diff --git a/src/components/Application.tsx b/src/components/Application.tsx
index cf3141b6..e19a6a4e 100644
--- a/src/components/Application.tsx
+++ b/src/components/Application.tsx
@@ -26,6 +26,10 @@ import { type ApplicationProps } from '../typedefs/ApplicationProps';
 import { type ApplicationRef } from '../typedefs/ApplicationRef';
 
 const originalDefaultTextStyle = { ...TextStyle.defaultTextStyle };
+const isElementNode = (value: unknown): value is HTMLElement => !!value
+    && typeof value === 'object'
+    && 'nodeType' in value
+    && value.nodeType === 1;
 
 const ApplicationImplementation = forwardRef<ApplicationRef, ApplicationProps>(function Application(
     props,
@@ -71,7 +75,7 @@ const ApplicationImplementation = forwardRef<ApplicationRef, ApplicationProps>(f
             {
                 if ('current' in resizeTo)
                 {
-                    if (resizeTo.current instanceof HTMLElement)
+                    if (isElementNode(resizeTo.current))
                     {
                         application.resizeTo = resizeTo.current;
                     }
diff --git a/src/core/createRoot.tsx b/src/core/createRoot.tsx
index 875782a3..083bfb4f 100644
--- a/src/core/createRoot.tsx
+++ b/src/core/createRoot.tsx
@@ -22,6 +22,9 @@ export function createRoot(
     options: CreateRootOptions = {},
 )
 {
+    const ownerDocument = target.ownerDocument ?? document;
+    const ownerWindow = ownerDocument.defaultView ?? window;
+
     // Check against mistaken use of createRoot
     let root = roots.get(target);
     let applicationState = (root?.applicationState ?? {
@@ -58,21 +61,28 @@ export function createRoot(
 
     if (!root)
     {
-        let canvas;
+        let canvas: HTMLCanvasElement | undefined;
+        const ownerCanvasConstructor = ownerWindow.HTMLCanvasElement;
 
-        if (target instanceof HTMLCanvasElement)
+        if (ownerCanvasConstructor && target instanceof ownerCanvasConstructor)
         {
             canvas = target;
         }
+        else if (target.nodeName === 'CANVAS')
+        {
+            canvas = target as HTMLCanvasElement;
+        }
 
         if (!canvas)
         {
-            canvas = document.createElement('canvas');
+            canvas = ownerDocument.createElement('canvas');
             target.innerHTML = '';
             target.appendChild(canvas);
         }
 
         internalState.canvas = canvas;
+        internalState.ownerDocument = ownerDocument;
+        internalState.ownerWindow = ownerWindow;
 
         const render = async (
             children: ReactNode,
diff --git a/src/typedefs/InternalState.ts b/src/typedefs/InternalState.ts
index 4943bee4..96656bd5 100644
--- a/src/typedefs/InternalState.ts
+++ b/src/typedefs/InternalState.ts
@@ -3,5 +3,7 @@ import { type HostConfig } from './HostConfig';
 export interface InternalState
 {
     canvas?: HTMLCanvasElement;
+    ownerDocument?: Document;
+    ownerWindow?: Window;
     rootContainer: HostConfig['containerInstance'];
 }
diff --git a/test/e2e/components/Application.test.tsx b/test/e2e/components/Application.test.tsx
index 38653707..6669a210 100644
--- a/test/e2e/components/Application.test.tsx
+++ b/test/e2e/components/Application.test.tsx
@@ -2,6 +2,7 @@ import { Application as PixiApplication, type DestroyOptions, extensions as Pixi
 import {
     createContext,
     createRef,
+    type RefObject,
     useContext,
     useEffect,
 } from 'react';
@@ -47,6 +48,32 @@ describe('Application', () =>
         expect(ref.current?.getCanvas()).toBeInstanceOf(HTMLCanvasElement);
     });
 
+    it('supports resizeTo refs from another window', async () =>
+    {
+        const onInitSpy = vi.fn();
+        const appRef = createRef<ApplicationRef>();
+        const iframe = document.createElement('iframe');
+        document.body.appendChild(iframe);
+
+        const iframeDocument = iframe.contentDocument!;
+        const resizeTarget = iframeDocument.createElement('div');
+        iframeDocument.body.appendChild(resizeTarget);
+
+        const resizeToRef = { current: resizeTarget } as RefObject<HTMLElement | null>;
+
+        await act(async () => render((
+            <Application
+                ref={appRef}
+                resizeTo={resizeToRef}
+                onInit={onInitSpy} />
+        )));
+
+        await expect.poll(() => onInitSpy.mock.calls.length).toEqual(1);
+        await expect.poll(() => appRef.current?.getApplication()?.resizeTo).toBe(resizeTarget);
+
+        iframe.remove();
+    });
+
     it('forwards context', async () =>
     {
         const onInitSpy = vi.fn();
diff --git a/test/unit/core/createRoot.test.ts b/test/unit/core/createRoot.test.ts
index 871dbe55..03b9cbb2 100644
--- a/test/unit/core/createRoot.test.ts
+++ b/test/unit/core/createRoot.test.ts
@@ -61,4 +61,30 @@ describe('createRoot', () =>
             expect(root.applicationState.rendererDestroyOptions).toEqual({ removeView: true });
         });
     });
+
+    it('creates roots for iframe-owned elements', () =>
+    {
+        const iframe = document.createElement('iframe');
+        document.body.appendChild(iframe);
+
+        const iframeDocument = iframe.contentDocument!;
+        const iframeCanvas = iframeDocument.createElement('canvas');
+        const iframeContainer = iframeDocument.createElement('div');
+
+        iframeDocument.body.appendChild(iframeCanvas);
+        iframeDocument.body.appendChild(iframeContainer);
+
+        const canvasRoot = createRoot(iframeCanvas as unknown as HTMLCanvasElement);
+        const containerRoot = createRoot(iframeContainer as unknown as HTMLElement);
+
+        const createdCanvas = iframeContainer.querySelector('canvas');
+
+        expect(canvasRoot.applicationState.app).toBeInstanceOf(Application);
+        expect(containerRoot.applicationState.app).toBeInstanceOf(Application);
+        expect(createdCanvas?.nodeName).toBe('CANVAS');
+        expect(createdCanvas?.ownerDocument).toBe(iframeDocument);
+        expect(containerRoot.internalState.canvas).toBe(createdCanvas);
+
+        iframe.remove();
+    });
 });