diff --git a/CHANGES.rst b/CHANGES.rst
index a5fa63f14e..e3cd0d9968 100644
--- a/CHANGES.rst
+++ b/CHANGES.rst
@@ -3,6 +3,8 @@ Version 3.2.0
 
 Unreleased
 
+-   Optimize request dispatching by caching the result of ``ensure_sync`` for view
+    functions in ``_sync_view_functions``, reducing CPU overhead. :pr:`5939`
 -   Drop support for Python 3.9. :pr:`5730`
 -   Remove previously deprecated code: ``__version__``. :pr:`5648`
 -   ``RequestContext`` has merged with ``AppContext``. ``RequestContext`` is now
diff --git a/docs/async-await.rst b/docs/async-await.rst
index bb3338029a..ddba602356 100644
--- a/docs/async-await.rst
+++ b/docs/async-await.rst
@@ -107,6 +107,10 @@ the decorated function,
 
         return wrapper
 
+To improve performance, consider caching the result of ``ensure_sync`` if your
+extension calls it frequently on the same function. This is how Flask internally
+optimizes request dispatching.
+
 Check the changelog of the extension you want to use to see if they've
 implemented async support, or make a feature request or PR to them.
 
diff --git a/src/flask/app.py b/src/flask/app.py
index 652b9bbf71..04e6e1a3aa 100644
--- a/src/flask/app.py
+++ b/src/flask/app.py
@@ -333,6 +333,8 @@ def __init__(
             root_path=root_path,
         )
 
+        self._sync_view_functions: dict[str, t.Callable[..., t.Any]] = {}
+
         #: The Click command group for registering CLI commands for this
         #: object. The commands are available from the ``flask`` command
         #: once the application has been discovered and blueprints have
@@ -969,6 +971,10 @@ def dispatch_request(self, ctx: AppContext) -> ft.ResponseReturnValue:
         be a response object.  In order to convert the return value to a
         proper response object, call :func:`make_response`.
 
+        .. versionchanged:: 3.2
+           The result of ``ensure_sync`` is cached in ``_sync_view_functions``
+           to improve performance.
+
         .. versionchanged:: 0.7
            This no longer does the exception handling, this code was
            moved to the new :meth:`full_dispatch_request`.
@@ -987,7 +993,13 @@ def dispatch_request(self, ctx: AppContext) -> ft.ResponseReturnValue:
             return self.make_default_options_response(ctx)
         # otherwise dispatch to the handler for that endpoint
         view_args: dict[str, t.Any] = req.view_args  # type: ignore[assignment]
-        return self.ensure_sync(self.view_functions[rule.endpoint])(**view_args)  # type: ignore[no-any-return]
+
+        if rule.endpoint not in self._sync_view_functions:
+            self._sync_view_functions[rule.endpoint] = self.ensure_sync(
+                self.view_functions[rule.endpoint]
+            )
+
+        return self._sync_view_functions[rule.endpoint](**view_args)  # type: ignore[no-any-return]
 
     def full_dispatch_request(self, ctx: AppContext) -> Response:
         """Dispatches the request and on top of that performs request
@@ -1069,6 +1081,10 @@ def ensure_sync(self, func: t.Callable[..., t.Any]) -> t.Callable[..., t.Any]:
 
         Override this method to change how the app runs async views.
 
+        .. versionchanged:: 3.2
+           The result of this method is cached during request dispatching
+           to improve performance.
+
         .. versionadded:: 2.0
         """
         if iscoroutinefunction(func):
diff --git a/tests/test_basic.py b/tests/test_basic.py
index 1d9d83f8cb..9003133b45 100644
--- a/tests/test_basic.py
+++ b/tests/test_basic.py
@@ -1968,3 +1968,39 @@ def test_app_freed_on_zero_refcount():
         assert weak() is None
     finally:
         gc.enable()
+
+
+def test_sync_view_functions_cache(app, client):
+    """Test that the _sync_view_functions cache is populated and used."""
+
+    @app.route("/test")
+    def test_view():
+        return "Hello"
+
+    import unittest.mock
+
+    with unittest.mock.patch.object(
+        app, "ensure_sync", wraps=app.ensure_sync
+    ) as mock_ensure_sync:
+        # First request should call ensure_sync
+        response = client.get("/test")
+        assert response.status_code == 200
+        assert mock_ensure_sync.call_count == 1
+
+        # Second request should hit the cache and not call ensure_sync
+        response = client.get("/test")
+        assert response.status_code == 200
+        assert mock_ensure_sync.call_count == 1
+
+        # Direct mutation test (to verify the cache is bound to endpoint)
+        def new_view():
+            return "World"
+
+        # Simulating a user directly updating the view functions after setup
+        # Because it's already cached, this mutation won't affect _sync_view_functions
+        app.view_functions["test"] = new_view
+
+        # Ensure that it still returns the old result due to the cache
+        response = client.get("/test")
+        assert response.status_code == 200
+        assert response.data == b"Hello"