diff --git a/CHANGELOG.md b/CHANGELOG.md
index 93f0cab4fc..e56afd1e0c 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -21,7 +21,8 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
   ([#4457](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/4457))
 
 ### Fixed
-
+- `opentelemetry-instrumentation`: Batch all packages into a single `pip install` call in `bootstrap.py` to improve performance
+  ([#4530](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/4530))
 - `opentelemetry-instrumentation-pika` Use `ObjectProxy` instead of `BaseObjectProxy` for `ReadyMessagesDequeProxy` to restore iterability with wrapt 2.x
   ([#4461](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/4461))
 - `opentelemetry-instrumentation-dbapi` Use `ObjectProxy` instead of `BaseObjectProxy` for `TracedCursorProxy` to restore iterability with wrapt 2.x
diff --git a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap.py b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap.py
index 3fbee088e4..e0934b7334 100644
--- a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap.py
+++ b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap.py
@@ -42,38 +42,31 @@
 
 
 def _syscall(func):
-    def wrapper(package=None):
+    def wrapper(packages=None, upgrade=True):
         try:
-            if package:
-                return func(package)
+            if packages:
+                return func(packages, upgrade)
             return func()
         except SubprocessError as exp:
             cmd = getattr(exp, "cmd", None)
             if cmd:
                 msg = f'Error calling system command "{" ".join(cmd)}"'
-            if package:
-                msg = f'{msg} for package "{package}"'
+            if packages:
+                msg = f'{msg} for package "{packages}"'
             raise RuntimeError(msg)
 
     return wrapper
 
 
 @_syscall
-def _sys_pip_install(package):
+def _sys_pip_install(packages, upgrade=True):
     # explicit upgrade strategy to override potential pip config
     try:
-        check_call(
-            [
-                sys.executable,
-                "-m",
-                "pip",
-                "install",
-                "-U",
-                "--upgrade-strategy",
-                "only-if-needed",
-                package,
-            ]
-        )
+        cmd = [sys.executable, "-m", "pip", "install"]
+        if upgrade:
+            cmd += ["-U", "--upgrade-strategy", "only-if-needed"]
+        cmd += [*packages]
+        check_call(cmd)
     except CalledProcessError as error:
         print(error)
 
@@ -133,9 +126,10 @@ def _run_requirements(default_instrumentations, libraries):
     )
 
 
-def _run_install(default_instrumentations, libraries):
-    for lib in _find_installed_libraries(default_instrumentations, libraries):
-        _sys_pip_install(lib)
+def _run_install(default_instrumentations, libraries, upgrade=True):
+    libs = list(_find_installed_libraries(default_instrumentations, libraries))
+    if libs:
+        _sys_pip_install(libs, upgrade=upgrade)
     _pip_check(libraries)
 
 
@@ -170,6 +164,11 @@ def run(
                        be piped and appended to a requirements.txt file.
         """,
     )
+    parser.add_argument(
+        "--no-upgrade",
+        action="store_true",
+        help="Do not upgrade packages with -U flag during install",
+    )
     args = parser.parse_args()
 
     if libraries is None:
@@ -178,8 +177,9 @@ def run(
     if default_instrumentations is None:
         default_instrumentations = gen_default_instrumentations
 
-    cmd = {
-        action_install: _run_install,
-        action_requirements: _run_requirements,
-    }[args.action]
-    cmd(default_instrumentations, libraries)
+    if args.action == action_install:
+        _run_install(
+            default_instrumentations, libraries, upgrade=not args.no_upgrade
+        )
+    else:
+        _run_requirements(default_instrumentations, libraries)