diff --git a/src/api/python/requirements.bazel.txt b/src/api/python/requirements.bazel.txt
index 58cab4f864a..854737b2009 100644
--- a/src/api/python/requirements.bazel.txt
+++ b/src/api/python/requirements.bazel.txt
@@ -245,7 +245,7 @@ pycparser==2.21 \
     # via cffi
 
 # The following packages are considered to be unsafe in a requirements file:
-setuptools==65.6.3 \
-    --hash=sha256:57f6f22bde4e042978bcd50176fdb381d7c21a9efa4041202288d3737a0c6a54 \
-    --hash=sha256:a7620757bf984b58deaf32fc8a4577a9bbc0850cf92c20e1ce41c38c19e5fb75
+setuptools==78.1.1 \
+    --hash=sha256:c3a9c4211ff4c309edb8b8c4f1cbfa7ae324c4ba9f91ff254e3d305b9fd54561 \
+    --hash=sha256:fcc17fd9cd898242f6b4adfaca46137a9edef687f43e6f78469692a5e70d851d
     # via grpcio-tools