diff --git a/mypyc/lib-rt/CPy.h b/mypyc/lib-rt/CPy.h
index 935852bcf30e5..32daf32520802 100644
--- a/mypyc/lib-rt/CPy.h
+++ b/mypyc/lib-rt/CPy.h
@@ -783,6 +783,7 @@ PyObject *CPyBytes_Concat(PyObject *a, PyObject *b);
 PyObject *CPyBytes_Join(PyObject *sep, PyObject *iter);
 CPyTagged CPyBytes_Ord(PyObject *obj);
 PyObject *CPyBytes_Multiply(PyObject *bytes, CPyTagged count);
+PyObject *CPyBytes_Translate(PyObject *bytes, PyObject *table);
 
 
 int CPyBytes_Compare(PyObject *left, PyObject *right);
diff --git a/mypyc/lib-rt/bytes_ops.c b/mypyc/lib-rt/bytes_ops.c
index 8ecf9337c28b8..6c138ad90db0d 100644
--- a/mypyc/lib-rt/bytes_ops.c
+++ b/mypyc/lib-rt/bytes_ops.c
@@ -171,3 +171,52 @@ PyObject *CPyBytes_Multiply(PyObject *bytes, CPyTagged count) {
     }
     return PySequence_Repeat(bytes, temp_count);
 }
+
+PyObject *CPyBytes_Translate(PyObject *bytes, PyObject *table) {
+    // Fast path: exact bytes object with exact bytes table
+    if (PyBytes_CheckExact(bytes) && PyBytes_CheckExact(table)) {
+        Py_ssize_t table_len = PyBytes_GET_SIZE(table);
+        if (table_len != 256) {
+            PyErr_SetString(PyExc_ValueError,
+                           "translation table must be 256 characters long");
+            return NULL;
+        }
+
+        Py_ssize_t len = PyBytes_GET_SIZE(bytes);
+        const char *input = PyBytes_AS_STRING(bytes);
+        const char *trans_table = PyBytes_AS_STRING(table);
+
+        PyObject *result = PyBytes_FromStringAndSize(NULL, len);
+        if (result == NULL) {
+            return NULL;
+        }
+
+        char *output = PyBytes_AS_STRING(result);
+        bool changed = false;
+
+        // Without a loop unrolling hint performance can be worse than CPython
+        CPY_UNROLL_LOOP(4)
+        for (Py_ssize_t i = len; --i >= 0;) {
+            char c = *input++;
+            if ((*output++ = trans_table[(unsigned char)c]) != c)
+                changed = true;
+        }
+
+        // If nothing changed, discard result and return the original object
+        if (!changed) {
+            Py_DECREF(result);
+            Py_INCREF(bytes);
+            return bytes;
+        }
+
+        return result;
+    }
+
+    // Fallback to Python method call for non-exact types or non-standard tables
+    _Py_IDENTIFIER(translate);
+    PyObject *name = _PyUnicode_FromId(&PyId_translate);
+    if (name == NULL) {
+        return NULL;
+    }
+    return PyObject_CallMethodOneArg(bytes, name, table);
+}
diff --git a/mypyc/lib-rt/mypyc_util.h b/mypyc/lib-rt/mypyc_util.h
index 4168d3c53ee28..50a806c91a8a6 100644
--- a/mypyc/lib-rt/mypyc_util.h
+++ b/mypyc/lib-rt/mypyc_util.h
@@ -48,6 +48,19 @@
 
 #endif // Py_GIL_DISABLED
 
+// Helper macro for stringification in _Pragma
+#define CPY_STRINGIFY(x) #x
+
+#if defined(__clang__)
+    #define CPY_UNROLL_LOOP_IMPL(x) _Pragma(CPY_STRINGIFY(x))
+    #define CPY_UNROLL_LOOP(n) CPY_UNROLL_LOOP_IMPL(unroll n)
+#elif defined(__GNUC__) && __GNUC__ >= 8
+    #define CPY_UNROLL_LOOP_IMPL(x) _Pragma(CPY_STRINGIFY(x))
+    #define CPY_UNROLL_LOOP(n) CPY_UNROLL_LOOP_IMPL(GCC unroll n)
+#else
+    #define CPY_UNROLL_LOOP(n)
+#endif
+
 // INCREF and DECREF that assert the pointer is not NULL.
 // asserts are disabled in release builds so there shouldn't be a perf hit.
 // I'm honestly kind of surprised that this isn't done by default.
diff --git a/mypyc/primitives/bytes_ops.py b/mypyc/primitives/bytes_ops.py
index 858134b204137..982c41dc25b10 100644
--- a/mypyc/primitives/bytes_ops.py
+++ b/mypyc/primitives/bytes_ops.py
@@ -128,6 +128,15 @@
     error_kind=ERR_MAGIC,
 )
 
+# bytes.translate(table)
+method_op(
+    name="translate",
+    arg_types=[bytes_rprimitive, object_rprimitive],
+    return_type=bytes_rprimitive,
+    c_function_name="CPyBytes_Translate",
+    error_kind=ERR_MAGIC,
+)
+
 # Join bytes objects and return a new bytes.
 # The first argument is the total number of the following bytes.
 bytes_build_op = custom_op(
diff --git a/mypyc/test-data/fixtures/ir.py b/mypyc/test-data/fixtures/ir.py
index 5033100223a3d..d9202707124b1 100644
--- a/mypyc/test-data/fixtures/ir.py
+++ b/mypyc/test-data/fixtures/ir.py
@@ -178,6 +178,7 @@ def __getitem__(self, i: int) -> int: ...
     def __getitem__(self, i: slice) -> bytes: ...
     def join(self, x: Iterable[object]) -> bytes: ...
     def decode(self, encoding: str=..., errors: str=...) -> str: ...
+    def translate(self, t: bytes) -> bytes: ...
     def __iter__(self) -> Iterator[int]: ...
 
 class bytearray:
diff --git a/mypyc/test-data/irbuild-bytes.test b/mypyc/test-data/irbuild-bytes.test
index d3bb7d52bf3f3..9473944f44fef 100644
--- a/mypyc/test-data/irbuild-bytes.test
+++ b/mypyc/test-data/irbuild-bytes.test
@@ -238,3 +238,13 @@ def i_times_b(s, n):
 L0:
     r0 = CPyBytes_Multiply(s, n)
     return r0
+
+[case testBytesTranslate]
+def f(b: bytes, table: bytes) -> bytes:
+    return b.translate(table)
+[out]
+def f(b, table):
+    b, table, r0 :: bytes
+L0:
+    r0 = CPyBytes_Translate(b, table)
+    return r0
diff --git a/mypyc/test-data/run-bytes.test b/mypyc/test-data/run-bytes.test
index 1498925f23f5b..9a319b636772f 100644
--- a/mypyc/test-data/run-bytes.test
+++ b/mypyc/test-data/run-bytes.test
@@ -168,6 +168,38 @@ def test_multiply() -> None:
     result = b * two
     assert type(result) == bytes
 
+def test_translate() -> None:
+    # Identity translation table (fast path - exact bytes)
+    identity = bytes(range(256))
+    b = b'hello world' + bytes()
+    assert b.translate(identity) == b'hello world'
+
+    # ROT13-like translation for lowercase letters
+    table = bytearray(range(256))
+    for i in range(ord('a'), ord('z') + 1):
+        table[i] = ord('a') + (i - ord('a') + 13) % 26
+    table_bytes = bytes(table)
+    assert b'hello'.translate(table_bytes) == b'uryyb'
+    assert (b'abc' + bytes()).translate(table_bytes) == b'nop'
+
+    # Test with special characters
+    assert b'\x00\x01\xff'.translate(identity) == b'\x00\x01\xff'
+
+    # Test with bytearray table (slow path - fallback to Python method)
+    bytearray_table = bytearray(range(256))
+    assert b'hello'.translate(bytearray_table) == b'hello'
+    # Modify bytearray table to uppercase
+    for i in range(ord('a'), ord('z') + 1):
+        bytearray_table[i] = ord('A') + (i - ord('a'))
+    assert b'hello world'.translate(bytearray_table) == b'HELLO WORLD'
+    assert (b'test' + bytes()).translate(bytearray_table) == b'TEST'
+
+    # Test error on wrong table size
+    with assertRaises(ValueError, "translation table must be 256 characters long"):
+        b'test'.translate(b'short')
+    with assertRaises(ValueError, "translation table must be 256 characters long"):
+        b'test'.translate(bytes(100))
+
 [case testBytesSlicing]
 def test_bytes_slicing() -> None:
     b = b'abcdefg'