diff --git a/pylib/gyp/common.py b/pylib/gyp/common.py
index fbf1024f..35a64b1e 100644
--- a/pylib/gyp/common.py
+++ b/pylib/gyp/common.py
@@ -421,8 +421,9 @@ def EnsureDirExists(path):
     except OSError:
         pass
 
-def GetCrossCompilerPredefines():  # -> dict
+def GetCompilerPredefines():  # -> dict
     cmd = []
+    defines = {}
 
     # shlex.split() will eat '\' in posix mode, but
     # setting posix=False will preserve extra '"' cause CreateProcess fail on Windows
@@ -439,7 +440,7 @@ def replace_sep(s):
         if CXXFLAGS := os.environ.get("CXXFLAGS"):
             cmd += shlex.split(replace_sep(CXXFLAGS))
     else:
-        return {}
+        return defines
 
     if sys.platform == "win32":
         fd, input = tempfile.mkstemp(suffix=".c")
@@ -450,17 +451,33 @@ def replace_sep(s):
                 real_cmd, shell=True,
                 capture_output=True, check=True
             ).stdout
+        except subprocess.CalledProcessError as e:
+            print(
+                "Warning: failed to get compiler predefines\n"
+                "cmd: %s\n"
+                "status: %d" % (e.cmd, e.returncode),
+                file=sys.stderr
+            )
+            return defines
         finally:
             os.unlink(input)
     else:
         input = "/dev/null"
         real_cmd = [*cmd, "-dM", "-E", "-x", "c", input]
-        stdout = subprocess.run(
-            real_cmd, shell=False,
-            capture_output=True, check=True
-        ).stdout
+        try:
+            stdout = subprocess.run(
+                real_cmd, shell=False,
+                capture_output=True, check=True
+            ).stdout
+        except subprocess.CalledProcessError as e:
+            print(
+                "Warning: failed to get compiler predefines\n"
+                "cmd: %s\n"
+                "status: %d" % (e.cmd, e.returncode),
+                file=sys.stderr
+            )
+            return defines
 
-    defines = {}
     lines = stdout.decode("utf-8").replace("\r\n", "\n").split("\n")
     for line in lines:
         if (line or "").startswith("#define "):
@@ -499,7 +516,7 @@ def GetFlavor(params):
     if "flavor" in params:
         return params["flavor"]
 
-    defines = GetCrossCompilerPredefines()
+    defines = GetCompilerPredefines()
     if "__EMSCRIPTEN__" in defines:
         return "emscripten"
     if "__wasm__" in defines:
diff --git a/pylib/gyp/common_test.py b/pylib/gyp/common_test.py
index bd7172af..d25e621a 100755
--- a/pylib/gyp/common_test.py
+++ b/pylib/gyp/common_test.py
@@ -7,6 +7,7 @@
 """Unit tests for the common.py file."""
 
 import os
+import subprocess
 import sys
 import unittest
 from unittest.mock import MagicMock, patch
@@ -85,22 +86,34 @@ def decode(self, encoding):
     @patch("os.close")
     @patch("os.unlink")
     @patch("tempfile.mkstemp")
-    def test_GetCrossCompilerPredefines(self, mock_mkstemp, mock_unlink, mock_close):
+    def test_GetCompilerPredefines(self, mock_mkstemp, mock_unlink, mock_close):
         mock_close.return_value = None
         mock_unlink.return_value = None
         mock_mkstemp.return_value = (0, "temp.c")
 
-        def mock_run(env, defines_stdout, expected_cmd):
+        def mock_run(env, defines_stdout, expected_cmd, throws=False):
             with patch("subprocess.run") as mock_run:
-                mock_process = MagicMock()
-                mock_process.returncode = 0
-                mock_process.stdout = TestGetFlavor.MockCommunicate(defines_stdout)
-                mock_run.return_value = mock_process
                 expected_input = "temp.c" if sys.platform == "win32" else "/dev/null"
+                if throws:
+                    mock_run.side_effect = subprocess.CalledProcessError(
+                        returncode=1,
+                        cmd=[
+                            *expected_cmd,
+                            "-dM", "-E", "-x", "c", expected_input
+                        ]
+                    )
+                else:
+                    mock_process = MagicMock()
+                    mock_process.returncode = 0
+                    mock_process.stdout = TestGetFlavor.MockCommunicate(defines_stdout)
+                    mock_run.return_value = mock_process
                 with patch.dict(os.environ, env):
-                    defines = gyp.common.GetCrossCompilerPredefines()
+                    try:
+                        defines = gyp.common.GetCompilerPredefines()
+                    except Exception as e:
+                        self.fail(f"GetCompilerPredefines raised an exception: {e}")
                     flavor = gyp.common.GetFlavor({})
-                if env.get("CC_target"):
+                if env.get("CC_target") or env.get("CC"):
                     mock_run.assert_called_with(
                         [
                             *expected_cmd,
@@ -110,6 +123,9 @@ def mock_run(env, defines_stdout, expected_cmd):
                         capture_output=True, check=True)
                 return [defines, flavor]
 
+        [defines0, _] = mock_run({ "CC": "cl.exe" }, "", ["cl.exe"], True)
+        assert defines0 == {}
+
         [defines1, _] = mock_run({}, "", [])
         assert defines1 == {}