projection_groups.jsonl

{"id": "kind_excitatory", "mode": "kind", "key": "excitatory", "name": "Glutamate", "description": "The brain's main excitatory transmitter: glutamatergic projections drive their targets, including the corticostriatal and thalamocortical pathways.", "classification_provenance": "llm", "wikipedia": "https://en.wikipedia.org/wiki/Glutamate_(neurotransmitter)", "wikipedia_provenance": "sourced", "sources": [{"corpus": "stahl_essential", "provenance": "verified", "page": 112, "quote": "Glutamate is the major excitatory neurotransmitter in the central nervous system"}]}
{"id": "kind_inhibitory", "mode": "kind", "key": "inhibitory", "name": "GABA", "description": "The brain's main inhibitory transmitter: GABAergic projections suppress their targets, including the striatal output of the basal ganglia.", "classification_provenance": "llm", "wikipedia": "https://en.wikipedia.org/wiki/Gamma-Aminobutyric_acid", "wikipedia_provenance": "sourced", "sources": [{"corpus": "stahl_essential", "provenance": "verified", "page": 271, "quote": "GABA is the principle inhibitory neurotransmitter in the brain, and normally serves an important regulatory role in reducing the activity of many neurons."}]}
{"id": "kind_dopaminergic", "mode": "kind", "key": "dopaminergic", "name": "Dopamine", "description": "Dopaminergic projections from the midbrain (substantia nigra, VTA) modulate movement, motivation and reward.", "classification_provenance": "llm", "wikipedia": "https://en.wikipedia.org/wiki/Dopaminergic_pathways", "wikipedia_provenance": "sourced", "sources": [{"corpus": "kandel", "provenance": "verified", "page": 982, "quote": "The substantia nigra pars compacta/ventral tegmental area contain an important population of dopaminergic neurons. These neurons represent the third major input station of the basal ganglia and give rise to the nigrostriatal and mesolimbic/mesocortical dopamine projections."}]}
{"id": "kind_cholinergic", "mode": "kind", "key": "cholinergic", "name": "Acetylcholine", "description": "Cholinergic projections modulate arousal, attention and memory across the cortex and hippocampus.", "classification_provenance": "llm", "wikipedia": "https://en.wikipedia.org/wiki/Cholinergic", "wikipedia_provenance": "sourced", "sources": [{"corpus": "kandel", "provenance": "verified", "page": 1047, "quote": "These neurons project throughout the cerebral cortex, hippocampus, and amygdala. Both groups play an important role in arousal, and the basal forebrain groups are also involved in more selective attention."}]}
{"id": "kind_neuroendocrine", "mode": "kind", "key": "neuroendocrine", "name": "Releasing hormones", "description": "Hypothalamic neuroendocrine projections release hormones that control the pituitary and the body's endocrine axes.", "classification_provenance": "llm", "wikipedia": "https://en.wikipedia.org/wiki/Releasing_hormone", "wikipedia_provenance": "sourced", "sources": [{"corpus": "kandel", "provenance": "verified", "page": 1075, "quote": "A group of hypothalamic peptide hormones that control pituitary hormone secretion from the five classic endocrine cell types in the anterior pituitary."}]}
{"id": "kind_serotonergic", "mode": "kind", "key": "serotonergic", "name": "Serotonin", "description": "Serotonergic projections from the raphe nuclei diffusely modulate mood, sleep and appetite throughout the brain.", "classification_provenance": "llm", "wikipedia": "https://en.wikipedia.org/wiki/Serotonergic", "wikipedia_provenance": "sourced", "sources": [{"corpus": "kandel", "provenance": "verified", "page": 1048, "quote": "The B5-B7 neurons in the pons mainly provide serotonergic innervation of the thalamus, hypothalamus, and cerebral cortex."}]}
{"id": "kind_noradrenergic", "mode": "kind", "key": "noradrenergic", "name": "Noradrenaline", "description": "Noradrenergic projections from the locus coeruleus modulate arousal, vigilance and the stress response.", "classification_provenance": "llm", "wikipedia": "https://en.wikipedia.org/wiki/Norepinephrine", "wikipedia_provenance": "sourced", "sources": [{"corpus": "kandel", "provenance": "verified", "page": 1561, "quote": "The major noradrenergic projection of the forebrain arises in the locus ceruleus."}]}
{"id": "sign_excitatory", "mode": "sign", "key": "excitatory", "name": "Excitatory", "description": "Excitatory pathways depolarize their target, making it more likely to fire (mainly glutamatergic).", "classification_provenance": "llm", "wikipedia": "https://en.wikipedia.org/wiki/Excitatory_postsynaptic_potential", "wikipedia_provenance": "sourced", "sources": [{"corpus": "stahl_essential", "provenance": "verified", "page": 112, "quote": "Glutamate is the major excitatory neurotransmitter in the central nervous system"}]}
{"id": "sign_inhibitory", "mode": "sign", "key": "inhibitory", "name": "Inhibitory", "description": "Inhibitory pathways hyperpolarize their target, making it less likely to fire (mainly GABAergic).", "classification_provenance": "llm", "wikipedia": "https://en.wikipedia.org/wiki/Inhibitory_postsynaptic_potential", "wikipedia_provenance": "sourced", "sources": [{"corpus": "stahl_essential", "provenance": "verified", "page": 271, "quote": "GABA is the principle inhibitory neurotransmitter in the brain, and normally serves an important regulatory role in reducing the activity of many neurons."}]}
{"id": "sign_modulatory", "mode": "sign", "key": "modulatory", "name": "Modulatory", "description": "Modulatory pathways (the monoamines and acetylcholine) tune the gain and excitability of their targets rather than directly exciting or inhibiting them.", "classification_provenance": "llm", "wikipedia": "https://en.wikipedia.org/wiki/Neuromodulation", "wikipedia_provenance": "sourced", "sources": [{"corpus": "kandel", "provenance": "verified", "page": 368, "quote": "Neuromodulators are substances that bind to receptors, most of which are metabotropic, to alter the excitability of neurons, the likelihood of transmitter release, or the functional state of receptors on postsynaptic neurons."}]}