diff --git a/CHANGELOG.md b/CHANGELOG.md
index 2c4d7ebddd..2e2eea8927 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -28,6 +28,8 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
   ([#4321](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/4321))
 - `opentelemetry-instrumentation-logging`: Add recursion guard in LoggingHandler.emit to prevent deadlock
   ([#4302](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/4302))
+- `opentelemetry-instrumentation-grpc`: Fix bidirectional streaming RPCs raising `AttributeError: 'generator' object has no attribute 'add_done_callback'`
+  ([#4259](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/4259))
 
 ### Breaking changes
 
diff --git a/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/_client.py b/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/_client.py
index bbeb4ec1d9..a9264b56f4 100644
--- a/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/_client.py
+++ b/instrumentation/opentelemetry-instrumentation-grpc/src/opentelemetry/instrumentation/grpc/_client.py
@@ -60,6 +60,12 @@ def callback(response_future):
             code = response_future.code()
             if code != grpc.StatusCode.OK:
                 rpc_info.error = code
+                span.set_attribute(RPC_GRPC_STATUS_CODE, code.value[0])
+                span.set_status(
+                    Status(
+                        status_code=StatusCode.ERROR,
+                    )
+                )
                 return
             response = response_future.result()
             rpc_info.response = response
@@ -228,7 +234,7 @@ def intercept_stream(
         if self._filter is not None and not self._filter(client_info):
             return invoker(request_or_iterator, metadata)
 
-        if client_info.is_server_stream:
+        if client_info.is_server_stream and not client_info.is_client_stream:
             return self._intercept_server_stream(
                 request_or_iterator, metadata, client_info, invoker
             )
diff --git a/instrumentation/opentelemetry-instrumentation-grpc/tests/test_aio_client_interceptor.py b/instrumentation/opentelemetry-instrumentation-grpc/tests/test_aio_client_interceptor.py
index 850ad79661..daa4d68dc3 100644
--- a/instrumentation/opentelemetry-instrumentation-grpc/tests/test_aio_client_interceptor.py
+++ b/instrumentation/opentelemetry-instrumentation-grpc/tests/test_aio_client_interceptor.py
@@ -224,6 +224,10 @@ async def test_error_simple(self):
             span.status.status_code,
             trace.StatusCode.ERROR,
         )
+        self.assertEqual(
+            span.attributes[RPC_GRPC_STATUS_CODE],
+            grpc.StatusCode.INVALID_ARGUMENT.value[0],
+        )
 
     async def test_error_unary_stream(self):
         with self.assertRaises(grpc.RpcError):
@@ -237,6 +241,10 @@ async def test_error_unary_stream(self):
             span.status.status_code,
             trace.StatusCode.ERROR,
         )
+        self.assertEqual(
+            span.attributes[RPC_GRPC_STATUS_CODE],
+            grpc.StatusCode.INVALID_ARGUMENT.value[0],
+        )
 
     async def test_error_stream_unary(self):
         with self.assertRaises(grpc.RpcError):
@@ -249,6 +257,10 @@ async def test_error_stream_unary(self):
             span.status.status_code,
             trace.StatusCode.ERROR,
         )
+        self.assertEqual(
+            span.attributes[RPC_GRPC_STATUS_CODE],
+            grpc.StatusCode.INVALID_ARGUMENT.value[0],
+        )
 
     async def test_error_stream_stream(self):
         with self.assertRaises(grpc.RpcError):
@@ -264,6 +276,10 @@ async def test_error_stream_stream(self):
             span.status.status_code,
             trace.StatusCode.ERROR,
         )
+        self.assertEqual(
+            span.attributes[RPC_GRPC_STATUS_CODE],
+            grpc.StatusCode.INVALID_ARGUMENT.value[0],
+        )
 
     # pylint:disable=no-self-use
     async def test_client_interceptor_trace_context_propagation(self):
diff --git a/instrumentation/opentelemetry-instrumentation-grpc/tests/test_client_interceptor.py b/instrumentation/opentelemetry-instrumentation-grpc/tests/test_client_interceptor.py
index e001d2ed57..3830bf00c4 100644
--- a/instrumentation/opentelemetry-instrumentation-grpc/tests/test_client_interceptor.py
+++ b/instrumentation/opentelemetry-instrumentation-grpc/tests/test_client_interceptor.py
@@ -221,6 +221,51 @@ def test_stream_stream(self):
             },
         )
 
+    def test_stream_stream_preserves_call_interface(self):
+        """Regression test for issue #1180.
+
+        Bidirectional streaming RPCs must return an object that implements
+        grpc.Call (add_done_callback, cancel, is_active, etc.) rather than
+        a bare generator.  Before the fix, bidi streams were routed through
+        the generator-based _intercept_server_stream, which stripped the
+        grpc.Call interface and caused downstream code to crash with:
+            AttributeError: 'generator' object has no attribute 'add_done_callback'
+        """
+
+        def request_messages():
+            for _ in range(5):
+                yield Request(client_id=1, request_data="data")
+
+        response_iterator = self._stub.BidirectionalStreamingMethod(
+            request_messages(), metadata=(("key", "value"),)
+        )
+
+        for attr in ("add_done_callback", "cancel", "is_active"):
+            self.assertTrue(
+                hasattr(response_iterator, attr),
+                f"bidi stream response missing grpc.Call method '{attr}'",
+            )
+
+        list(response_iterator)
+
+        spans = self.memory_exporter.get_finished_spans()
+        self.assertEqual(len(spans), 1)
+        span = spans[0]
+
+        self.assertEqual(
+            span.name, "/GRPCTestServer/BidirectionalStreamingMethod"
+        )
+        self.assertIs(span.kind, trace.SpanKind.CLIENT)
+        self.assertSpanHasAttributes(
+            span,
+            {
+                RPC_METHOD: "BidirectionalStreamingMethod",
+                RPC_SERVICE: "GRPCTestServer",
+                RPC_SYSTEM: "grpc",
+                RPC_GRPC_STATUS_CODE: grpc.StatusCode.OK.value[0],
+            },
+        )
+
     def test_error_simple(self):
         with self.assertRaises(grpc.RpcError):
             simple_method(self._stub, error=True)
@@ -232,6 +277,10 @@ def test_error_simple(self):
             span.status.status_code,
             trace.StatusCode.ERROR,
         )
+        self.assertEqual(
+            span.attributes[RPC_GRPC_STATUS_CODE],
+            grpc.StatusCode.INVALID_ARGUMENT.value[0],
+        )
 
     def test_error_stream_unary(self):
         with self.assertRaises(grpc.RpcError):
@@ -244,6 +293,10 @@ def test_error_stream_unary(self):
             span.status.status_code,
             trace.StatusCode.ERROR,
         )
+        self.assertEqual(
+            span.attributes[RPC_GRPC_STATUS_CODE],
+            grpc.StatusCode.INVALID_ARGUMENT.value[0],
+        )
 
     def test_error_unary_stream(self):
         with self.assertRaises(grpc.RpcError):
@@ -256,6 +309,10 @@ def test_error_unary_stream(self):
             span.status.status_code,
             trace.StatusCode.ERROR,
         )
+        self.assertEqual(
+            span.attributes[RPC_GRPC_STATUS_CODE],
+            grpc.StatusCode.INVALID_ARGUMENT.value[0],
+        )
 
     def test_error_stream_stream(self):
         with self.assertRaises(grpc.RpcError):
@@ -268,6 +325,10 @@ def test_error_stream_stream(self):
             span.status.status_code,
             trace.StatusCode.ERROR,
         )
+        self.assertEqual(
+            span.attributes[RPC_GRPC_STATUS_CODE],
+            grpc.StatusCode.INVALID_ARGUMENT.value[0],
+        )
 
     def test_client_interceptor_falsy_response(
         self,