[ECC] Vascular Proliferation

[madetunj]

Getting Started Checklist

• I have searched through the GitHub issues with the K-ecc tag and ensured that no one has proposed this ECC before (or that it is not already captured in an existing ECC).

Proposed Characteristic Name

Vascular Proliferation

Proposed Characteristic Category

Morphological

Detailed Description

Vascular Proliferation

Characteristics

Mutation Link: NULL
Assignment: Histopathological
Creators: Modupe Adetunji, Van Nguyen
First Discovered: Judah Folkman, NEJM 1971.

Description

Rapid blood vessel growth 12456339; 24612214.

Evaluation

• Imunohistochemistry (IHC) of angiogenesis-related markers like CD34, VEGF, FVIII-RA, CD31, Ki-67.
• H&E staining
• qPCR to measure expression levels of angiopoietins and/or VEGF 10669954, 3780177.

References

• Vascular smooth muscle hyperplasia underlies the formation of glomeruloid vascular structures of glioblastoma multiforme
• Proliferative potential of vascular components in human glioblastoma multiforme
• Early and extensive contribution of pericytes/vascular smooth muscle cells to microvascular proliferation in glioblastoma multiforme: an immuno-light and immuno-electron microscopic study
• Genetic modulation of hypoxia induced gene expression and angiogenesis: relevance to brain tumors
• Angiogenesis and expression of PDGF-C, VEGF, CD105 and HIF-1α in human glioblastoma

Status

Ratification status of the ECC: NULL
Version number: .01
Development phase: draft