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In the germline case, in order to test the following (non-coding) positive controls, we must remove them from the list of putatively neutral regions upon which we train the model.
Confirm that predicted constraint stratified by collections of genomic elements (e.g., promoters, enhancers, TAD boundaries) mimic corresponding results from other studies (e.g., Figure 2 from https://www.nature.com/articles/s41588-018-0062-7)
In the germline case, in order to test the following (non-coding) positive controls, we must remove them from the list of putatively neutral regions upon which we train the model.