diff --git a/bindings/pyroot/cppyy/CPyCppyy/src/CPyCppyyModule.cxx b/bindings/pyroot/cppyy/CPyCppyy/src/CPyCppyyModule.cxx
index 80c27394f59a8..43c94fda2467d 100644
--- a/bindings/pyroot/cppyy/CPyCppyy/src/CPyCppyyModule.cxx
+++ b/bindings/pyroot/cppyy/CPyCppyy/src/CPyCppyyModule.cxx
@@ -1192,6 +1192,11 @@ PyObject* Init()
 
 #if PY_VERSION_HEX >= 0x03000000
     Py_INCREF(gThisModule);
+#endif
+    // Avoid fallback to the GIL when importing this module in a free-threaded
+    // Python build.
+#ifdef Py_GIL_DISABLED
+    PyUnstable_Module_SetGIL(gThisModule, Py_MOD_GIL_NOT_USED);
 #endif
     return gThisModule;
 }
diff --git a/bindings/pyroot/pythonizations/src/PyROOTModule.cxx b/bindings/pyroot/pythonizations/src/PyROOTModule.cxx
index d6ba1aa297b6d..33d40e49c3438 100644
--- a/bindings/pyroot/pythonizations/src/PyROOTModule.cxx
+++ b/bindings/pyroot/pythonizations/src/PyROOTModule.cxx
@@ -259,5 +259,10 @@ extern "C" PyObject *PyInit_libROOTPythonizations()
    // keep gRootModule, but do not increase its reference count even as it is borrowed,
    // or a self-referencing cycle would be created
 
+   // Avoid fallback to the GIL when importing this module in a free-threaded
+   // Python build.
+#ifdef Py_GIL_DISABLED
+   PyUnstable_Module_SetGIL(gRootModule, Py_MOD_GIL_NOT_USED);
+#endif
    return gRootModule;
 }