diff --git a/Doc/library/typing.rst b/Doc/library/typing.rst
index 09e9103e1b80d0..045d4696f9e60a 100644
--- a/Doc/library/typing.rst
+++ b/Doc/library/typing.rst
@@ -2482,6 +2482,10 @@ types.
       Using :func:`super` (and the ``__class__`` :term:`closure variable`) in methods of ``NamedTuple`` subclasses
       is unsupported and causes a :class:`TypeError`.
 
+   .. versionchanged:: next
+      Added support for arbitrary multiple inheritance.
+
+
 .. class:: NewType(name, tp)
 
    Helper class to create low-overhead :ref:`distinct types <distinct>`.
diff --git a/Doc/whatsnew/3.15.rst b/Doc/whatsnew/3.15.rst
index 21327b611120a2..b8394e5b96249f 100644
--- a/Doc/whatsnew/3.15.rst
+++ b/Doc/whatsnew/3.15.rst
@@ -830,9 +830,9 @@ http.server
   is colored by default.
   This can be controlled with :ref:`environment variables
   <using-on-controlling-color>`.
-  (Contributed by Hugo van Kemenade in :gh:`146292`.)
-
-
+  (Contributed by Hugo van Kemenade in :gh:`146292`.)
+
+
 inspect
 -------
 
@@ -1239,6 +1239,11 @@ typing
   as it was incorrectly inferred in runtime before.
   (Contributed by Nikita Sobolev in :gh:`137191`.)
 
+* Add support of multiple inheritance with :class:`~typing.NamedTuple`.
+  Previously, multiple inheritance was only supported if there was exactly
+  one other base and the base was :class:`typing.Generic`.
+  (Contributed by Serhiy Storchaka in :gh:`116241`.)
+
 
 unicodedata
 -----------
diff --git a/Lib/test/test_typing.py b/Lib/test/test_typing.py
index c6f08ff8a052ab..6bba31774a172e 100644
--- a/Lib/test/test_typing.py
+++ b/Lib/test/test_typing.py
@@ -8270,7 +8270,42 @@ class X(NamedTuple):
 
     def test_multiple_inheritance(self):
         class A:
-            pass
+            @property
+            def x(self):
+                return 4
+            @property
+            def y(self):
+                return 5
+            def __len__(self):
+                return 10
+
+        class X(NamedTuple, A):
+            x: int
+        self.assertEqual(X.__bases__, (tuple, A))
+        self.assertEqual(X.__orig_bases__, (NamedTuple, A))
+        self.assertEqual(X.__mro__, (X, tuple, A, object))
+
+        a = X(3)
+        self.assertEqual(a.x, 3)
+        self.assertEqual(a.y, 5)
+        self.assertEqual(len(a), 1)
+        self.assertEqual(list(a), [3])
+
+        class Y(A, NamedTuple):
+            x: int
+        self.assertEqual(Y.__bases__, (A, tuple))
+        self.assertEqual(Y.__orig_bases__, (A, NamedTuple))
+        self.assertEqual(Y.__mro__, (Y, A, tuple, object))
+
+        a = Y(3)
+        self.assertEqual(a.x, 3)
+        self.assertEqual(a.y, 5)
+        self.assertEqual(len(a), 10)
+        self.assertEqual(list(a), [3])
+
+    def test_multiple_inheritance_errors(self):
+        class A(NamedTuple):
+            x: int
         with self.assertRaises(TypeError):
             class X(NamedTuple, A):
                 x: int
diff --git a/Lib/typing.py b/Lib/typing.py
index e78fb8b71a996c..a6a26cda03f85f 100644
--- a/Lib/typing.py
+++ b/Lib/typing.py
@@ -3016,10 +3016,6 @@ def __new__(cls, typename, bases, ns):
         if "__classcell__" in ns:
             raise TypeError(
                 "uses of super() and __class__ are unsupported in methods of NamedTuple subclasses")
-        for base in bases:
-            if base is not _NamedTuple and base is not Generic:
-                raise TypeError(
-                    'can only inherit from a NamedTuple type and Generic')
         bases = tuple(tuple if base is _NamedTuple else base for base in bases)
         if "__annotations__" in ns:
             types = ns["__annotations__"]
diff --git a/Misc/NEWS.d/next/Library/2022-04-28-18-45-58.gh-issue-116241.hu9kRk.rst b/Misc/NEWS.d/next/Library/2022-04-28-18-45-58.gh-issue-116241.hu9kRk.rst
new file mode 100644
index 00000000000000..0cbfb8ad12f6e3
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2022-04-28-18-45-58.gh-issue-116241.hu9kRk.rst
@@ -0,0 +1 @@
+Add support for arbitrary multiple inheritance with :class:`typing.NamedTuple`.