diff --git a/src/main/java/io/github/guacsec/trustifyda/utils/PythonControllerBase.java b/src/main/java/io/github/guacsec/trustifyda/utils/PythonControllerBase.java
index 68ff5c86..8103f9fc 100644
--- a/src/main/java/io/github/guacsec/trustifyda/utils/PythonControllerBase.java
+++ b/src/main/java/io/github/guacsec/trustifyda/utils/PythonControllerBase.java
@@ -181,6 +181,9 @@ private List<Map<String, Object>> getDependenciesImpl(
         if (dep.contains("==")) {
           doubleEqualSignPosition = dep.indexOf("==");
           manifestVersion = dep.substring(doubleEqualSignPosition + 2).trim();
+          if (manifestVersion.contains(";")) {
+            manifestVersion = manifestVersion.substring(0, manifestVersion.indexOf(";")).trim();
+          }
           if (manifestVersion.contains("#")) {
             var hashCharIndex = manifestVersion.indexOf("#");
             manifestVersion = manifestVersion.substring(0, hashCharIndex);
@@ -210,6 +213,10 @@ private List<Map<String, Object>> getDependenciesImpl(
       }
       List<String> path = new ArrayList<>();
       String selectedDepName = getDependencyName(dep.toLowerCase());
+      boolean hasMarker = dep.contains(";");
+      if (hasMarker && cachedEnvironmentDeps.get(new StringInsensitive(selectedDepName)) == null) {
+        continue;
+      }
       path.add(selectedDepName);
       bringAllDependencies(
           dependencies, selectedDepName, cachedEnvironmentDeps, includeTransitive, path);
diff --git a/src/test/java/io/github/guacsec/trustifyda/providers/Python_Provider_Test.java b/src/test/java/io/github/guacsec/trustifyda/providers/Python_Provider_Test.java
index 109b0a65..9c87fb19 100644
--- a/src/test/java/io/github/guacsec/trustifyda/providers/Python_Provider_Test.java
+++ b/src/test/java/io/github/guacsec/trustifyda/providers/Python_Provider_Test.java
@@ -211,6 +211,44 @@ void test_the_provideComponent_with_properties(String testFolder) throws IOExcep
     assertThat(dropIgnored(new String(content.buffer))).isEqualTo(dropIgnored(expectedSbom));
   }
 
+  @Test
+  @RestoreSystemProperties
+  void test_marker_constrained_uninstalled_packages_are_skipped_in_component_analysis()
+      throws IOException {
+    var testFolder = "pip_requirements_txt_marker_skip";
+    var targetRequirements =
+        String.format("src/test/resources/tst_manifests/pip/%s/requirements.txt", testFolder);
+
+    // load expected SBOM
+    String expectedSbom;
+    try (var is =
+        getResourceAsStreamDecision(
+            this.getClass(),
+            String.format("tst_manifests/pip/%s/expected_component_sbom.json", testFolder))) {
+      expectedSbom = new String(is.readAllBytes());
+    }
+
+    // pip environment where only six and certifi are installed (pywin32 is Windows-only)
+    String pipFreezeContent = "six==1.16.0\ncertifi==2023.7.22\n";
+    String pipShowContent =
+        "Name: certifi\nVersion: 2023.7.22\nSummary: Python package for providing Mozilla's CA"
+            + " Bundle.\nRequires: \nRequired-by: \n---\nName: six\nVersion: 1.16.0\nSummary:"
+            + " Python 2 and 3 compatibility utilities\nRequires: \nRequired-by: ";
+    System.setProperty(
+        PROP_TRUSTIFY_DA_PIP_FREEZE,
+        new String(Base64.getEncoder().encode(pipFreezeContent.getBytes())));
+    System.setProperty(
+        PROP_TRUSTIFY_DA_PIP_SHOW,
+        new String(Base64.getEncoder().encode(pipShowContent.getBytes())));
+
+    // when providing component content for a manifest with a Windows-only marker package
+    var content = new PythonPipProvider(Path.of(targetRequirements)).provideComponent();
+
+    // then SBOM contains six and certifi but not pywin32
+    assertThat(content.type).isEqualTo(Api.CYCLONEDX_MEDIA_TYPE);
+    assertThat(dropIgnored(new String(content.buffer))).isEqualTo(dropIgnored(expectedSbom));
+  }
+
   @Test
   void Test_The_ProvideComponent_Path_Should_Throw_Exception() {
     assertThatIllegalArgumentException()
diff --git a/src/test/resources/tst_manifests/pip/pip_requirements_txt_marker_skip/expected_component_sbom.json b/src/test/resources/tst_manifests/pip/pip_requirements_txt_marker_skip/expected_component_sbom.json
new file mode 100644
index 00000000..af333b2a
--- /dev/null
+++ b/src/test/resources/tst_manifests/pip/pip_requirements_txt_marker_skip/expected_component_sbom.json
@@ -0,0 +1,48 @@
+{
+  "bomFormat" : "CycloneDX",
+  "specVersion" : "1.4",
+  "version" : 1,
+  "metadata" : {
+    "timestamp" : "2025-04-09T12:38:18Z",
+    "component" : {
+      "type" : "application",
+      "bom-ref" : "pkg:pypi/default-pip-root@0.0.0",
+      "name" : "default-pip-root",
+      "version" : "0.0.0",
+      "purl" : "pkg:pypi/default-pip-root@0.0.0"
+    }
+  },
+  "components" : [
+    {
+      "type" : "library",
+      "bom-ref" : "pkg:pypi/six@1.16.0",
+      "name" : "six",
+      "version" : "1.16.0",
+      "purl" : "pkg:pypi/six@1.16.0"
+    },
+    {
+      "type" : "library",
+      "bom-ref" : "pkg:pypi/certifi@2023.7.22",
+      "name" : "certifi",
+      "version" : "2023.7.22",
+      "purl" : "pkg:pypi/certifi@2023.7.22"
+    }
+  ],
+  "dependencies" : [
+    {
+      "ref" : "pkg:pypi/default-pip-root@0.0.0",
+      "dependsOn" : [
+        "pkg:pypi/six@1.16.0",
+        "pkg:pypi/certifi@2023.7.22"
+      ]
+    },
+    {
+      "ref" : "pkg:pypi/six@1.16.0",
+      "dependsOn" : [ ]
+    },
+    {
+      "ref" : "pkg:pypi/certifi@2023.7.22",
+      "dependsOn" : [ ]
+    }
+  ]
+}
diff --git a/src/test/resources/tst_manifests/pip/pip_requirements_txt_marker_skip/requirements.txt b/src/test/resources/tst_manifests/pip/pip_requirements_txt_marker_skip/requirements.txt
new file mode 100644
index 00000000..f8c35ddd
--- /dev/null
+++ b/src/test/resources/tst_manifests/pip/pip_requirements_txt_marker_skip/requirements.txt
@@ -0,0 +1,3 @@
+six==1.16.0
+certifi==2023.7.22 ; python_version >= "3"
+pywin32==306 ; platform_system == "Windows"