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• I have provided the necessary information about my issue.
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As you can in the reprex below, all this does is create a trivial Rmarkdown document in a subdirectory, and then attempt to knit it. Because the RMarkdown document has a space in the name and we have requested github_document, the example errors by having the wrong working directory (the root dir, not the same dir from where the Rmarkdown file is found, as in the usual convention!) Change the output format to html_document, or remove the space in the name, and the error is resolved.

Consider the following reprex:

dir.create("subdir")
download.file("https://gist.githubusercontent.com/cboettig/5ba7013764152c1305bf26d81ec94fbe/raw/0b23bc008f816fdb80f9744da35d7ee78ba5ce4a/Bug%2520Report.Rmd",
"subdir/Bug Report.Rmd")
rmarkdown::render("subdir/Bug Report.Rmd")
#> processing file: Bug-Report.Rmd
#> Quitting from lines 8-10 (Bug-Report.Rmd)
#> Error: file.exists("Bug Report.Rmd") is not TRUE

^{Created on 2020-12-14 by the reprex package (v0.3.0)}