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The model is implemented in Stan and uses a logistic regression approximation to estimate conditional intensity functions efficiently, even for large high-resolution datasets.
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For more technical details and case studies, please see [our preprint](https://doi.org/10.1101/2025.06.24.661393) and [our repo](https://github.com/jeliason/shade_paper_code) for reproducing analyses and figures from that manuscript.
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For more technical details and case studies, please see [our paper in PLOS Computational Biology](https://doi.org/10.1371/journal.pcbi.1013930) and [our repo](https://github.com/jeliason/shade_paper_code) for reproducing analyses and figures from that manuscript.
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## Installation
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## Citation and References
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If you use SHADE in your work, please cite the accompanying [preprint](https://doi.org/10.1101/2025.06.24.661393):
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If you use SHADE in your work, please cite the accompanying [paper](https://doi.org/10.1371/journal.pcbi.1013930):
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```bibtex
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@misc{
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title = {{{SHADE}}: {{A Multilevel Bayesian Approach}} to {{Modeling Directional Spatial Associations}} in {{Tissues}}},
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@article{eliason2026shade,
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title = {{SHADE}: A multilevel {Bayesian} framework for modeling directional spatial interactions in tissue microenvironments},
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author = {Eliason, Joel and Peruzzi, Michele and Rao, Arvind},
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