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Add biosynthetic gene cluster (BGC) categories value set
Add a new schema module defining BGC categories for natural product biosynthesis: - POLYKETIDE (CHEBI:26188) - NRP (Non-ribosomal peptide) - RIPP (Ribosomally synthesized and post-translationally modified peptide) - TERPENE (CHEBI:35186) - ALKALOID (CHEBI:22315) - SACCHARIDE (CHEBI:18154) - OTHER Categories based on MIBiG standard for biosynthetic gene cluster classification.
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name: bgc_categories
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title: Biosynthetic Gene Cluster Categories
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description: 'Value sets for biosynthetic gene cluster (BGC) categories used in natural
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product biosynthesis.
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These categories represent the major classes of secondary metabolites produced by
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BGCs.
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Based on the MIBiG (Minimum Information about a Biosynthetic Gene cluster) standard.'
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id: https://w3id.org/linkml/valuesets/bio/bgc_categories
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imports:
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- linkml:types
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prefixes:
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linkml: https://w3id.org/linkml/
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valuesets: https://w3id.org/valuesets/
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CHEBI: http://purl.obolibrary.org/obo/CHEBI_
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orcid: https://orcid.org/
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valuesets_meta: https://w3id.org/valuesets/meta/
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default_prefix: valuesets
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slots:
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bgc_category:
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description: Biosynthetic gene cluster category
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range: BgcCategoryEnum
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enums:
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BgcCategoryEnum:
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title: BGC Category
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description: 'Categories of biosynthetic gene clusters based on the type of secondary
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metabolite produced.
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These categories are used in genome mining and natural product discovery.'
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status: DRAFT
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contributors:
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- orcid:0000-0002-6601-2165
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- https://github.com/anthropics/claude-code
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instantiates:
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- valuesets_meta:ValueSetEnumDefinition
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permissible_values:
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POLYKETIDE:
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description: Polyketide biosynthetic gene clusters
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meaning: CHEBI:26188
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annotations:
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definition: Natural products containing alternating carbonyl and methylene
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groups
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biosynthetic_enzyme: Polyketide synthase (PKS)
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examples: Erythromycin, lovastatin, rapamycin
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NRP:
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title: Non-ribosomal peptide
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description: Non-ribosomal peptide biosynthetic gene clusters
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annotations:
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definition: Peptides synthesized by non-ribosomal peptide synthetases
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biosynthetic_enzyme: Non-ribosomal peptide synthetase (NRPS)
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examples: Penicillin, vancomycin, cyclosporin
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RIPP:
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title: Ribosomally synthesized and post-translationally modified peptide
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description: RiPP biosynthetic gene clusters
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annotations:
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definition: Ribosomally synthesized peptides with extensive post-translational
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modifications
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biosynthetic_enzyme: Various modifying enzymes
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examples: Nisin, thiopeptides, lanthipeptides
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related_chebi: CHEBI:71629 (nisin)
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TERPENE:
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description: Terpene biosynthetic gene clusters
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meaning: CHEBI:35186
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annotations:
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definition: Hydrocarbons derived from isoprene units
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biosynthetic_enzyme: Terpene synthase
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examples: Limonene, carotenoids, taxol
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ALKALOID:
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description: Alkaloid biosynthetic gene clusters
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meaning: CHEBI:22315
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annotations:
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definition: Nitrogen-containing organic compounds with diverse structures
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biosynthetic_enzyme: Various enzymes
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examples: Morphine, caffeine, nicotine
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SACCHARIDE:
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description: Saccharide/polysaccharide biosynthetic gene clusters
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meaning: CHEBI:18154
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annotations:
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definition: Carbohydrate polymers and oligomers
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biosynthetic_enzyme: Glycosyltransferases
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examples: Cellulose, chitin, bacterial capsular polysaccharides
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OTHER:
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description: Other or unclassified biosynthetic gene clusters
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annotations:
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definition: BGCs that do not fit into standard categories or are of unknown
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type
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examples: Novel or hybrid BGCs

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