diff --git a/packages/react-native-gesture-handler/src/handlers/gestures/GestureDetector/useMountReactions.ts b/packages/react-native-gesture-handler/src/handlers/gestures/GestureDetector/useMountReactions.ts
index 84732ddbb1..12c37f7cdb 100644
--- a/packages/react-native-gesture-handler/src/handlers/gestures/GestureDetector/useMountReactions.ts
+++ b/packages/react-native-gesture-handler/src/handlers/gestures/GestureDetector/useMountReactions.ts
@@ -28,6 +28,12 @@ export function useMountReactions(
 ) {
   useEffect(() => {
     return MountRegistry.addMountListener((gesture) => {
+      // The detector may already be unmounted when this fires; bail out to avoid
+      // updating a detached detector.
+      if (!state.isMounted) {
+        return;
+      }
+
       // At this point the ref in the gesture config should be updated, so we can check if one of the gestures
       // set in a relation with the gesture got mounted. If so, we need to update the detector to propagate
       // the changes to the native side.