diff --git a/.github/.OwlBot.lock.yaml b/.github/.OwlBot.lock.yaml
index c631e1f7d..efe09f2a3 100644
--- a/.github/.OwlBot.lock.yaml
+++ b/.github/.OwlBot.lock.yaml
@@ -13,5 +13,5 @@
 # limitations under the License.
 docker:
   image: gcr.io/cloud-devrel-public-resources/owlbot-python:latest
-  digest: sha256:5581906b957284864632cde4e9c51d1cc66b0094990b27e689132fe5cd036046
-# created: 2025-03-05
+  digest: sha256:21c50ac6b72047705ceac7b3c84dca11f771f40b5cdfd8931bf1f446a89274e5
+# created: 2025-04-14T15:05:23.836138399Z
diff --git a/noxfile.py b/noxfile.py
index dd182f105..6b8ebe318 100644
--- a/noxfile.py
+++ b/noxfile.py
@@ -34,6 +34,8 @@
 
 MYPY_VERSION = "mypy==1.10.0"
 
+MYPY_VERSION = "mypy==1.10.0"
+
 DEFAULT_PYTHON_VERSION = "3.8"
 
 UNIT_TEST_PYTHON_VERSIONS: List[str] = [
@@ -87,6 +89,11 @@
     "mypy",
     # https://github.com/googleapis/python-pubsub/pull/552#issuecomment-1016256936
     # "mypy_samples",  # TODO: uncomment when the check passes
+    "mypy",
+    # https://github.com/googleapis/python-pubsub/pull/552#issuecomment-1016256936
+    # "mypy_samples",  # TODO: uncomment when the check passes
+    # https://github.com/googleapis/python-pubsub/pull/552#issuecomment-1016256936
+    # "mypy_samples",  # TODO: uncomment when the check passes
     "docs",
     "docfx",
     "format",
@@ -143,6 +150,77 @@ def mypy_samples(session):
     )
 
 
+@nox.session(python=DEFAULT_PYTHON_VERSION)
+def mypy(session):
+    """Run type checks with mypy."""
+    session.install("-e", ".[all]")
+    session.install(MYPY_VERSION)
+
+    # Version 2.1.1 of google-api-core version is the first type-checked release.
+    # Version 2.2.0 of google-cloud-core version is the first type-checked release.
+    session.install(
+        "google-api-core[grpc]>=2.1.1",
+        "google-cloud-core>=2.2.0",
+    )
+
+    # Just install the type info directly, since "mypy --install-types" might
+    # require an additional pass.
+    # Exclude types-protobuf==4.24.0.20240106
+    # See https://github.com/python/typeshed/issues/11254
+    session.install("types-protobuf!=4.24.0.20240106", "types-setuptools")
+
+    # TODO: Only check the hand-written layer, the generated code does not pass
+    # mypy checks yet.
+    # https://github.com/googleapis/gapic-generator-python/issues/1092
+    session.run("mypy", "-p", "google.cloud")
+
+
+@nox.session(python=DEFAULT_PYTHON_VERSION)
+def mypy_samples(session):
+    """Run type checks with mypy."""
+
+    session.install("-e", ".[all]")
+
+    session.install("pytest")
+    session.install(MYPY_VERSION)
+
+    # Just install the type info directly, since "mypy --install-types" might
+    # require an additional pass.
+    session.install("types-mock", "types-protobuf", "types-setuptools")
+
+    session.run(
+        "mypy",
+        "--config-file",
+        str(CURRENT_DIRECTORY / "samples" / "snippets" / "mypy.ini"),
+        "--no-incremental",  # Required by warn-unused-configs from mypy.ini to work
+        "samples/",
+    )
+
+
+@nox.session(python=DEFAULT_PYTHON_VERSION)
+def mypy_samples(session):
+    """Run type checks with mypy."""
+
+    session.install("-e", ".[all]")
+
+    session.install("pytest")
+    session.install(MYPY_VERSION)
+
+    # Just install the type info directly, since "mypy --install-types" might
+    # require an additional pass.
+    session.install("types-mock", "types-protobuf", "types-setuptools")
+
+    session.run(
+        "mypy",
+        # https://github.com/googleapis/python-pubsub/pull/552#issuecomment-1016256936
+        # "mypy_samples",  # TODO: uncomment when the check passes
+        "--config-file",
+        str(CURRENT_DIRECTORY / "samples" / "snippets" / "mypy.ini"),
+        "--no-incremental",  # Required by warn-unused-configs from mypy.ini to work
+        "samples/",
+    )
+
+
 @nox.session(python=DEFAULT_PYTHON_VERSION)
 def lint(session):
     """Run linters.
@@ -251,7 +329,7 @@ def unit(session, protobuf_implementation):
         "py.test",
         "--quiet",
         f"--junitxml=unit_{session.python}_sponge_log.xml",
-        "--cov=google/cloud",
+        "--cov=google/cloud/cloud",
         "--cov=tests/unit",
         "--cov-append",
         "--cov-config=.coveragerc",