATION_RETAIN_NONATOMIC);
   }