diff --git a/src/core/plugins/oas3/components/request-body.jsx b/src/core/plugins/oas3/components/request-body.jsx
index 388f5cc6662..1e554a3c37c 100644
--- a/src/core/plugins/oas3/components/request-body.jsx
+++ b/src/core/plugins/oas3/components/request-body.jsx
@@ -114,12 +114,22 @@ const RequestBody = ({
     const Input = getComponent("Input")
 
     if(!isExecute) {
-      return <i>
-        Example values are not available for <code>{contentType}</code> media types.
-      </i>
+      return <div>
+        { requestBodyDescription &&
+          <Markdown source={requestBodyDescription} />
+        }
+        <i>
+          Example values are not available for <code>{contentType}</code> media types.
+        </i>
+      </div>
     }
 
-    return <Input type={"file"} onChange={handleFile} />
+    return <div>
+      { requestBodyDescription &&
+        <Markdown source={requestBodyDescription} />
+      }
+      <Input type={"file"} onChange={handleFile} />
+    </div>
   }
 
 
diff --git a/test/e2e-cypress/e2e/features/plugins/oas3/request-body-file-upload-description.cy.js b/test/e2e-cypress/e2e/features/plugins/oas3/request-body-file-upload-description.cy.js
new file mode 100644
index 00000000000..98bb61d1cef
--- /dev/null
+++ b/test/e2e-cypress/e2e/features/plugins/oas3/request-body-file-upload-description.cy.js
@@ -0,0 +1,155 @@
+/**
+ * @prettier
+ */
+
+describe("OpenAPI 3.0 Request Body description on file upload content types", () => {
+  beforeEach(() => {
+    cy.visit(
+      "/?url=/documents/features/oas3-request-body-file-upload-description.yaml"
+    )
+  })
+
+  describe("application/octet-stream (with schema)", () => {
+    beforeEach(() => {
+      cy.get("#operations-default-uploadApplicationOctetStream").click()
+    })
+
+    it("renders the Markdown description before Try it out is enabled", () => {
+      cy.get(
+        ".opblock-section-request-body .opblock-description-wrapper .renderedMarkdown"
+      )
+        .should("exist")
+        .and("contain.text", "Upload a binary blob")
+      cy.get(
+        ".opblock-section-request-body .opblock-description-wrapper .renderedMarkdown strong"
+      ).should("have.text", "Upload a binary blob")
+      cy.get(
+        ".opblock-section-request-body .opblock-description-wrapper i"
+      ).should(
+        "have.text",
+        "Example values are not available for application/octet-stream media types."
+      )
+    })
+
+    it("renders the Markdown description after Try it out is enabled", () => {
+      cy.get(".try-out__btn").click()
+      cy.get(
+        ".opblock-section-request-body .opblock-description-wrapper .renderedMarkdown"
+      )
+        .should("exist")
+        .and("contain.text", "Upload a binary blob")
+      cy.get(
+        ".opblock-section-request-body .opblock-description-wrapper input"
+      ).should("have.prop", "type", "file")
+    })
+  })
+
+  describe("image/png", () => {
+    beforeEach(() => {
+      cy.get("#operations-default-uploadImagePng").click()
+    })
+
+    it("renders the Markdown description before Try it out is enabled", () => {
+      cy.get(
+        ".opblock-section-request-body .opblock-description-wrapper .renderedMarkdown"
+      )
+        .should("exist")
+        .and("contain.text", "Upload a PNG image")
+      cy.get(
+        ".opblock-section-request-body .opblock-description-wrapper .renderedMarkdown em"
+      ).should("have.text", "Upload a PNG image")
+    })
+
+    it("renders the Markdown description after Try it out is enabled", () => {
+      cy.get(".try-out__btn").click()
+      cy.get(
+        ".opblock-section-request-body .opblock-description-wrapper .renderedMarkdown"
+      )
+        .should("exist")
+        .and("contain.text", "Upload a PNG image")
+      cy.get(
+        ".opblock-section-request-body .opblock-description-wrapper input"
+      ).should("have.prop", "type", "file")
+    })
+  })
+
+  describe("application/octet-stream with empty Media Type Object", () => {
+    beforeEach(() => {
+      cy.get("#operations-default-uploadApplicationOctetStreamEmpty").click()
+    })
+
+    it("renders the Markdown description before Try it out is enabled", () => {
+      cy.get(
+        ".opblock-section-request-body .opblock-description-wrapper .renderedMarkdown"
+      )
+        .should("exist")
+        .and("contain.text", "Empty media type object")
+    })
+
+    it("renders the Markdown description after Try it out is enabled", () => {
+      cy.get(".try-out__btn").click()
+      cy.get(
+        ".opblock-section-request-body .opblock-description-wrapper .renderedMarkdown"
+      )
+        .should("exist")
+        .and("contain.text", "Empty media type object")
+      cy.get(
+        ".opblock-section-request-body .opblock-description-wrapper input"
+      ).should("have.prop", "type", "file")
+    })
+  })
+
+  describe("schema type string and format binary", () => {
+    beforeEach(() => {
+      cy.get("#operations-default-uploadSchemaFormatBinary").click()
+    })
+
+    it("renders the Markdown description before Try it out is enabled", () => {
+      cy.get(
+        ".opblock-section-request-body .opblock-description-wrapper .renderedMarkdown"
+      )
+        .should("exist")
+        .and("contain.text", "application/x-custom")
+    })
+
+    it("renders the Markdown description after Try it out is enabled", () => {
+      cy.get(".try-out__btn").click()
+      cy.get(
+        ".opblock-section-request-body .opblock-description-wrapper .renderedMarkdown"
+      )
+        .should("exist")
+        .and("contain.text", "application/x-custom")
+      cy.get(
+        ".opblock-section-request-body .opblock-description-wrapper input"
+      ).should("have.prop", "type", "file")
+    })
+  })
+
+  describe("file upload without a requestBody description", () => {
+    beforeEach(() => {
+      cy.get("#operations-default-uploadWithoutDescription").click()
+    })
+
+    it("does not render a Markdown block when description is absent (before Try it out)", () => {
+      cy.get(
+        ".opblock-section-request-body .opblock-description-wrapper .renderedMarkdown"
+      ).should("not.exist")
+      cy.get(
+        ".opblock-section-request-body .opblock-description-wrapper i"
+      ).should(
+        "have.text",
+        "Example values are not available for application/octet-stream media types."
+      )
+    })
+
+    it("does not render a Markdown block when description is absent (after Try it out)", () => {
+      cy.get(".try-out__btn").click()
+      cy.get(
+        ".opblock-section-request-body .opblock-description-wrapper .renderedMarkdown"
+      ).should("not.exist")
+      cy.get(
+        ".opblock-section-request-body .opblock-description-wrapper input"
+      ).should("have.prop", "type", "file")
+    })
+  })
+})
diff --git a/test/e2e-cypress/static/documents/features/oas3-request-body-file-upload-description.yaml b/test/e2e-cypress/static/documents/features/oas3-request-body-file-upload-description.yaml
new file mode 100644
index 00000000000..b75a46d13b3
--- /dev/null
+++ b/test/e2e-cypress/static/documents/features/oas3-request-body-file-upload-description.yaml
@@ -0,0 +1,54 @@
+openapi: 3.0.4
+info:
+  title: "Request body description on file upload content types"
+  description: |-
+    This document exercises rendering of `requestBody.description` (Markdown)
+    on file-upload-intended content types. The description should render both
+    before and after "Try it out" is enabled.
+  version: "1.0.0"
+paths:
+  /upload-application-octet-stream:
+    post:
+      operationId: uploadApplicationOctetStream
+      requestBody:
+        description: |-
+          **Upload a binary blob** as `application/octet-stream`.
+          See [the docs](https://example.com) for details.
+        content:
+          application/octet-stream:
+            schema:
+              type: string
+  /upload-image-png:
+    post:
+      operationId: uploadImagePng
+      requestBody:
+        description: "*Upload a PNG image* of the user avatar."
+        content:
+          image/png:
+            schema:
+              type: string
+  /upload-application-octet-stream-empty:
+    post:
+      operationId: uploadApplicationOctetStreamEmpty
+      requestBody:
+        description: "Empty media type object with **octet-stream** description."
+        content:
+          application/octet-stream: {}
+  /upload-schema-format-binary:
+    post:
+      operationId: uploadSchemaFormatBinary
+      requestBody:
+        description: "`application/x-custom` with **binary** format."
+        content:
+          application/x-custom:
+            schema:
+              type: string
+              format: binary
+  /upload-without-description:
+    post:
+      operationId: uploadWithoutDescription
+      requestBody:
+        content:
+          application/octet-stream:
+            schema:
+              type: string
diff --git a/test/unit/core/plugins/oas3/components/request-body.jsx b/test/unit/core/plugins/oas3/components/request-body.jsx
new file mode 100644
index 00000000000..d97190d3d3d
--- /dev/null
+++ b/test/unit/core/plugins/oas3/components/request-body.jsx
@@ -0,0 +1,145 @@
+/**
+ * @prettier
+ */
+import React from "react"
+import PropTypes from "prop-types"
+import { shallow } from "enzyme"
+import { fromJS, List } from "immutable"
+
+import RequestBody from "core/plugins/oas3/components/request-body"
+
+describe("<RequestBody/>", function () {
+  const Markdown = ({ source }) => <div className="markdown-stub">{source}</div>
+  Markdown.propTypes = { source: PropTypes.string }
+  const Input = () => null
+  const RequestBodyEditor = () => null
+  const HighlightCode = () => null
+  const ModelExample = () => null
+  const ExamplesSelectValueRetainer = () => null
+  const Example = () => null
+  const ParameterIncludeEmpty = () => null
+
+  const components = {
+    Markdown,
+    Input,
+    RequestBodyEditor,
+    HighlightCode,
+    modelExample: ModelExample,
+    ExamplesSelectValueRetainer,
+    Example,
+    ParameterIncludeEmpty,
+  }
+
+  const getComponentStub = (name) => components[name] || null
+
+  const baseProps = {
+    userHasEditedBody: false,
+    requestBodyValue: fromJS({}),
+    requestBodyInclusionSetting: fromJS({}),
+    requestBodyErrors: List(),
+    getComponent: getComponentStub,
+    getConfigs: () => ({}),
+    specSelectors: {},
+    fn: {
+      isFileUploadIntended: () => true,
+      hasSchemaType: () => false,
+      getSampleSchema: () => "",
+    },
+    specPath: List(),
+    onChange: () => {},
+    onChangeIncludeEmpty: () => {},
+    updateActiveExamplesKey: () => {},
+    setRetainRequestBodyValueFlag: () => {},
+    oas3Actions: {},
+  }
+
+  it("renders the request body description for file upload content types when isExecute is true", function () {
+    const props = {
+      ...baseProps,
+      isExecute: true,
+      contentType: "application/octet-stream",
+      requestBody: fromJS({
+        description: "A zip file containing files that will be unzipped",
+        content: {
+          "application/octet-stream": {
+            schema: { type: "string", format: "binary" },
+          },
+        },
+      }),
+    }
+
+    const wrapper = shallow(<RequestBody {...props} />)
+
+    const markdown = wrapper.find(Markdown)
+    expect(markdown.length).toEqual(1)
+    expect(markdown.prop("source")).toEqual(
+      "A zip file containing files that will be unzipped"
+    )
+    expect(wrapper.find(Input).length).toEqual(1)
+  })
+
+  it("renders the request body description for file upload content types when isExecute is false", function () {
+    const props = {
+      ...baseProps,
+      isExecute: false,
+      contentType: "application/octet-stream",
+      requestBody: fromJS({
+        description: "A zip file containing files that will be unzipped",
+        content: {
+          "application/octet-stream": {
+            schema: { type: "string", format: "binary" },
+          },
+        },
+      }),
+    }
+
+    const wrapper = shallow(<RequestBody {...props} />)
+
+    const markdown = wrapper.find(Markdown)
+    expect(markdown.length).toEqual(1)
+    expect(markdown.prop("source")).toEqual(
+      "A zip file containing files that will be unzipped"
+    )
+    expect(wrapper.text()).toContain("Example values are not available")
+  })
+
+  it("does not render a Markdown description when the request body has none (isExecute true)", function () {
+    const props = {
+      ...baseProps,
+      isExecute: true,
+      contentType: "application/octet-stream",
+      requestBody: fromJS({
+        content: {
+          "application/octet-stream": {
+            schema: { type: "string", format: "binary" },
+          },
+        },
+      }),
+    }
+
+    const wrapper = shallow(<RequestBody {...props} />)
+
+    expect(wrapper.find(Markdown).length).toEqual(0)
+    expect(wrapper.find(Input).length).toEqual(1)
+  })
+
+  it("does not render a Markdown description when the request body has none (isExecute false)", function () {
+    const props = {
+      ...baseProps,
+      isExecute: false,
+      contentType: "application/octet-stream",
+      requestBody: fromJS({
+        content: {
+          "application/octet-stream": {
+            schema: { type: "string", format: "binary" },
+          },
+        },
+      }),
+    }
+
+    const wrapper = shallow(<RequestBody {...props} />)
+
+    expect(wrapper.find(Markdown).length).toEqual(0)
+    expect(wrapper.text()).toContain("Example values are not available")
+  })
+})