diff --git a/CHANGELOG.md b/CHANGELOG.md
index 1a8d55fb3..5ebbe0cf6 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -8,6 +8,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 ## [Unreleased]
 
 - Add margins to numbered lists in `hs-physics` worked examples and snap labs (CORE-1789)
+- Keep science-practice single-column for tables with 6+ columns
 - Indent question stem lists less in `carnival`
 - Indent first-level lists in eos sections in `corn`
 
diff --git a/styles/books/ap-biology/book.scss b/styles/books/ap-biology/book.scss
index 84532efc8..d678674b7 100644
--- a/styles/books/ap-biology/book.scss
+++ b/styles/books/ap-biology/book.scss
@@ -62,7 +62,7 @@
 
 @include add_settings((
   TwoColumnsModules: (
-    _selectors: ('.os-review-container', '.os-ap-test-prep-container', '.os-science-practice-container'),
+    _selectors: ('.os-review-container', '.os-ap-test-prep-container', '.os-science-practice-container:not(:has(.os-table > table tr td:nth-of-type(6)))'),
   ),
 ));
 
diff --git a/styles/output/ap-biology-pdf.css b/styles/output/ap-biology-pdf.css
index 7f4ee974e..ae517c074 100644
--- a/styles/output/ap-biology-pdf.css
+++ b/styles/output/ap-biology-pdf.css
@@ -3863,7 +3863,7 @@ h4.os-subtitle + .os-figure:not(.has-splash) > figure {
   column-width: auto;
 }
 
-.os-science-practice-container {
+.os-science-practice-container:not(:has(.os-table > table tr td:nth-of-type(6))) {
   column-count: 2;
   column-gap: 2.4rem;
   column-width: auto;