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Copy file name to clipboardExpand all lines: education/HADDOCK24/RNA-Pol-III-2024/index.md
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@@ -745,7 +745,7 @@ in the map and calculate a cross-correlation score for each of them.
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PowerFit is open-source and available for download from our [Github repository][link-powerfit]{:target="_blank"}.
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To facilitate its use, we have developed a [web portal][link-powerfit-web]{:target="_blank"} for it.
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The server makes use of either local resources on our cluster, using the multi-core version of the software, or GPGPU-accelerated grid resources of the
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The server makes use of either local resources on our cluster, using the multi-core version of the software, or GPU-accelerated grid resources of the
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[EGI](https://www.egi.eu){:target="_blank"} to speed up the calculations. It only requires a web browser to work and benefits from the latest
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developments in the software, based on a stable and tested workflow. Next to providing an automated workflow around
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PowerFit, the web server also summarizes and higlights the results in a single page including some additional postprocessing
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### Setting up the full docking run using the cryo-EM fitted and refined core and C82 domains
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We will setup a docking run to model the full complex including some information about the C31 cross-links and the missing two first wHTH domains of C34. For this we will use the PowerFit/Chimera, HADDOCK-refined structure (Core+C82+C34wHTH3) which we have generated as starting point. We will fix those domains in their original positions for the initial rigid-body docking stage and dock the two missing C34 wHTH domains including fragments of C31 for which we have cross-links.
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We will setup a docking run to model the full complex including some information about the C31 cross-links and the missing two first wHTH domains of C34. For this we will use the PowerFit/ChimeraX, HADDOCK-refined structure (Core+C82+C34wHTH3) which we have generated as starting point. We will fix those domains in their original positions for the initial rigid-body docking stage and dock the two missing C34 wHTH domains including fragments of C31 for which we have cross-links.
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Connect to the [HADDOCK2.4 interface](https://wenmr.science.uu.nl/haddock2.4/submit/1){:target="_blank"} of the HADDOCK web server.
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