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| 1 | +//! Dynamic Ontology Usage Examples |
| 2 | +//! |
| 3 | +//! This example demonstrates how to use the Dynamic Ontology pipeline |
| 4 | +//! for extracting entities from text and normalizing them to an ontology. |
| 5 | +
|
| 6 | +use terraphim_types::hgnc::HgncNormalizer; |
| 7 | +use terraphim_types::{ |
| 8 | + CoverageSignal, EntityType, ExtractedEntity, GroundingMetadata, RelationshipType, SchemaSignal, |
| 9 | +}; |
| 10 | + |
| 11 | +fn main() { |
| 12 | + println!("=== Dynamic Ontology Usage Examples ===\n"); |
| 13 | + |
| 14 | + // Example 1: HGNC Gene Normalization |
| 15 | + println!("1. HGNC Gene Normalization"); |
| 16 | + println!("---------------------------"); |
| 17 | + example_hgnc_normalization(); |
| 18 | + |
| 19 | + // Example 2: Coverage Signal |
| 20 | + println!("\n2. Coverage Signal Calculation"); |
| 21 | + println!("-------------------------------"); |
| 22 | + example_coverage_signal(); |
| 23 | + |
| 24 | + // Example 3: Schema Signal Creation |
| 25 | + println!("\n3. Schema Signal Creation"); |
| 26 | + println!("-------------------------"); |
| 27 | + example_schema_signal(); |
| 28 | + |
| 29 | + // Example 4: Full Pipeline |
| 30 | + println!("\n4. Full Extraction Pipeline"); |
| 31 | + println!("-----------------------------"); |
| 32 | + example_full_pipeline(); |
| 33 | +} |
| 34 | + |
| 35 | +fn example_hgnc_normalization() { |
| 36 | + // Create a new HGNC normalizer with oncology genes |
| 37 | + let normalizer = HgncNormalizer::new(); |
| 38 | + |
| 39 | + // Test exact match |
| 40 | + let result = normalizer.normalize("EGFR"); |
| 41 | + println!(" EGFR -> {:?}", result.map(|g| g.normalized_label)); |
| 42 | + |
| 43 | + // Test alias (ERBB1 is an alias for EGFR) |
| 44 | + let result = normalizer.normalize("ERBB1"); |
| 45 | + println!( |
| 46 | + " ERBB1 (alias) -> {:?}", |
| 47 | + result.map(|g| g.normalized_label) |
| 48 | + ); |
| 49 | + |
| 50 | + // Test alias (HER2 is an alias for ERBB2) |
| 51 | + let result = normalizer.normalize("HER2"); |
| 52 | + println!(" HER2 (alias) -> {:?}", result.map(|g| g.normalized_label)); |
| 53 | + |
| 54 | + // Test fuzzy variant (EGFRvIII is a variant of EGFR) |
| 55 | + let result = normalizer.normalize("EGFRvIII"); |
| 56 | + println!( |
| 57 | + " EGFRvIII (fuzzy) -> {:?}", |
| 58 | + result.map(|g| g.normalized_label) |
| 59 | + ); |
| 60 | + |
| 61 | + // Test TP53 |
| 62 | + let result = normalizer.normalize("TP53"); |
| 63 | + println!(" TP53 -> {:?}", result.map(|g| g.normalized_label)); |
| 64 | + |
| 65 | + // Test unknown gene |
| 66 | + let result = normalizer.normalize("XYZ123"); |
| 67 | + println!(" XYZ123 (unknown) -> {:?}", result); |
| 68 | +} |
| 69 | + |
| 70 | +fn example_coverage_signal() { |
| 71 | + // Create entities with varying grounding |
| 72 | + let entities = vec![ |
| 73 | + ExtractedEntity { |
| 74 | + entity_type: EntityType::CancerDiagnosis, |
| 75 | + raw_value: "non-small cell lung cancer".to_string(), |
| 76 | + normalized_value: Some("Non-Small Cell Lung Cancer".to_string()), |
| 77 | + grounding: Some(GroundingMetadata::new( |
| 78 | + "http://example.org/nsclc".to_string(), |
| 79 | + "Non-Small Cell Lung Cancer".to_string(), |
| 80 | + "NCIt".to_string(), |
| 81 | + 0.95, |
| 82 | + terraphim_types::NormalizationMethod::Exact, |
| 83 | + )), |
| 84 | + }, |
| 85 | + ExtractedEntity { |
| 86 | + entity_type: EntityType::Drug, |
| 87 | + raw_value: "Osimertinib".to_string(), |
| 88 | + normalized_value: Some("Osimertinib".to_string()), |
| 89 | + grounding: Some(GroundingMetadata::new( |
| 90 | + "http://example.org/osimertinib".to_string(), |
| 91 | + "Osimertinib".to_string(), |
| 92 | + "NCIt".to_string(), |
| 93 | + 0.98, |
| 94 | + terraphim_types::NormalizationMethod::Exact, |
| 95 | + )), |
| 96 | + }, |
| 97 | + ExtractedEntity { |
| 98 | + entity_type: EntityType::GenomicVariant, |
| 99 | + raw_value: "Unknown mutation".to_string(), |
| 100 | + normalized_value: None, |
| 101 | + grounding: None, |
| 102 | + }, |
| 103 | + ]; |
| 104 | + |
| 105 | + // Calculate categories |
| 106 | + let categories: Vec<String> = entities |
| 107 | + .iter() |
| 108 | + .map(|e| e.normalized_value.clone().unwrap_or(e.raw_value.clone())) |
| 109 | + .collect(); |
| 110 | + |
| 111 | + // Count matched (entities with grounding) |
| 112 | + let matched = entities.iter().filter(|e| e.grounding.is_some()).count(); |
| 113 | + |
| 114 | + // Compute coverage with 0.7 threshold |
| 115 | + let coverage = CoverageSignal::compute(&categories, matched, 0.7); |
| 116 | + |
| 117 | + println!(" Total categories: {}", coverage.total_categories); |
| 118 | + println!(" Matched categories: {}", coverage.matched_categories); |
| 119 | + println!(" Coverage ratio: {:.1}%", coverage.coverage_ratio * 100.0); |
| 120 | + println!(" Threshold: {:.0}%", coverage.threshold * 100.0); |
| 121 | + println!(" Needs review: {}", coverage.needs_review); |
| 122 | +} |
| 123 | + |
| 124 | +fn example_schema_signal() { |
| 125 | + // Create a schema signal from extracted oncology data |
| 126 | + let entities = vec![ |
| 127 | + ExtractedEntity { |
| 128 | + entity_type: EntityType::CancerDiagnosis, |
| 129 | + raw_value: "lung carcinoma".to_string(), |
| 130 | + normalized_value: Some("Lung Carcinoma".to_string()), |
| 131 | + grounding: Some(GroundingMetadata::new( |
| 132 | + "http://example.org/lung_carcinoma".to_string(), |
| 133 | + "Lung Carcinoma".to_string(), |
| 134 | + "NCIt".to_string(), |
| 135 | + 0.95, |
| 136 | + terraphim_types::NormalizationMethod::Exact, |
| 137 | + )), |
| 138 | + }, |
| 139 | + ExtractedEntity { |
| 140 | + entity_type: EntityType::GenomicVariant, |
| 141 | + raw_value: "EGFR L858R".to_string(), |
| 142 | + normalized_value: Some("EGFR L858R".to_string()), |
| 143 | + grounding: None, |
| 144 | + }, |
| 145 | + ]; |
| 146 | + |
| 147 | + let relationships = vec![]; |
| 148 | + |
| 149 | + let schema_signal = SchemaSignal { |
| 150 | + entities, |
| 151 | + relationships, |
| 152 | + confidence: 0.5, |
| 153 | + }; |
| 154 | + |
| 155 | + println!(" Entities: {}", schema_signal.entities.len()); |
| 156 | + println!(" Relationships: {}", schema_signal.relationships.len()); |
| 157 | + println!(" Confidence: {:.0}%", schema_signal.confidence * 100.0); |
| 158 | +} |
| 159 | + |
| 160 | +fn example_full_pipeline() { |
| 161 | + println!(" Step 1: Extract entities from text"); |
| 162 | + println!( |
| 163 | + " Input: 'Patient with EGFR L858R mutation in lung carcinoma treated with Osimertinib'" |
| 164 | + ); |
| 165 | + println!( |
| 166 | + " -> Extract: EGFR L858R (GenomicVariant), lung carcinoma (CancerDiagnosis), Osimertinib (Drug)" |
| 167 | + ); |
| 168 | + |
| 169 | + println!("\n Step 2: Normalize entities to ontology"); |
| 170 | + let normalizer = HgncNormalizer::new(); |
| 171 | + |
| 172 | + // Normalize EGFR |
| 173 | + let egfr = normalizer.normalize("EGFR"); |
| 174 | + println!( |
| 175 | + " EGFR -> {}", |
| 176 | + egfr.as_ref() |
| 177 | + .map(|g| format!( |
| 178 | + "{} (score: {:.2})", |
| 179 | + g.normalized_label.as_ref().unwrap(), |
| 180 | + g.normalized_score.unwrap() |
| 181 | + )) |
| 182 | + .unwrap_or_else(|| "Not found".to_string()) |
| 183 | + ); |
| 184 | + |
| 185 | + println!("\n Step 3: Check coverage"); |
| 186 | + println!(" 2/3 entities grounded = 66.7% coverage"); |
| 187 | + println!(" Threshold: 70% -> needs review: true"); |
| 188 | + |
| 189 | + println!("\n Step 4: Review (if needed)"); |
| 190 | + println!(" Review Agent suggests corrections for unmatched entities"); |
| 191 | + |
| 192 | + println!("\n Result: Grounded knowledge graph with coverage signal"); |
| 193 | +} |
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