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@@ -9,6 +9,7 @@ Initial release of nf-core/proteinannotator, created with the [nf-core](https://
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### `Added`
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-[#67](https://github.com/nf-core/proteinannotator/pull/67) - Swapped to the updated, non-buggy, nf-core version of `INTERPROSCAN`. (by @vagkaratzas)
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-[#65](https://github.com/nf-core/proteinannotator/pull/65) - Converted the pipeline schematic to nf-core metromap. (by @vagkaratzas)
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-[#62](https://github.com/nf-core/proteinannotator/pull/62) - Added the option to download and use the latest FunFam HMM library (or use path to an existing one) for domain annotation. (by @vagkaratzas)
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-[#61](https://github.com/nf-core/proteinannotator/pull/61) - Added nf-core modules `ARIA2` and `HMMER_HMMSEARCH` to download latest Pfam HMM library (or use path to existing one) and match domains to input sequences. (by @vagkaratzas)
-`<samplename>.xml`: eXtensible markup language (XML) file
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</details>
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[InterProScan](https://interproscan-docs.readthedocs.io/en/v5/#) is a protein annotation tool that searches [InterPro](http://www.ebi.ac.uk/interpro/), a database which integrates together predictive information about proteins’ function from a number of partner resources, giving an overview of the families that a protein belongs to and the domains and sites it contains.
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[InterProScan](https://interproscan-docs.readthedocs.io/en/v5/#) is a protein annotation tool that searches [InterPro](http://www.ebi.ac.uk/interpro/), a database which integrates predictive information about protein function from a number of member resources, giving an overview of the families that a protein belongs to and the domains and sites it contains.
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For `nf-core/proteinannotator`, the default database applications that are used to functionally annotate sequences include
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Hamap, PANTHER, PIRSF, TIGRFAM and sfld. The main `nextflow.config` contains a [url]("https://ftp.ebi.ac.uk/pub/software/unix/iprscan/5/5.72-103.0/interproscan-5.72-103.0-64-bit.tar.gz") parameter (`--interproscan_db_url`) for the full version of the InterProScan database, whereas the test profiles override that with a minimal test version of the database. If, instead, a local database is provided via the `--interproscan_db` parameter, then the download is skipped.
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See also [InterProScan output documentation](https://interproscan-docs.readthedocs.io/en/v5/), where most of these examples are taken from.
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