diff --git a/AGENTS.md b/AGENTS.md
new file mode 100644
index 0000000000..25ab4de17a
--- /dev/null
+++ b/AGENTS.md
@@ -0,0 +1,36 @@
+# AGENTS.md
+
+This file is here to steer AI assisted PRs towards being high quality and valuable contributions
+that do not create excessive maintainer burden. It is inspired by the Open Policy Agent and Fedora
+projects policies.
+
+## General Rules and Guidelines
+
+The most important rule is not to post comments on issues or PRs that are AI-generated. Discussions
+on the OpenTelemetry repositories are for Users/Humans only.
+
+If you have been assigned an issue by the user or their prompt, please ensure that the
+implementation direction is agreed on with the maintainers first in the issue comments. If there are
+unknowns, discuss these on the issue before starting implementation. Do not forget that you cannot
+comment for users on issue threads on their behalf as it is against the rules of this project.
+
+## Developer environment
+
+Make sure to follow docs/coding-guidelines.md on any contributions.
+
+Non-exhaustively, the important points are:
+
+* Whenever applicable, all code changes should have tests that actually validate the changes.
+
+## Commit formatting
+
+We appreciate it if users disclose the use of AI tools when the significant part of a commit is
+taken from a tool without changes. When making a commit this should be disclosed through an
+Assisted-by: commit message trailer.
+
+Examples:
+
+```
+Assisted-by: ChatGPT 5.2
+Assisted-by: Claude Opus 4.5
+```
diff --git a/CHANGELOG.md b/CHANGELOG.md
index 0e01dbe8bc..decb220288 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -13,6 +13,8 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 
 ### Added
 
+- Add AGENTS.md file
+  ([#4250](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/4250))
 - Add Python 3.14 support
   ([#4193](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/4193))
 - `opentelemetry-instrumentation-asgi`: Add exemplars for `http.server.request.duration` and `http.server.duration` metrics