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***H*****igh *A*mbiguity *D*riven biomolecular DOCKing
based on biochemical and/or biophysical information.
Version: 2.5 (March 2026) (changes)
Authors: Alexandre Bonvin and members of the computational structural biology group, Utrecht University
Contact:
Bijvoet Center for Biomolecular Research
Padualaan 8, 3584 CH Utrecht, the Netherlands
Email: a.m.j.j.bonvin@uu.nl
Phone: +31-30-2533859
Fax: +31-30-2537623
HADDOCK is one of the flagship software in the EU H2020 BioExcel Center of Excellence for Biomolecular Research
Note that as of December 2024 we are only distributing the 2.5 version of HADDOCK, which is the Python3 port of HADDOCK2.4. The functionalities are the same as the 2.4 version (the online manual has not changed). The web server is still called HADDOCK2.4, but run in backgroun the 2.5 version.
HADDOCK2.4/5 manual: https://www.bonvinlab.org/software/haddock2.4/manual
HADDOCK2.4 webserver: https://wenmr.science.uu.nl/haddock2.4
Getting the software: license form
Questions about HADDOCK or looking for support? Ask BioExcel
HADDOCK best practice guide - A must read when starting to use our software!
An introduction to HADDOCK2.4/5: View the SBGrid [webinar]:
View recorded lecture
<iframe width="560" height="315" src="https://www.youtube.com/embed/PDfFOUqdt5I" title="YouTube video player" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture" allowfullscreen></iframe>(https://www.youtube.com/watch?v=PDfFOUqdt5I) (June 29th, 2021).
Two lectures about integrative modelling and HADDOCK: Recording of a lecture by Prof. Bonvin at the 2021 BioExcel summerschool:
View recorded lecture Part I (46 min.)
<iframe width="560" height="315" src="https://www.youtube.com/embed/N2Sr4qtRKhs" title="YouTube video player" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture" allowfullscreen></iframe>View recorded lecture Part II (43 min.)
<iframe width="560" height="315" src="https://www.youtube.com/embed/qpx6bQZhWrU" title="YouTube video player" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture" allowfullscreen></iframe>When using HADDOCK cite:
- Cyril Dominguez, Rolf Boelens and Alexandre M.J.J. Bonvin. HADDOCK: a protein-protein docking approach based on biochemical and/or biophysical information. J. Am. Chem. Soc. 125, 1731-1737 (2003).
{% include paper_citation.html key="haddock24" %}
For additional citations when using specific modules see also our publication page.
HADDOCK was originally derived from ARIA scripts by Michael Nilges and Jens Linge.
- J.P. Linge, M. Habeck, W. Rieping and M. Nilges (2003). ARIA: automated NOE assignment and NMR structure calculation. Bioinformatics 19, 315-316.
The ongoing development of HADDOCK is the result of a team effort and in particular contributions from Cyril Dominguez, Aalt-Jan van Dijk, Sjoerd de Vries, Marc van Dijk, Ezgi Karaca, Panagiotis Kastritis, Adrien Melquiond, Mikael Trellet, Gydo van Zundert and Joao Rodrigues are acknowledged.
... more than fish or software..., discover the "capitaine" ... 
Copyright © Hergé Moulinsart 2003