rpact: Confirmatory Adaptive Clinical Trial Design and Analysis
A Shiny app for graphical multiplicity control
group sequential tests for neuroimaging
Tutorials illustrating the use of baseline information to conduct more efficient randomized trials
Covariate Adjustment in Randomized Trials
Group sequential design bounds.
896 tests / 42 scripts validating Zetyra calculators (GSD, CUPED, Bayesian, SSR incl. Single-Arm, RAR, Master Protocol). Replicates 8 published trials (Salk, DAPA-HF, PACIFIC, MONALEESA-7, I-SPY 2, STAMPEDE, REMAP-CAP, NCT03377023) + Leyrat 2024.
Derive rejection boundaries for RCTs with inconsistent covariate adjustment
📦 BayesianPlatformDesignTimeTrend: Simulate and analyse Bayesian Platform Trial with time trend
Graphical multiple comparison procedures for group sequential design clinical trials
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